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Homo sapiens (human) INKA2 antisense RNA 1 (INKA2-AS1) URS000001A4F7_9606

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INKA2-AS1: INKA2-AS1 is an important long non-coding RNA (lncRNA) that has been identified in bone marrow-derived mesenchymal stem cells (BM-MSCs) [PMC8479280]. It has been found to have intimate interactions with miR-339-5p and miR-1908-5p, which are known to regulate the osteogenic differentiation of BM-MSCs [PMC8479280]. INKA2-AS1 is also involved in autophagy and mitophagy pathways, along with other lncRNAs such as MIR99AHG, STXBP5-AS1, SMILR, LINC01503, and LOC105747689 [PMC8479280]. The expression of INKA2-AS1 has been found to be upregulated in qPCR results, along with other genes such as miR-210-5p, miR-431-5p, ITGA6-AS1, STXBP5-AS1, LOC102723409, LOC105747689, LINC01013 [PMC8479280]. It has also been reported that INKA2-AS1 negatively regulates the chondrogenic differentiation potential of stem cells [PMC8479280]. INKA2 is a novel downstream target of p53 that is potentially involved in mechanisms regulating the actin cytoskeleton and actin-driven processes [PMC8479280]. Additionally, several genes including NGEF and SULT2B1 have been found to be downregulated in relation to several cancers [PMC9534417]. Overall, INKA2-AF1 plays a crucial role in BM-MSCs and its dysregulation may have implications for osteogenic differentiation and chondrogenic potential.

Targeting miRNAs 1 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

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GAAGAGGACCCUGGGAAGGUGGCUCCCGCCUCACUCCUAGAGUGAAAUCCUCGCAGCCCUGCCCUCGCGGGCGGAGCAGAGACGCCGCCGCUUGGCCGGUUCACGCCUGUCACACAAAGCCGCCGAGGGUCGGCUGCGCCCCUGGCAAGGCUGUAGGGCUGGGGAUACUGAGUAUGACAGGCGAGGUCCCUGCUCUCAAGAACUUACAUGGGAGAGAAGGGGAGACAAGAUAAACAGAUGGAGCAACUCAACCCAAAAAGGUUGGUCUGUAUGGUGACGGAAUGUGGUCUCCCAGUUUUCAGCACAGCACUCAUUCAGCUAUUCUGCUCUUCAGAAAGCAGGAGGGAUGUGCCCUAAGGUGGACUAUUGAAAUGAUGAAAGCCACUGAGGAAGAGCCAGAGAAUUCUCGUAGCUGUGAUUAGACAUCAACCUUGGGCAUGCUAAACAUUUCAGCCUGGACACCCUGAGAAGAGCCAGUGCCACUGGUGACAGCUGCUUCUGUGCGGGCUUUUGCUUGGCCAGAGAGGCAGGACCUUCUCCCUGGCAUUUUGAGGAGUGGUGCCGGGUGGGCAGUGACUGCACUAGCAACAGUCUAUACCAAGAGAAGACCUCAAAUUCCCAGAGAAGAAAGGCAGCGAGGCCAAGAAAUGCUGCCGCCGCUUAACAAGUGAAGAUGCAUACUGGAGAAUAGGAACUGAACACGCGAAGGAGUUUCGGCUUUACUGCCUUCUCUCCUAGCAUUGAACAGAUCUUCUCUGCUGUUGAUUAUUCUCCAUGAAUCAUCAUCCAUAGAAAGUGACUGAGGCAAUAGAGAGUGAAUAAUGAAUCUCUCAAAUAGUCUUUUGUGUUUCUGCCUGGAGGGUUUUGGAAAUAACUUGCAUCUUAAUCUUUCUGACUUAGAAUCAUAGAAUUUGGGAGCUGAAAAGGACCUUCAUCAGGGCAUGUGGCCUCACAGAAAGACUGGAAGAAAAGAUUUGUGGGUAUGAGCCUCUGGUUCAUCACUAAAAAUAGGCCUAGUCUAACAUAUAUUGGAGGCUUUCCUUGUGUCAGGUACUCAUUUAUUCUUCCAAAACCUUGGGAGGUAGGUGCUGCUAUUCCUCCAUUCUGCAGAGGAGGAAGAGAUGAGGAGACAGUAGAUCACCAGAGGGCAGUGUGAGGGGUGUGCUGGAACCAUCAUGUGGAACUGGCUCUGGUUCCAGAAUCCACAUCCUCUCGGUCAUUCCACUCCCACAUCAAGUGGCUUUGGACAAGUAAUUUAACUUCUUUGGAUCUCAGUUUUCUCCUCCGUGAUCUCUAAAGUUUAAAAAUUACUAACAGUCUGCAUCUGCCACCCAAGCAUGUGAUUUUACAAGUCAGAAAAGUGUAGCGCAGAAAUGUUAAGUGACCUGCCCUAGGUCACCCAGGUUGCUAAGGGCAGAAUCAGCACAGAAACCCAGGCCCAGUGACCACUGCCCCCAGGCAAGACCUCCUUCCCUUCCACUGCACUUUGGCAGGUGUUCUAGGGGAAUCCAACUCCUUGCCUUAGAGGAGACCUGUUCAAUGAUAUCAGAUAGACUGGAGAUGUUACGUUUUGGUGUGGCCAAUCACAACACCAGGAUGAGCUUAGGAGGCUGGUGAUAUUUGUCUAUCUAAGCACCCCCAACCUAUCUAUCUGUCUGCUGUUUGUCUAUCUUUCUCAGGUUAUGCAUAGUGACCAAACCCCGCCUGGUAACUGUAGGGAAAGAGCAUGACUGGUGUGUUACAGCUACACACGCCCCCUGGUGGUAUUUCCAGUUGUUUGUCCUCUUCAUGCAAAUGUUGCCACCUUGUGCCAGCUCUCUCACCUAGCUUCCUUCAUGACGACAGUGGUUGCAAUUCUGCUCCUCUCUCUGCCUUCCCCUGUCCUUGGCUCCCCAUGUCCAGAAUCUGAUCAUUUACUGGUGUGCACCCUGGGAUGUGAUGUGUGCUUUGGGAGGAGACAGGACCCAACAGUAUCUCAGCUGUGCUCUGGUAAUCAGUGUGCACCACAUUACAAGCAUCCUCAUCCCAGUAUCCUCCCUAUUGAAAAAGAAAUGGGAAAGGGGUGGAUGUGUCAAUAAACACAACAUUGAAGGCAUCUGAAAUAGAACAAGGACAUCCUGGGUGAGGCAUU

Taxonomic tree

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Publications