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Homo sapiens (human) ITGA6 antisense RNA 1 (ITGA6-AS1) URS00000137A7_9606

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ITGA6-AS1: ITGA6-AS1 is a long non-coding RNA (lncRNA) that has been studied in the context of MSCs (mesenchymal stem cells) and its potential association with ITGA6 expression. ITGA6-AS1 is significantly higher in MSCs from bone marrow (BM), cord blood (CB), and placenta (PC) compared to other sources [PMC9535380]. It has been found to overlap with the ITGA6 exon 2 sequence and may be involved in the regulation of ITGA6 [PMC9535380]. The expression of ITGA6-AS1 is inversely correlated with that of ITGA6, suggesting its potential role in regulating ITGA6 expression [PMC9535380]. The sequence features of ITGA6-AS1, including its partial complementarity with the ITGA6 transcript, suggest a potential post-transcriptional influence on the stability of ITGA6 mRNA [PMC9535380]. Additionally, bioinformatic analysis has identified potential microRNA binding sites within the lncRNA sequence [PMC9535380]. Further studies are needed to explore the regulatory role of ITGA6-AS1 on MSC function and fate, as well as its interaction with other lncRNAs and mRNA transcripts [PMC9535380]. It is also suggested that overexpression or inhibition analysis of ITGA6-AS1 could provide insights into its effect on regulating ITGA6 expression [PMC9535380].

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Gene Ontology annotations


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