v24

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Homo sapiens (human) DLGAP1 antisense RNA 2 (DLGAP1-AS2) URS000075EE3F_9606

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DLGAP1-AS2: DLGAP1-AS2 is a long non-coding RNA (lncRNA) that has been found to regulate the expression of key components in the Wnt/β-catenin signaling pathway during gastric cancer (GC) progression [PMC8831387]. However, its role in modulating the radiosensitivity of cancer cells and its involvement in rectal cancer is still unclear [PMC8844799]. In a study comparing low-risk and high-risk groups of patients, it was found that the low-risk group expressed higher levels of DLGAP1-AS2 [PMC6865675]. DLGAP1-AS2 was also shown to affect cell proliferation in H2170 cells [PMC8401159]. Furthermore, DLGAP1-AS2 was found to regulate the binding of E2F1 at the CD151 promoter [PMC8844799]. Mutant forms of DLGAP1-AS2 were constructed to identify regions responsible for binding to CPSF2, CSTF3, or ELOA [PMC9664729]. The association between DLGAP1-AS2 and clinicopathological features was analyzed using the Pearson chi-squared test [PMC8452735]. In colorectal cancer cells, DLGAP1-AS2 was found to promote proteasome-dependent degradation of ELOA [PMC9664729]. The co-expressed genes of DLGAP1-AS2 were analyzed using TCGA dataset and functional enrichment analysis was performed using GO and KEGG analysis tools on DAVID website tool [PMC8452735]. Overall, there is still limited knowledge about the molecular mechanisms of DLGAP1-AS2 in cancers [PMC9664729].

Genome locations

Gene Ontology annotations

Sequence

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GUCUUUCAGGAUGAAUGCCAUCCACACAAAAGAGCUCCUGUUGACAUCUCAUUUACAAUCUCCCCCAGGACACAGACAAGACCCUUUCAAUAAAUCCAGCUCAGAAACACCUAUUGUUCAAAAUCUUCAACUCGCCACAGGCUACCACCACUCCCUAUGGCUUUGCAAAAUUAAAGAUUUAGAAGAAGGAUGGGGCGGUGGAAGCUAUGAAAAGAGGCAGGAAAAAAGUUCCUUUGACCCGAUGCUGUCAGAGAGCGUGCAUGAAGAAGAAAGUUAAUGGUAUUUCCAUUUAUAUAAGAAGCGCCUAAGAAAUGCCUGUGACGUUCGUGAACUAGUGAUUGUGAAUUCCAAAUUUGAUGCCAACUUUAUGUGUAAAGAAGCUAACUCCUGCCAACAUCGUGGCUGAAUGAACAGCUGGGACUAUGCUUAACCCAUUCCCAGCUUAUAAAAGCCCCAUGGCAGCUGCAGUGAAGCAUCAGAAAAGUAUAGUAAGAAGAAACUGAAUUUGAAGUGGAUUCUUACAAAGGAAAAAGAAAAUCACUAUUGUAACUAUACCAAAUUACUAUAUUAUGUGAUGCAACAAAAUUCAAAUAUGAAAACCAUCUCGGAGGCCGGGCGCGGUGGCUCACGCCUUUAAUCCCAGCACUUUGGGAGGCCGAGGUGGGUGGAUCAUUUGAGGUCAGAAGUUCAAGACCAGCCUGGCCAACACGGUGAAACCCUGUCUCUACUAAAAAUACAAAAAUUAACUGGGCGUGGUGGCACAUGCCUGUAAUCCCAGCUACUCGGGAGGCUGAGGCAGGAGAAUUGCUUGAACCUGGGAGGCGGAGGUUGCAGUGAGCCGAGAUCACGCCAUUGUUCUCCAGCCUGGGCAACAAGAGCAAAACUCUGUCUCAAAAAUAAAAUAAAAAAUUGCUUUAAAAAAU

Taxonomic tree

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Publications