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MIR3960: MIR3960 is a microRNA that has been shown to play a role in various biological processes, including autophagy, inflammation, and angiogenesis [PMC10024539]. It has been found to be regulated by the long non-coding RNA TGFB2-OT1 [PMC8553468]. TGFB2-OT1 can bind to MIR3960 and other miRNAs, such as MIR4488 and MIR4459, to upregulate the expression of their target genes [PMC10024539]. These target genes include ceramide synthase 1 (CERS1), N-acetyltransferase 8-like (NAT8L), and La ribonucleoprotein domain family member 1 (LARP1), which are involved in autophagy and mitochondrial function [PMC10024539]. Additionally, TGFB2-OT1 can sponge MIR3960 to regulate NAT8L, LARP1, and CERS1, leading to the production of IL-6, IL-8, and IL-1β [PMC8553468].
In the context of tumor angiogenesis in hepatocellular carcinoma (HCC), it is suggested that TGFB2-OT1 may function similarly by interacting with MIR3960 [PMC10024539]. Furthermore, in the acute setting of cardiotoxin-induced injury, it has been observed that MIR3960 is present in extracellular vesicles derived from human amniotic fluid stem cells (hAFSC-EVs) that promote muscle regeneration and increased vessel density [PMC8775841].
In preeclampsia women with kidney injury or hypertension-related conditions such as glomerular injury or oxidative stress-induced inflammation processes have shown increased levels of miRNAs including miR4488 along with other miRNAs such as miR18b or miR92. However decreased levels of miRNAs such as miR30b or miR95 have been observed in preeclampsia women [PMC5933288].
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