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Homo sapiens (human) hsa-miR-4758-3p URS0000031E74_9606

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hsa-mir-4758: Hsa-mir-4758 is a microRNA that is downregulated in MG and G, as shown in a study [PMC7393356]. It is highly expressed in endometrial cancer (EC) tissues and is associated with poor prognosis and lower survival rate [PMC9318842]. Hsa-mir-4758 may serve as a novel biomarker for predicting survival in EC [PMC9318842]. It participates in the post-transcriptional regulation of gene expression by affecting mRNA stability and translation [PMC9318842]. In addition to hsa-mir-4758, other miRNAs such as hsa-mir-96, hsa-miR-5094, hsa-miR-3620-5p, hsa-miR-5091, hsa-mir-663b, hsa-miR-5010-5p are also downregulated in MG and G [PMC7393356]. Furthermore, the study identified other miRNAs that are highly expressed in EC tissues and associated with poor prognosis and lower survival rate such as hsa-mir138-2, hsa-mir-548f-1, hsa-mir934, and hsa-mir940 [PMC9318842]. Survival analysis showed that five miRNAs including hsa-mir138-2, hsa-mir548f1, hasmir934 hasmir940 hasmir4758 were highly expressed in EC tissues [PMC9318842]. These 12 miRNAs including hasmir1382 hasmir548f1 hasmir934 hasmir940 hasmir4758 were identified as potential variables for a prediction model for EC prognosis [PMC9318842]. References: [PMC7393356] - Zhang H., Zhang Y., Zhao H., et al. (2020) Identification of potential biomarkers for predicting the prognosis of gastric cancer. Oncol Lett, 20(3): 1-12. [PMC9318842] - Wu Y., Zhang Y., Zhang H., et al. (2021) Identification of key miRNAs and genes in endometrial cancer by integrated bioinformatics analysis. J Ovarian Res, 14(1): 1-12.

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