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Homo sapiens (human) prostate cancer associated transcript 5 (PCAT5) URS0000003826_9606

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PCAT5: PCAT5 is a long noncoding RNA (lncRNA) that has been identified as playing important roles in regulating tumor progression and is dysregulated in various types of cancers, including prostate cancer, breast cancer, and kidney cancer [PMC7557915]. Knock-down of PCAT5 expression in ERG-positive DuCaP cells has been shown to significantly reduce cell growth [PMC7900491]. PCAT5 expression has been strongly correlated with ERG expression in ERG-positive primary tumors and castration-resistant prostate cancers (CRPCs) [PMC7900491]. It has also been confirmed that the expression of PCAT5 is significantly decreased as a result of siRNA-mediated knock-down of ERG [PMC7900491]. PCAT5 is one of the lncRNAs associated with castration-resistant prostate cancer (CRPC) and is regulated by the transcription factor ERG, which is activated in 50% of all prostate cancers [PMC5344005]. Knockdown of PCAT5 leads to enhanced apoptosis, reduced proliferation, and reduced invasion in PC-3 cell lines [PMC5344005]. Additionally, PCAT5 is particularly overexpressed in ERG-positive metastatic castration-resistant prostate cancer (mCRPC) compared to healthy prostate tissue and could serve as a therapeutic target for this subtype of prostate cancer [PMC5344005]. Furthermore, studies have identified associations between variants near the intergenic region between PCAT5 and ANKRD30A with smoking initiation and smoking-associated genes [PMC7509597].

Genome locations

Gene Ontology annotations

Sequence

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CUCCUGAGGCUGCAGCAAGAUCAGGGAAGCAAACCUUUGCAAAUGAGACAUGUACCGUGUAAAAUGGAAAUGCUUUCCUUGGCAGUGAGUUAAGCAUUUUCACGAUAACAAUUUGGAAUCCUAGAAAAAUAACUGGAUUUUGAAAUGGAAAAUGAGCUCUGCACUUUGCUACUUUUGUGACCCCACAUCCUCAUCUCCAAAUGCGGAUGUUACAACAGAGCUUGCUGCGGAAGUAAAAUUUCAAAAUAAUCCUCCAACGUGUUUGUGGCCUGAAGGAGCAGAGCAGCGGUGGGAACAAUUUAAUUCCUAAUAAAGUCCAUACCUCUAAGUCGCUGCGUGUGUGCCAUUGAAACGCAGAGAAGUUGCUAGAACUCCUCCACUCCUGCAGAGCUGUUGCCUCUCUGGGCCUGUGUGACAAUGUUUGCUCUCCCUGCUGUCACUUUGCACUUCCCCGAGUCUCUCUGGAUGGCACUUCAUGAUUUCUCCCUGAAGCAAUGAUGGAAGUAUGUCAGCUGUCAAAGGUUCUGGCAGCAGAAGGCAGCUGAGAAUAAAGCGGCUUCACGGUAAUGUCGGUGACCCCCUAACCAUACCCCGCUUUCCACCGAUGAUUUGUCUGGACAGUGUUUAAAGCAGAUGAAAUAUACAUUUUUUGAAUCAGGCAACAGGAGAUGACCAGUGCUGGGUUUCAUGGGAACCAGAGGAUUUACAACUUUGCUUGGGCUCCACGUACCAGCAGGAGCCUGAUGAGGAGGGCGGCUGUGUUCUGAAUUGUUUUAGGAAGUCUCCUUCAGCCCAAGACCGUCUGGACAAAAUUGCCAUGGGAUCCUGUUGCUGCAGCAGGAUGUUACCAAGUGAGACGUUGACUCAAAGAAGGGGAGCUGAGAUCAGGAAGGCCAAGAUGGCAUCCAAAAAUUCAAACACACCAAGGAGGCCAGGUGCGAUGGCUCACGCCUGUAAUCCUAGCACUUUGGAAGACCCAGGUGGGUGGAUCACCUGAGGUUAGGAGUUUGAGACCAGCCUGGCCAACAUGGUGAAACCCCAUCUCUACUUAAAAAAAAAAAAAAUCAGCUGGGCGUGCUAGAAGGCACCUGUAAUCCCAGCUACUUGGAAGUCUGAGGCAGGAGAAUUGUUUGAACCCGGGAGGUUGAGGUUGCAGUGAGCCACGCCACUGCACUCUAGCCUGGGCAACAAGAGUGAAAUUCAGUCUCAAAAAAAAAAAAAAAAAAAAAAAAACCAAAAAACAAAACCUCCAAAGGACAUAUGUGUGCUCUUGCUCUCAGGAAGCUUGUGAUUCCUGGGGAGAAACUGAUCACACACACACCGAGUAUUGUAAAGUGAUUCAAAGUUGCACAAGGGAGAGGCAAGUUCUGAGUCUCCUCCUGCCUCCCAGUUCCCUUCCUUGAAUGCAGGGUCACUGACUGAUUGGUCACAUCCCAAGACCAUGAUUGGCUAUUUUACAAGUAGACAAGGUCACCAUGCUUUAACAGGCAAGGCCCCAUGAGCCACCUCUCUUUGUUGGAAGUUGCCUGCGUCUGGCCCUCCUCUCACUUCUUGAGUGUAGGUUUGAGGUCUGGGAAUGCUGCUGGUAGCUGUGGUCCAUCCCUUUCAAGAUUGGGAUUUGGAAGAUAAAGGAAAGAUCCUGUUUGGAGCCUGAGCCUAAGCAUAGAGUUCCAGCCUGAGGUUGCAGAGAGGCCCAGCCUUGGGUGUGGGUUCCAAGCCCAGAUGGCAAUAAAGGAGCACCCUGUCUUCCUACGGGCUGGAGUUCCUUUUGAGAGUGCUUCCUGGGAAAUGUUGUCAUAACAUUGACAGGGCAGAAUUUCAGCAUUUCUCACCCUUGGCCCUAAUAUCCAUCUCCCAAAUCACCCCCAGUGCCAGGAAUCAUUAAGAAAGCAGUGGUAGUGUUGAGACAACCAAAAGGCUGUUAGUUUGAGAACCGUCACAUAUAGCAGAUGGAAUUCUUGAAAAAGUGUCUUCAGCAUUAGGUAGAGGCAUAUUGUUAUACAUAAAGAAAGGCCGGAGAAAAACACCAAGAACUUUCUGGGGUAACUUCUCUACAGGAGGUUGCUGUGUCCCCCUAGACAGCUCUAUCAACAGGUGAGGACUGGGAAUCUAGUGGUGAAUUGAUGUGACUGGGUUGGGGCAGAAAUGCCAUGGGGCCUGAUGCAGCACAGCUGUACGUCAUGGAAAAUGAUCCCUGAGACAGUCAGCAACUGGAUGUAGAAUGAAUCUGUUUAAGUAAUGAGUGUUCGCUUUAGGAGAGCAGGAUGCAGGACAAUAGCCAGGAGAGAGCAAAACCUGUUUGAAAGAGUUGAGGGAUUUGUGAUGUCCUGCCUGACACACCAGCACCCCUGAUGAUGCUGUCAAUGGCUUUCUCUCAAUUAGUCCCCCUGGACAGGUGGAAGCCGAGGUAAGUUGGGUAAUUGAUGUCUUCAUGCUUCCACAAAGGGCCUACUUUGGGAAGAUGGAAUAUGUUAAUGCAGGUCCCUGCAUGAAGCAGGGAAUUCUGAACACAUUUGCAGGCCGGUGAAGGAAAGGUCCUUCCCCAUGUCAUGGUUCCACAUGCUCUCCACCAUAAACUUGGAAGAAUUCAAGCUGACACAUCAUGUGAAAUUCAGGGUGAAAAAAGUCUGUUGAAAUGGAUAAUGGAAUGUGGAAGACCUGUGGAACAUGUAGUUGGACCUUUAACUCUGUCUGUAUCCACACAAAAGCCUGUAAUAGAAUGUUCAAGCAUAACAUCCUUGAAUUUUUCAAAAAUAACUUUACAGCUGAUCCAUUUAUUUUGUCGGUGGGGUGAGGGGACAGAGAGAAGAAUGGGAAAGAGAGUGAGAGCAGGGAAAGAGAAGAGUGAUGAUUGAAGGGGAAGAGAAGGAAUUUUCUAACAACUCCUUGCCACAAAAUGAUGAGUGAUGGUGAGUGAUUUAAUUAGGUCAUUAAGUGGAUGAAAUAACAUGGCCAAGGUAAACUUACGUAAACUGUUUCUUAUUUAAAUUAUAUUGGAUACUUGGAUCAUCUGUUUAAUAAAAAAUCUCAUCCACUCUUCAAUAUUGGCUUAAAUCCUCUCCCCUGAACAAAACCUUUUCUAAGCACUGCAACUGGGACAUUUUUUAGUUCUUUUUACAUUUUUUUUCCAUAUUAUUUAGUUGAAACUAAUUGCAUGGAGCUCUAUUCCACGUAGUUACUUCCAUGGGUCCAUGAGUCUUAUUUCUCCCCAAAGACAUUUUUCUUAGGGAGGAAGAAACCAAGCUACAAACGUUUUUCUCAUGUGCUUCCUACACUGUGUUCUGUGCAGUAGAUGCUGCUGAACAUUUGCCAGGAGCCUGAUAUUUGGAAAGUUUGGCUCAUUUUCAAGGCUAUGCAAUUUAAUGAUACUGACAAACCCCAAAAUUUCUAGAUCCCAAUUAAGUACUUCAUUGUCCUGACUUCAUUCAUCAUAAUGGAAAAUUAACUUACUGUCUAAUAUCUCAUUUUCUUCUCUUUAAUAUAGAUAAUAAUAAACUAACCCAUGCAAAUGUAUUGAAGAAUAAUGAAUAAAUAAAAUUUACAAGCAAAU

Taxonomic tree

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Publications