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Homo sapiens (human) long intergenic non-protein coding RNA 1787 (LINC01787) URS0000034673_9606

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LINC01787: LINC01787 is an oncogenic long non-coding RNA (lncRNA) that has been found to promote breast cancer (BC) cell proliferation, migration, and BC xenograft growth in vivo [PMC9969691]. It achieves this by repressing the maturation of miR-125b, a microRNA that is involved in regulating gene expression [PMC9969691]. Luciferase reporter assays have demonstrated that overexpression of LINC01787 increases the luciferase activities of reporters containing the 3'-UTR regions of KIAA1522, ETS1, or SNAI1 genes [PMC6848230]. These effects were found to be dependent on the binding sites of pre-miR-125b on LINC01787, as mutation of these binding sites abolished the increase in luciferase activity [PMC6848230]. Furthermore, in vivo studies have been conducted to investigate the effects of LINC01787 in breast cancer. These studies have provided evidence for its role in promoting BC growth and progression [PMC6848230]. Overall, these findings highlight the oncogenic potential of LINC01787 and its involvement in regulating gene expression and promoting breast cancer development.

Targeting miRNAs 1 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

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GAGAAUUACUCUGGAUUGUAAGCAAAUAUCUCUGGAAGAAAGGGAAAACUAAGUCAGAGCAGAAGGAGAAUUGAAAUGGUGAUGAGGACUGUGGAAGAUGAAGGCUUGGAACUGAGACCCCCUGGAAAAGACAGGCACUUGAAAGCCUAUUGCCUCAAAGAAAAGAAGGAUGUAUCCUCUAUCCAGCAAGCCUUUUUCAAUAAAAUCAUUAUGUACUCCACCUGCAACAAGGAAAGAAAACAAAGUUCCGUGAAUAACUAAAUCAUCAUAAUGAAGCAAAACGAUAAGCAGAAAGCAAGAGUGUUUUGAAAGCAUUGAUCACAAUAGCCAAGAAAUGAAGCAAUCCAGUAUCCAUCGAUAAAUGGAUGGAUAAAGAAAAUGUGGUACAUACAUACAACGGAAUAUUAUUCAGCCUUAACAAUGAAGGACAUCCGGACACAUGCUACAACAUGAAUGGACUUUGAAGACAUUAUGUUAAAAGCAAUAAGCAAAUCACAAUAGACAAAUACUAUAUGACAUAUGAUUCCACUUAUAUCAGGUACUUAGAGUAGUCACAUUCAUAAAGACAGAAAGUAGAAUGGUGGUUUCUCCGGGGAAGGGAAAGAGAGACUAGGGAGCUGUUGUUUAAUUUGUGAAAUCAAAAGAAUUUUGAAGAUUGCUUGCAUAACAUUGUGAAUAUAUGAACACUACUGAACUAUGUGCUUUAAAAUGGUUAAGUUAGUAAUGAACUAUAUGCUUAAAAAUGGUUAAGAUAGUAAAUUCUGUUAUUUUACUGAUGUUUUUUUCUCUUUCAAGUUUUAUUUUAGAAUCAAGGGGAACAUACACAGGUUUGUUACAAAAGUAUAUUGUUUGAUGCUGAGGUUUGAGGUAUGAUUGAAUCUGUCACCCCAUUAGUCAGCACAGUACUGAAUAGGUAGUUCUUCGGCCUUCACGACAGUUUUUUUAAAAGUACACAAACAAUUGUAGGUAUUUAAUUUGUUACUGUGCACAUGAAUAUACUAAACAGGAAAAGGUCACUAAGCUGUGGAUAUACACAUUGUUUACAGUUCAAUGAGAAUUGGCUUCUGUUGGCUAGCAAUAAAUGUCAAACUGUUCAACAUUGAUUAAUCAUGAAGGAAUAUUGCUUAACAAAGAAUAAAAUAUCUUUCUGAGGUUACAAGCAACAACUAGCUUUCUCUGACUUACUGAUUGACAUGAUGCAAAAUGCCUUCCCAGCCUCAGCAUCUGACUUAUAUGAUAUUCUAGUCACUUACAAAGAUGACAACUGUAUUAGUCCACUUUCAUGCUGCUGAUAAAGACAUACCUAAGACCGGCCAACUUACAAAAGAAAGAGCUUUAUUGGACUUACAGUUCCAUGUGGCUGGAGAAGCCACUCAGUGGCAGAAGGACAAGAUUUCAGGCACAUCUCACAUGGUGGAAGACGAGAGAAGAGAGCUUGUGUAGGGAAACUCCUGUUUUUAAAACCAUCAAAUCUCUUGAGACUUAUUCACUACCACGAGAGCAGCAUGGAAAAGACCUGCUCCCAUGAUUCAAUUACCUCCCACUGGGUCCCUCUCACAACACAUGGAAAUUCAAGAUGACAUUUGAGUGGGGACACAGCCAAACCAUAUCAACAACAGUCUUCCAGAUACUAGGUAAAGAAAAUCUGACCCAGUUUGUUAAGGUAUGUUUACUCCUUUAUCUUACCUUAUUGGAGGUAAGAUAAAAGAUAGGUAAGAUCUUACCUUAAGAUCAGGAAGGGUGGUUCAUAUAAUACCAGUAUGGCUUCCAAUUGGUAUACCCUUGUGGAUCUGAGGGAAGAAAUAAGAAUGUCUGCCCCAUAAGAAGCUAGGAGACAGAUUUUGGAGUCCCUGAGUCCCUGAGACCCUGACUUGGUUACAACAGCCAGAGAGAACUGUGGGAAUCCCUGAGAUGGCAGCCUCAUCUUAAAGGGUGAUUACUAGAGAUAAUAAGGGGGAGAAGCCUUGGUGAGCAUCCUGGACCAUUUUGGUUCC

Taxonomic tree

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Expression New Publications