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Homo sapiens (human) small nucleolar RNA, H/ACA box 46 (SNORA46) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 46 (SNORA46) URS0000018549_9606

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SNORA46: SNORA46 is a small nucleolar RNA (snoRNA) that is identified in bovine and human species [PMC7072903]. SNORA46 has been found to be highly expressed in grade I tumors compared to grade II/III tumors in meningioma [PMC8797451]. Its expression decreases from the beginning to the late stage of endometrial secretion [PMC8221328]. SNORA46, along with SNORA48, has been identified as a downregulated candidate gene linked to meningioma progression [PMC6489307]. It is expressed at significantly higher levels in grade I meningiomas compared to grades II and III [PMC6489307]. The higher levels of SNORA46 found in low-grade meningiomas suggest its role as a tumor progression suppressor [PMC6489307]. Additionally, SNORA46 has been found to be downregulated in chondrocytes and differentially expressed between grade I and grade II/III meningiomas [PMC7461137] [PMC6510770] [PMC7484374]. It is predicted to guide the modification of uridine (U469) in ribosomal 18S rRNA and has been associated with systemic sclerosis in patients with auto-antibodies to SNORD15 [PMC7212295].

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Gene Ontology annotations


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2D structure Publications