Caution, this is an AI generated summary based on literature. This may have errors, see here for more.
Please share your feedback with us.
hsa-mir-18a: Hsa-mir-18a is a member of the oncogenic miR-17/92 miRNA cluster, which is frequently overexpressed and has a prognostic role in lung cancer [PMC6405743]. In primary human dermal microvascular endothelial cells (HDMEC) treated with radiation, hsa-mir-18a was found to be downregulated, along with hsa-miR-125a, hsa-miR-127, hsa-miR-148b, hsa-miR-189, and hsa-miR-503 [PMC3424689]. To investigate the role of hsa-mir-18a further, digoxigenin (Dig)-conjugated probes specific to this miRNA were used in an experiment [PMC4007194]. The study found that 324 genes were identified as targets of hsa-mir-18a [PMC8797695]. Additionally, other miRNAs such as hsa-let-7g, hsa-miR-16, hsa-miR-20a, and hsa-miR21 were upregulated in HDMEC after radiation treatment [PMC3424689]. The overexpression of the oncogenic miRNA cluster has been associated with lung cancer prognosis [PMC6405743], while the downregulation of specific miRNAs including has mir 18a may have implications in radiation response. The study also identified other genes targeted by different miRNAs such as has mir 3170 and has mir 4762 [PMC8797695]. These findings contribute to our understanding of the role of specific miRNAs like has mir 18a in cancer development and response to treatment.
mRNA interactions
6 total
Genome locations
Gene Ontology annotations
Ancestor Chart
Loading ontology ancestors...
Failed to load QuickGO Ancestor chart
Localisation
Sequence
Sequence features are shown above as colored rectangles.
Zoom in and click to view details, or
Reset