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Homo sapiens (human) small nucleolar RNA, C/D box 37 (SNORD37) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, C/D box 37 (SNORD37) URS00000335D1_9606

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SNORD37: SNORD37 is a small nucleolar RNA (snoRNA) that has been studied in various contexts. In ob/ob mice, the expression of SNORD37 was reduced in bone marrow adipocytes [PMC3743818]. SNORD37 has been found to produce predominant 22-nt sRNAs, along with additional minor RNA products of different sizes [PMC8184798]. It has also been observed in both tumor and adjacent normal breast tissues, as well as in CLL and normal total tonsillar B-cells [PMC5951800] [PMC9219770]. SNORD37 was found to be hypomethylated in certain genes, such as Klhl1 and Slc2a13, while being hypermethylated in others like Nav1 and Palm3 [PMC7519103]. It is also associated with a microdeletion syndrome on chromosome 19p13.3 that includes PIAS4, ZBTB7A, MAPK2, and partially EEF2 [PMC5952563]. In the context of non-small cell lung cancer (NSCLC), SNORD37 was studied as a potential biomarker along with miR-223 and miR-212. However, the sensitivity and specificity of the panel including SNORD37 did not differ significantly from miR-223 alone [PMC9044851] [PMC5650736]. Furthermore, SNORD37 expression was found to be significantly decreased in sputum samples of NSCLC patients compared to controls [PMC5650736]. Overall, SNORD37 has been investigated for its potential role as a biomarker in various diseases including cancer.

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2D structure Publications