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gga-mir-133b: Gga-mir-133b is a miRNA that has been found to be prominently involved in inositol phosphate metabolism and phosphatidylinositol signaling [PMC8241840]. In a study comparing LB and NOR strains, gga-mir-133b was one of the nine upregulated miRNAs that showed enrichment in their target genes [PMC8241840]. In another study comparing WB and NOR muscles, gga-mir-133b was found to be downregulated in WB muscles [PMC8555438]. The target genes of gga-mir-133b were predicted to include collagen coding genes [PMC8555438]. Gga-mir-133b is part of the gga-miR-133 family, which is the most abundant miRNA family in breast muscle libraries [PMC4519947]. However, the expression levels of gga-miR-133a and gga-mir-133b were relatively low compared to other myomiRs in skeletal muscle libraries [PMC3107184]. Gga-mir-133b has been found to target focal adhesion genes, while other miRNAs such as gga-miR-146b-3p and gga-miR-223 target adherens junction genes [PMC6815035]. Additionally, the expression level of gga-mir-133b has been shown to increase significantly in breast muscle after chicken sexual maturity, which is known to involve fat deposition [PMC8002044].
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