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hsa-mir-1249: Hsa-mir-1249 is a microRNA gene that is conserved in various sequences of NS1 genes in type 1 [PMC3521223]. It is a single-exon gene that has been screened by PCR and Sanger sequencing [PMC4549933]. Hsa-mir-1249 has been identified as one of the 16 miRNAs that contribute to the best classification accuracy [PMC2889897]. In infants with biliary atresia, hsa-mir-1249 expression levels were significantly lower [PMC4754688]. Hsa-mir-1249, along with other differentially expressed miRNAs, has been selected as a putative biomarker for further validation [PMC4754688]. It has a predicted target gene, GPR64, which is related to G-protein coupled receptor activity [PMC4754688]. Hsa-mir-1249 was found to be down-regulated in kidney tissue samples of patients with membranous nephropathy compared to healthy controls [PMC8610666]. It is one of the miRNAs identified in association with various genes related to survival differences and expression differences in TCGA database analysis [PMC7917321]. Hsa-mir-1249 was also found to have indels associated with microsatellite instability (MSI) in miRNA genes [PMC7648123].
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