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Homo sapiens (human) beta globin locus transcript 3 (BGLT3) URS000075A80B_9606

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BGLT3: BGLT3 is a long non-coding RNA (lncRNA) that is involved in the regulation of gene expression in human erythroid cells [PMC8295333]. In adult stage erythroid cells, BGLT3, along with HBBP1, HBE, and HBG1/2 genes, is sequestered away from the active transcriptional hub at the β-globin locus [PMC8295333]. This sequestration suggests that BGLT3 plays a role in the regulation of gene expression during different developmental stages [PMC8295333]. Furthermore, BGLT3 has been found to be involved in the induction of fetal hemoglobin (HbF) by various small molecules [PMC9837035]. This suggests that BGLT3 plays a key role in the regulation of HbF production [PMC9837035]. The conformational change observed between fetal and adult stage erythroid cells at the β-globin locus highlights the importance of BGLT3 in this process [PMC8295333]. Understanding the role of BGLT3 and its interaction with other genes at the β-globin locus could provide insights into potential therapeutic strategies for conditions involving abnormal hemoglobin production [PMC8295333].

Genome locations

Gene Ontology annotations

Sequence

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UUAGCAGUAACUGCUGAAUUCCUGGUUGGCUGAUGGAAAGAUGGGGCAGCUGUUCACUGGUACGCAGGGUUUUAGAUGUAUGUACCUAAGGAUAUGAGGUAUGGCAAUGAACAGAAAUUCUUUUGGGAAUGAGUUUUAGGGCCAUUAAAGGACAUGACCUGAAGUUUCCUCUGAGGCCAGUCCCCACAACUCAAUAUAAAUGUGUUUCCUGCAUAUAGUCAAAGUUGCCACUUCUUUUUCUUCAUAUCAUCGAUCUCUGCUCUUAAAGAUAAUCUUGGUUUUGCCUCAAACUGUUUGUCACUACAAACUUUCCCCAUGUUCCUAAGUAAAACAGGUAACUGCCUCUCAACUAUAUCAAGUAGACUAAAAUAUUGUGUCUCUAAUAUCAGAAAUUCAGCUUUAAUAUAUUGGGUUUAACUCUUUGAAAUUUAGAGUCUCCUUGAAAUACACAUGGGGGUGAUUUCCUAAACUUUAUUUCUUGUAAGGAUUUAUCUCAGGGGUAACACACAAACCAGCAUCCUGAACCUCUAAGUAUGAGGACAGUAAGCCUUAAGAAUAUAAAAUAAACUGUUCUUCUCUCUGCCGGUGGAAGUGUGCCCUGUCUAUUCCUGAAAUUGCUUGUUUGAGACGCAUGAGACGUGCAGCACAUGAGACACGUGCAGCAGCCUGUGGAAUAUUGUCAGUGAAGAAUGUCUUUGCCUGAUUAGAUAUAAAGACAAGUUAAACACAGCAUUAGACUAUAGAUCAAGCCUGUGCCAGACACAAAUGACCUAAUGCCCAGCACGGGCCACGGAAUCUCCUAUCCUCUUGCUUGAACAGAGCAGCACACUUCUCCCCCAACACUAUUAGAUGUUCUGGCAUAAUUUUGUAGAUAUGUAGGAUUUGACAUGGACUAUUGUUCAAUGAUUCAGAGGAAAUCUCCUUUGUUCAGAUAAGUACACUGACUACUAAAUGGAUUAAAAAACACAGUAAUAAAACCCAGUUUUCCCCUUAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications