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snord69: SNORD69 is a small nucleolar RNA (snoRNA) of the C/D box class, which is primarily characterized by its role in guiding the 2′-O-methylation of ribosomal RNA (rRNA) [PMC8188706]. This snoRNA was identified in multiple studies, suggesting its prevalence and potential importance in various biological processes [PMC9393553]. SNORD69 was found to be one of the most abundant snoRNAs in extracellular vesicles (EVs) and was significantly present in plasma, indicating its potential as a biomarker for age-related changes [PMC9136061; PMC6052399]. It has been detected consistently across different sample types, highlighting its stability and ubiquity [PMC8188706]. SNORD69 has also been associated with major psychiatric mood disorders when found in a genomic region linked to glucose and lipid abnormalities [PMC4382905]. Comparative studies across species have shown that SNORD69 has conserved functions but also species-specific roles, as seen with its dual-guide modification activities identified in Xenopus and fish [PMC6984369]. The expression of SNORD69 has been validated through northern blot analysis, confirming its presence across different cell types [PMC6984369].
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