SNORD8: SNORD8 is a small nucleolar RNA (snoRNA) that has been used as an endogenous control in various studies [PMC5893808]. It has been found to be upregulated in proliferating normal B-cells and proliferating chronic lymphocytic leukemia (CLL) cells, suggesting its functional relevance in cell proliferation [PMC9219770]. SNORD8 has also been identified as part of gene clusters involved in RNA processing and aging [PMC8845137]. Additionally, SNORD8 expression has been validated using quantitative reverse transcription PCR (qRT-PCR) in different samples, such as TC2 group and sPCL samples [PMC3511933]. Reduction of SNORD8 levels using antisense oligonucleotides (ASOs) has been shown to affect the 2'-O-methylation (2'-OMe) modification at specific positions within the U6 small nuclear RNA (snRNA), without affecting its abundance or processing [PMC9136273]. Furthermore, SNORD8 has been included in risk models for different cohorts and identified as part of signatures specific to certain subgroups of multiple myeloma patients [PMC9939161] [PMC8629011]. Overall, these studies highlight the importance of SNORD8 in various biological processes and its potential as a biomarker or therapeutic target.