hsa-mir-4486: Hsa-mir-4486 is a microRNA (miRNA) that is predicted to have binding sites on the H19 gene. The rs2839698 polymorphism, which changes a C allele to a T allele, may disrupt the binding of hsa-mir-4486, along with other miRNAs such as hsa-miR-24-1-5p, hsa-miR-566, and hsa-miR-24-2-5p. This polymorphism also creates binding sites for other miRNAs like hsa-miR-612, hsa-miR-5189, hsa-miR-1285–3p and hsa-miR-3187–5p [PMC7251175]. Another polymorphism, rs3741219 A>G, causes the gain of miRNA target sites including those for hsa-mir4486 and the loss of target sites for other miRNAs like hsa-miR24–1–5p and hsa-miR566 [PMC7062941]. SNPs located in the H19 gene may alter its promoter activity and function by affecting target miRNAs such as hsa-mir4486 [PMC6449514]. These SNPs can also change the secondary structure of H19 and disrupt its targeting effect with miRNAs like hasmi-R24–1–5p and hasmi-R566 while increasing binding sites for other miRNAs like hasmi-R612 [PMC7238363]. The rs2839689 G>A polymorphism can create binding sites for certain miRNAs while destroying others on H19 including hasmi-R4486 [PMC7220275]. These findings suggest that these genetic variations in H19 can impact its interaction with different miRNAs which may have implications in various biological processes such as cancer proliferation and metastasis [PMC6267165].