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bta-mir-107: Bta-mir-107 is a member of the brown module and is involved in cellular processes essential for lactation and milk synthesis [PMC6164576]. The human homologue of bta-mir-107, bta-miR-26b, has been shown to play a protective role in breast cancer by promoting apoptosis through targeting SLC7A11 [PMC6164576]. In a study comparing peak and late lactation, several miRNAs were found to be differentially expressed, including bta-miR-15b, bta-mir-107, bta-miR-30b-5p, bta-miR-214, bta-miR-339b, bta-miR-375, and bta-miR-487b [PMC3498112]. The expression levels of these miRNAs were higher in late lactation compared to peak lactation tissue [PMC3498112]. However, the expression pattern of bta-mir-107 did not align with the Solexa sequencing results due to potential deviation in qRT-PCR [PMC3498112]. Despite this discrepancy, the high expression of miR-107 (bta-mir-107) led researchers to focus on its role [PMC9407703]. In terms of cellular fraction analysis for miRNA stability determination, GeNorm recommended using the geometric mean of three stable miRNAs: bta-miR103, bta-mir107, and 28 [PMC9783024]. Additionally, putative functional regulation networks were identified based on correlation patterns between different miRNAs [PMC7106649]. For example, there was a positive correlation between bta-miR24–3p and bta-mir–107 [PMC7106649].
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