mmu-mir-363: Mmu-mir-363 is a microRNA that targets the 3'-UTR of p300 mRNA and is associated with increased expression of mmu-miR-451 [PMC4114167]. Mmu-miR-451 is known to destabilize cytokine mRNAs [PMC4114167]. Tumors with retroviral integration sites within the mmu-mir-106a-363 locus showed higher expression of the primary mmu-mir-106a-363 transcript, as well as mature mmu-miR-106a and mmu-mir-363, compared to tumors with other integration sites [PMC7290785]. These tumors also exhibited increased expression levels of mmu-mir-106a and mmu-mir-363 compared to tumors without integrations in this region [PMC1794537]. The mature species of mmu-mir-106a and mmu-mir-363 were measured using qPCR in tumors with integrations in this region, and a statistically significant difference in expression was observed compared to tumor controls [PMC1794537]. The amplification efficiencies of the calibration curves for mmu-mir-106a and mmu-mir-363 were 67% and 69%, respectively [PMC1794537]. The retroviral integrations in this region also affected the expression of the mir-106a cistron, as measured by qPCR for primary transcript levels (Kis2) and mature miRNA levels (mmu-miR -106a and -363) [PMC1794537]. Overexpression of EST AI464896, which maps to the same location as mmu -mir -363, was observed in tumors with proviral MLV integrations into this region [PMC1794537]. These findings suggest that retroviral integrations within this locus can impact the expression levels of mir-106a and mir-363 [PMC1794537].