bta-mir-677: Bta-mir-677 is a miRNA that has been investigated in several studies for its potential role in various biological processes. In one study, nine miRNAs, including bta-mir-677, were randomly selected for validation using RT-qPCR [PMC6876490]. Another study identified bta-mir-677 as one of the miRNAs involved in ceRNA regulatory networks [PMC7969984]. Furthermore, bta-mir-677 was found to be moderately expressed and significantly increased in macrophages infected with Mycobacterium avium subsp. paratuberculosis (MAP), suggesting its potential as a diagnostic biomarker for early MAP infection [PMC6600136]. The expression of bta-mir-677 was also found to be significantly upregulated in Brucella-positive samples compared to healthy controls [PMC7242893]. Additionally, the upregulation of bta-mir-677 was observed in response to FTA treatment and was found to target DEXH Asp-Glu-X-His box polypeptide 58 (DHX58), which is involved in pathogen recognition [PMC7943879]. In various studies, the upregulation of bta-mir-677 has been associated with the upregulation of target genes such as NR3C1 and DHX58 [PMC7242893] [PMC7943879]. The expression levels of bta-miR-205, bta-miR-708, and bta-miR-497 were also found to be correlated with that of bta-mir-677 in response to LPS+FTA treatment [PMC7943879]. Overall, these findings suggest that bta-mir-677 may play important roles in different biological processes and could serve as a potential biomarker or therapeutic target.
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