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hsa-mir-509: Hsa-mir-509 is a microRNA that has been implicated in various biological processes and diseases, including cocaine dependence, cancer, and metastasis [PMC4930134] [PMC4505902] [PMC6685408] [PMC6276827]. It has been shown that the risk allele for cocaine dependence, rs1437134G, leads to a decreased expression of NFAT5, and this effect is more pronounced in the presence of hsa-mir-509 [PMC4930134]. Additionally, rs1437134 and another variant, rs11641233, have been predicted to alter the binding of hsa-mir-509 to NFAT5 messenger RNA [PMC4930134]. Hsa-mir-509 has also been found to play a role in suppressing brain metastasis in breast cancer and pancreatic cancer patients [PMC6276827]. Furthermore, hsa-mir-509 has been shown to inhibit tumor cell invasion and migration in various cancers such as lung cancer, breast cancer, renal cell cancer, and pancreatic cancer [PMC6276827]. However, the expression level of hsa-mir-509 may not have a significant relationship with overall survival in patients with certain diseases such as glioma or gastric cancer [PMC8046546]. In summary, hsa-mir-509 is a microRNA that is involved in various biological processes and diseases. It can modulate gene expression and affect disease outcomes.
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