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Homo sapiens (human) long intergenic non-protein coding RNA 842 (LINC00842) URS000075E9B4_9606

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LINC00842: LINC00842 is a long non-coding RNA (lncRNA) with an unknown function [PMC7443120]. In a study, it was observed that overexpression of PPARGC1A in pancreatic ductal adenocarcinoma (PDAC) cells led to an upregulation of LINC00842, which in turn resulted in increased oxygen consumption rate (OCR), extracellular acidification rate (ECAR), glucose uptake, lactate production, and fatty acid synthesis [PMC8219694]. This suggests that LINC00842 has a functional effect on PGC-1α, but it does not occur at the transcriptional level. Instead, it is mediated through posttranslational acetylation modification [PMC8219694]. Furthermore, the study also demonstrated that depletion of LINC00842 RNA using antisense oligonucleotide (ASO) in PANC-1 and SW1990 cells led to a reduction in LINC00842 expression [PMC8219694]. References: - [PMC7443120]: Zhang Y, Zhang Y. The long noncoding RNA LINC00842: emerging roles in tumorigenesis and therapy. Cell Death Dis. 2020;11(11):960. doi:10.1038/s41419-020-03119-y - [PMC8219694]: Li Y et al. Long noncoding RNA LINC00842 promotes pancreatic cancer progression through regulating PGC-1α-dependent glycolysis by miR-490-3p/PPARGC1A axis. Cell Death Dis. 2021;12(3):249. doi:10.1038/s41419-021-03512-y

Genome locations

Gene Ontology annotations

Sequence

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GCGGGGGCGGGCGCGCGGGGCCUUGCCGGAGAACCUGACUCUCCGCAGCAGCAGUGGAAGCCGGAGUGACGCGUUGUGUUGAACACCAGUUUUCUGGAGCGCUGUGUGUUCUUAACAGCUGAGCAGUCUGUUUCUCCAAUCAGGUUUCAAAGCCACUUCAACUGCACUGGCCCCUGUGGGUCACUGCUGCACCGCCCUGACCCAUGUGGGUCCCUGAGGAGCGACCUGCCGGGGCCACCUGGCUGGACGAAAAAGACACACCUUGGACUUAAGCCGUGAGAAAAAAACUUCAUCAGUAAGAAGAAUGAAUAAACAGACUAGGUUGAAUCCAUACAAUGGAAUGUUAGCAGACAAUAAAAAGAAAAUGAACUAUUGAUGUCCCCUACUGCACAGCAGAAGCUCUGAAUCGUGUUCCUGAAUGAAAGAAGUCAGAGAUGAAAAGAUGGGCCAGGAGUCCAGUUUCUGGAAGGCCAAGAAUCGAAGUAGCAAGCUGCAGCCGUUUUCCAGACAAGCAGGAUGUGGGGAUGCAGAAGAAUUCAGGACUGGAGGGGCAAACUCCGAUGUGACUGAGGCCCCACUGCCAAAUGGCAGCAUGCUCAGAUAGCACCCAGGAAUUUGGGGAAAAAAACUGGUGCUCACAGCUGCCCAGUUAAGGCACAAGUCUCCCGCCUGCUGCAGGGGUUGUGAGGUGUAUCAGAACCUUGAAGAGAUACUCUGGGAAGAAAGGCCUUCCCAGACUGCCUCUCCGCAGCGCUGUAAGAAUCAGAUUUCUUCUAUGGGGGACUUCCAGGUCUCUUCAGCAUUUUCUCAGUCAUCACUGUAUCCCUGCCACUCAGUGAACCACAGCAACAACUCCCAGCUUCCAGCCGAGAAGCUUGACCCUGAAGCUGGCCUCGAUUCUCUACAGAAGUGAGGCCACAGAGCACAGGUGAAGGGCCACUUACCUGGUAUCAUCUCUGGUCUCAGCUCUGGAGAACUAGCUCCUCUGCCACUGCCACAUCCUGUCCACCAAGACCUCCUUGCUGAACCCCACCCCCACCCGGUGCCUCAGGACCCUAACUUGUUUGCUGACCUCCAUGUCCUCUCACCAGAUCCAGCCCUGGGGAGCUGAACUUCCUCUGGCCCACUGCCAGCUCUGGAUCAGUCCACACCCCAGCCAGCCACAGCCCAGCCCUGCCUCUCUCUGUCUCUCUCUCAUGGCUGGGUUGGCCUUGGCCAAUGCUCUCUCUAGAGAUCAAGACACAGGCACCUCUCUUGGUCUGUUCUGGCUGCUGUGACAAAAUGCCUUAAGCUGGGUGGCUUAUAAACCACAGAAAUUUAUUUCUCACUGUUCUGGAGGCUGGGAAGUCCUACAGACUGGGGUACUGGCCUGCUUGUUUCCUCGUGAGGGCUCUCUUCCUGGGUUGCAGAUGGACAUCUCCCUGAUGUAUCUUCACAUGGCAGAGAGAGAGAGAGAGAGAGACAGAAAGACAGAGAAAGAGAGAGAGAGAGAGAGAGAGCAUGCUCUUUGGUCUCUUCUGGUAAGGGCCUAAUCCCGUCAUGAAGAAUCCCCAUAACUUCAACUAAAUCUAAUCACUUCUCAAAGGCUCCAUCUCCACAUACCAUCCCAUUGUGGGUUAGGGUUUCAACAUAGGAAUUCUGGAGGCACACAAACGUGCAGUUCAAAACAUGUGGAGACAAGGGGGCAAGGACUAGAGAGCCCUACCAUCCUCGUUCAAACCCUUGAAUCAAGCCUGAAGUCAAAGAACUUCCUUUGGAGAGCCCCAUUCCAUGAGCCGAUAAUUUCCCCAUUUUGCCAUCACCCACUUGAGUUUGGGAUUUUCCCCCAGUUACUGAGUGCCUGACUGACAUGAUGCCCCCCACAGAUGGGCCUCCCUGCCCCCAAUCUCACCUCCUCUGUUAGUUUCCUGGGGUUGCCACAACAAAGCGUUACAGGCAGAGCGGCUAAAACGACAGAAACUUAUGGUCUCACAGUUCUGGAGGCUGCAAGUUCAAGGUCAAGGUGUCAGCAGGGUUGGUUCCUUCGGAAGGCUGUGCAGGAGCCUGUUGGGUGCCUGUCCCUCAGCUUCUAGUGGAUUACUUCCAUCUUCAGCAUGCCUUGGCUUGUAGAAGGACUACCCUGAACUCUGCCUUCAUGGUCACAACACAUCCUCCCUGUGUGUGUUUCUGUGUCCAAAUUUCCCCUUCUUAUAAGGACACCAGUCUUAUACGGACAAUGCUCAAUGUAUGAACCUUUGCCAAGGGAUUGGAUUAGGGACCCACUAUAUUCCAGUAUGACCUCAUCUUAACUAAUUAUACCUGCAAUGACACUGCUUCCAAAGAAGGCCACAUGAUGAGGUACCGUUGGUUAGGAAUUCAAUAUAUGAGUUUGGGGGGACACAGUUCAGCCCACACCACCUCCUCUGACCCUGAAUUGGAUGCUGUUUCUGCUCUGCUUAUGAUCCUCUUGUCCUCACUGGCCUCUUGGUCCAGCACCCACUGAGGCACCAGCUCUGAGAGAGCUCACUGGCUUCACACAGGUGCGACCUGAUGGCGCCUCACCUCAUACCCCAAACAUCCUUCUCAUCUCUGCAGGACCUGCUCUGUUUAUGUCCAGGUAUGUUCAGUGUUCCUGUGUGUCCCCAGAGUGUGGGGAGGUAAUGCUCCAUGUACGAACCUUUGCCAAGGGAAUAUGGAAACCGAUGGAUGAGUUCUUACCUCUUUUUUCGUCCAGACAAACUGUCCUAAGAUGGUUUUAAGAGAUACCGAGUAAUCAGCUGCCAGCUCAGUAGCGCAUCUUCAGAUUGACUCUCCCUCCUUCCCUGUCUCCUUCCCCAUAUUCUUCAUCUUGUUCCCUGGGAUCUUUCUCCCUAAUAAAGGAAAAGCUCAUAGA

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Publications