Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.
Homo sapiens (human) RNA, Ro60-associated Y4 (RNY4) secondary structure diagram

Homo sapiens (human) RNA, Ro60-associated Y4 (RNY4) URS0000007D24_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

RNY4: RNY4 is a type of Y RNA that has been identified as a potential biomarker for anaplastic large cell lymphoma (ALCL) liquid biopsy [PMC8534237]. In a study, it was found that a partially modified LNA RNY4 oligonucleotide was as effective as a fully modified LNA RNY4 oligonucleotide, demonstrating a reduction in RNY4 fold change [PMC9996952]. Additionally, the partially modified LNA RNY4 oligonucleotide outperformed fully modified 2’OME RNY4 oligonucleotides [PMC9996952]. Among the Y RNA transcripts, RNY4 was found to be the most abundant and was not significantly induced with TNF-α stimulation [PMC6086399]. To gain further insight into the function of Y RNAs as ligands for the RIG-I receptor, researchers developed a secondary structure model of RNY4 and assessed the probability of different sets of sequences from viral or human origins to fold along this model [PMC9250025]. These findings suggest that exosome-encapsulated RNY4 could be utilized as an innovative biomarker for ALCL liquid biopsy and highlight the potential therapeutic applications of modified LNA or 2’OME oligonucleotides targeting RNY4 in ALCL treatment.

Genome locations

Gene Ontology annotations


Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

This sequence is found in 27 other species

  1. Ailuropoda melanoleuca Y RNA (ENSAMEG00000030474.1)
  2. Callithrix jacchus Y RNA (ENSCJAG00000082905.1)
  3. Cebus imitator Y RNA (ENSCCAG00000000313.1)
  4. Cercocebus atys (Sooty mangabey) Y RNA (ENSCATG00000007100.1)
  5. Chlorocebus sabaeus (African green monkey) Y RNA (ENSCSAG00000025277.1)
  6. Colobus angolensis palliatus (Angola colobus) Y RNA (ENSCANG00000016938.1)
  7. Dasypus novemcinctus (nine-banded armadillo) Y RNA (ENSDNOG00000028615.1)
  8. Equus asinus asinus Y RNA (ENSEASG00005009022.1)
  9. Equus asinus Y RNA (ENSEASG00005009022.2)
  10. Equus caballus Y RNA (ENSECAG00000025921.2)
  11. Fukomys damarensis Y RNA (ENSFDAG00000003734.1)
  12. Gorilla gorilla gorilla Y RNA (ENSGGOG00000035071.2)
  13. Macaca fascicularis (Crab-eating macaque) Y RNA (ENSMFAG00000034878.2)
  14. Macaca mulatta Y RNA (ENSMMUG00000028452.3, ENSMMUG00000059522.1)
  15. Macaca nemestrina Y RNA (ENSMNEG00000024804.1)
  16. Mustela putorius furo Y RNA (ENSMPUG00000021160.1)
  17. Neogale vison Y RNA (ENSNVIG00000003927.1)
  18. Oryctolagus cuniculus Y RNA (ENSOCUG00000018615.1)
  19. Pan paniscus Y RNA (ENSPPAG00000016316.1)
  20. Pan troglodytes Y RNA (ENSPTRG00000038023.2, ENSPTRG00000049197.1)
  21. Papio anubis Y RNA (ENSPANG00000017873.3)
  22. Piliocolobus tephrosceles Y RNA (ENSPTEG00000030638.1)
  23. Rhinopithecus bieti (Black snub-nosed monkey) Y RNA (ENSRBIG00000024485.1)
  24. Theropithecus gelada Y RNA (ENSTGEG00000002319.1)
  25. Ursus americanus Y RNA (ENSUAMG00000015060.1)
  26. Ursus maritimus Y RNA (ENSUMAG00000011458.1)
  27. Ursus thibetanus thibetanus Y RNA (ENSUTTG00000008294.1)
  28. Zalophus californianus (california sea lion) Y RNA (ENSZCAG00015016009.1)
2D structure Publications