Caution, this is an AI generated summary based on literature. This may have errors, see here for more.
Please share your feedback with us.
dre-miR-184: Dre-mir-184 is a microRNA that plays a role in the development and function of the retinal pigment epithelium (RPE) in zebrafish [PMC7844312]. Downregulation of dre-mir-184 leads to a decrease in the expression levels of RPE markers, while its overexpression stimulates RPE development by inhibiting the AKT2/mTOR pathway [PMC7844312]. In zebrafish embryos, the exogenous or endogenous expression of dre-mir-184 was modulated by injecting them with dre-mir-184 mimic or inhibitor [PMC5239556]. The injection of dre-mir-184 mimic resulted in robust expression of retinoid isomerohydrolase, a marker of RPE cells, while injection with dre-mir-184 inhibitor led to decreased reactivity of retinoid isomerohydrolase [PMC5239556]. The findings suggest that dre-mir-184 is important for maintaining the regular function and development of zebrafish RPE [PMC5239556]. Knocking down dre-mir-184 suppresses the expression of RPE markers, while overexpression promotes RPE development [PMC5239556]. The role of dre-mir-184 in RPE development was investigated using a zebrafish model [PMC5239556]. Dre-miR-724 and -725, along with other miRNAs such as -193a, -202, -205, and -133a, regulate various cellular processes including apoptosis and autophagy through their target genes [PMC5664119]. Dre-miR-2189 targets genes predominantly upregulated in modules such as cell cycle and apoptosis/autophagy modules [PMC5664119].
Genome locations
Gene Ontology annotations
Ancestor Chart
Loading ontology ancestors...
Failed to load QuickGO Ancestor chart
Sequence
Sequence features are shown above as colored rectangles.
Zoom in and click to view details, or
Reset