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Homo sapiens (human) small nucleolar RNA, H/ACA box 4 (SNORA4) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 4 (SNORA4) URS000000AB5A_9606

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SNORA4: SNORA4 is a small nucleolar RNA (snoRNA) that has been found to be decreased in the learning group [PMC7164515]. It has been observed that snoRNAs, including SNORA4, can undergo adenylation, resulting in the addition of adenine residues [PMC8583065]. This adenylation has been detected in various snoRNAs, including SNORA4 and SNORD86 [PMC8583065]. In Xenopus, SNORA4 has been identified to have antisense elements that position a conserved pseudouridine in 28S rRNA [PMC6984369]. In the context of influenza A infection, it has been found that SNORA4 is significantly down-regulated in response to seasonal H1N1 infection but not pdmH1N1 infection [PMC2988725]. This suggests that seasonal H1N1 virus may be more efficient at suppressing host translational mechanisms and allowing for efficient translation of viral mRNA [PMC2988725]. Additionally, it has been noted that EIF3A contains a single copy of SNORA19 and EIF4A2 introns contain several snoRNAs including SNORA4 and SNORD2 [PMC8759569].

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2D structure Publications