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mmu-mir-127: Mmu-mir-127 is a pri-miRNA that has been studied in various contexts. It was included in a panel of pri-miRNAs that were used to generate digoxigenin-labeled RNA-probes [PMC7904729]. Mmu-mir-127 has been reported to reside in imprinted loci in the genome and is expressed from the maternally inherited chromosome [PMC3712712]. It was omitted from further analysis due to the lack of identified targets [PMC9657954]. Mmu-mir-127 was included in a panel of TaqMan miRNA assays used for mice [PMC9657954]. In a study on lung development, overexpression of mmu-mir-127 led to impaired lung branching, indicating its essential role in lung development [PMC9657954][PMC4065842][PMC9321239]. The chr12qF1 microRNA cluster, which includes mmu-mir-127, has been found to be up-regulated in various cancer subtypes, including lung adenocarcinoma and colorectal cancer [PMC4989891][PMC4065842][PMC9321239]. The downregulation of mmu-mir-127 has been associated with upregulation of MAPK pathways [PMC9321239]. Mmu-mir-127 expression was found to be low or undetected in B cells that had experienced the germinal center (GC) reaction, suggesting its downregulation during B-cell differentiation and exit from the GC [PMC3432484][PMC3432484][PMID3432484].
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