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SNORD69: SNORD69 is a small nucleolar RNA (snoRNA) that has been identified in various studies [PMC9393553] [PMC6294694] [PMC8609340] [PMC8092379] [PMC8188706] [PMC9136061] [PMC9736786]. It is involved in the modification of rRNA, specifically targeting the 28S rRNA [PMC8188706]. SNORD69 has been found to be present in plasma and human cartilage, indicating its potential role in aging and osteoarthritis [PMC9393553]. It is one of the most abundant snoRNAs found in exosomes and EV-enriched sweat samples, along with SNORD20 and SNORD63 [PMC8188706]. Age-related changes have been observed in the expression of SNORD69, with significant differences found between different age groups [PMC6052399]. In addition to its role in rRNA modification, SNORD69 has also been associated with major psychiatric mood disorders and lipid/glucose abnormalities when associated with other genes such as GLT8D1 and GNL3 [PMC4382905]. Comparative analysis of SNORD69 sequences from different species has revealed variations that affect its modification guide activity on rRNA molecules such as 18S rRNA and 28S rRNA in reptiles, birds, and mammals [PMC6984369]. Overall, SNORD69 is a snoRNA that plays a significant role in RNA modification processes.
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