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bta-miR-128: Bta-mir-128, a microRNA, is part of a network of differentially expressed microRNAs (DEmiRNAs) and their target genes [PMC6720277]. It has been found to be upregulated in the L group and may play a role in rumen development by regulating the expression of PPARG and SLC16A1 [PMC6720277]. The binding site of bta-mir-128 on the 3' untranslated region (UTR) of the PPARG gene was mutated to investigate its regulatory relationship [PMC6720277]. Luciferase assays confirmed that bta-mir-128 can suppress the activity of wild-type PPARG and SLC16A1 reporter vectors, but this suppression is disrupted when mutations are introduced in the seed region of bta-mir-128 [PMC6720277]. The negative regulatory relationship between bta-mir-128 and its target genes, including PPARG and SLC16A1, was further validated by analyzing other DEmiRNAs and their target genes [PMC6720277]. Bta-mir-128 was also found to have a high betweenness in a network analysis comparing differentially expressed miRNAs at different time points [PMC9445238]. Additionally, it was identified as one of the differentially expressed miRNAs in comparisons between different groups [PMC10000098].
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