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gga-mir-22: Gga-mir-22 is a microRNA that has been found to be significantly increased upon CD40L-stimulation [PMC3743212]. It is also expressed at high levels in HD11 cells [PMC3743212]. Gga-mir-22 has been shown to be differentially expressed in various infection models, including avian influenza virus infection in chicken lungs [PMC5389138], swine-origin H1N1 or avian-origin H7N7 influenza A virus infection in A549 cells [PMC5389138], and highly pathogenic H5N1 avian virus infection in cynomolgus macaques [PMC5389138]. Gga-mir-22 has also been linked to lipid metabolic genes, such as ACSL5, ELVOL6, and PLIN2, suggesting a role in regulating hepatic lipid production during egg production in chickens [PMC7936154]. In addition, gga-mir-22 has been highlighted as being differentially expressed in infected dendritic cells and showed higher expression levels in line 61 compared to line 72 birds after MDV infection [PMC9698451]. The higher expression of gga-mir-22 in line 61 birds may have a protective role against some of the symptoms associated with MDV infection [PMC9698451]. Overall, gga-mir-22 appears to play a role in immune response and lipid metabolism regulation.
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