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MT-TA: MT-TA is a gene located in the mitochondrial genome, specifically in the region from nucleotide 5303 to 5803 in the revised Cambridge Reference Sequence (rCRS) [PMC1564046]. This gene, along with MT-ND2, MT-TW, and MT-NC3, is outputted from this region [PMC1564046]. The alleles of MT-TA, MT-TC, and MT-TT have been found to potentially enhance the generation of reactive oxygen species (ROS), which is a critical contributor to gouty attacks [PMC6034246]. The cycling program for a specific mutation (m.5628 T > C) in the MT-TA region involves specific temperature stages for PCR amplification [PMC6034246]. Similarly, for another mutation (m.9957 T > C) in the MT-CO3 region, specific amplification protocols are followed [PMC6034246]. The allelic discrimination plots generated from these amplification protocols are analyzed using StepOnePlus SW v2.3 software [PMC6034246].
References:
- PMC1564046
- PMC6034246
Genome locations
Gene Ontology annotations
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