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SNORD14E: SNORD14E is a small nucleolar RNA (snoRNA) involved in RNA processing and is associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease [PMC4822961]. It has been identified as a TSS-Seq peak in mouse samples, indicating its exact 5'-end [PMC6020437]. While some researchers interpreted this peak as evidence of a novel long non-coding RNA (lncRNA), others recognized it as SNORD14E [PMC6020437]. SNORD14E has been found to be under-expressed in various brain regions [PMC4822961]. It is one of the non-coding RNAs that show upregulation following memory acquisition and retrieval [PMC4460846]. Additionally, SNORD14E has been identified as one of the top upregulated genes in certain contexts, such as primary AML1-ETO+ samples with high leukemia stem cell (LSC) content [PMC8629011]. In some studies, SNORD14E was found to be differentially expressed and overexpressed in specific cell populations [PMC3962421] and brain regions such as BA9 [PMC8280514]. Overall, these findings highlight the potential role of SNORD14E in various biological processes and its association with neurodegenerative disorders.
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