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Homo sapiens (human) long intergenic non-protein coding RNA 336 (LINC00336) secondary structure diagram

Homo sapiens (human) long intergenic non-protein coding RNA 336 (LINC00336) URS00022AE773_9606

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LINC00336: LINC00336, a nuclear long non-coding RNA (lncRNA), has been implicated in the oncogenic functions of lung cancer, particularly in the regulation of ferroptosis [PMC9177660]. Overexpression of LINC00336 has been shown to counteract the growth inhibition induced by ferroptosis inducers, erastin or RSL3, in A549 and SPC-A-1 lung cancer cells [PMC6889193]. Additionally, LINC00336 has been found to interact with ELAVL1 at the endogenous level in H358 and PC9 cells [PMC6889193]. It has been reported that LINC00336 acts as a "sponge" for microRNA 6852, thereby regulating the expression of cystathionine-β-synthase and promoting ferroptosis in lung cancer cells [PMC8357526]. In the context of chromophobe renal cell carcinoma (chRCC), LINC00336 has been identified as one of the differentially expressed lncRNAs associated with overall survival [PMC5077270]. Furthermore, higher levels of LINC00336 have been correlated with poor overall survival in patients with lung cancer [PMC6889193].

Genome locations

Gene Ontology annotations

Sequence

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AGAUGCGAGCGCCUGCGCAGGUACGCACGCUCCGCUGGAGCCUGGGGUGGCCUGGCAGUCGUGGCCGAGACGUGUUUGCUGCACUUCGGUGCGCACAGGCACUGCGGUGCCAACCUCUUGGUUCCGCCCUCCCCCCGCAGGCGCCCACGCGUGACCUCGGCCGCCCACAGGCCUUCGACUCUUCCCGGACUCCAGGUCCCAGGCCGCCCCGCUCCACCCUGCGGAUGAUGGAGACAAAGUCCCCCACAAGCCCCUCAUAUGGGGCAAGGGGGAAGGUACCACCUGGGGCGGGGCCUGGCUCCCCACUGAGCAGAGGUGCUGGCCAAGGCGCUCCCCUUAGUGAGACAAGGUUUCACCAUGUUGCCCAGGCUUUUCUCAAACUCCUGAGCUCAAGCAAUCCGCCCACCUCAGCCUCCGAAAGUGCUAGGAUUAUAGGCGUGAGCCACUGCACCCAGCCCCAGGUGGCAAGUCUUUCUGAUAGGCACUGCUCCAAAGUGAAUCACACUGUGCUAAGCCCCCGCAAGGGAGUGCCUUUGCAGCUUACAGCUGCACACUCGUCAUCUCAGGAGGUCCUUGCAACAGUCCCCUUUCACGGGUAAAGAAACUGAGGCCUCUACUCAACCUCACAGAGCAAGCUAAUGCCAGACUAAAACCUCUGGCCUCCAAACCCCAUGCCCUUUCUUUUUGUAAGCUACACAGACUGUCAGGGCAAAUGUCCACUGGAUAAAAGCAUGAGAUGAUGAAUGGACGGAAAUUAACCAAAAAGGUCAUCAACACAUUUUCAACAGAUCCAUCAAUGUGCACUCAAAGAAGCUGAGACAGGCCUAACCUUUAAAGGCUGAUGUCAAGGAAGGGGAGCAGCAGGAUGGUACUCGGUCUGACCCAGCGGGGUCGCUCCCCUGAGCCUAUGUGUGUUUGGAGUGGACGAGAAUGGGAGAGAGAUUAGAAAAACAGCAGCAUCAUGUGAAUUACAGAUGCACAGGAAAGCUUACAGCCUGUCUAGACAAAUUCACUUAUGUUACAGAUGAGGAAACUGAGGCUCAGAAAGAGGAAGGGACUUGCCCAAGGCCACAUAGCAAAGGAAUAGCAAAGUUGAGACAAAAAUAAUGGACAUUGUGACUCUGAGUCAAGUGAGAAACAGAGAGACUGAUGGAGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUUUAUGUGCAUGCAGUGUGCACUCACUCAGGGGGCCAGGGUCCUGAAUUUAGAAACACUACCACCAAGAAGGCAUUAUGCCUACCCUACCCAGGCAGUGGGGGCUGGAGCCAGGGCCUGGGGGCUGGAACCAGGGCCCAGGGCCUGGAGGGGAUGGUAAGCCUCCAGCCCCACCUUCUCCAGGAAGGGGUUGGUGGUCUGGCACGGGCCAAGCGUACCUGGCCAUCCACAAUGCUCACCUCCACCACGGUGAUCUCUGGCCGGGUAAGCAGCUCUCGGCCCUCUUGGCUGCCUAGCUUCCAGAGGCGGGACUCUUGCUGCAUUCCCAGAAGCUUCUUCAACUCCGACUCCAGGAAACCUGAGAGCCAGAGAGAUGGCAAGGGACAGGGAGAUGGCAGGGAACAGGCAGGAGUAGGAUGGAGCAGCCCACUGGGAACCCAAGGACCCGGAGGUGCAACCGCUCCCUGAGCCUCAUCCCAGCUCUGUGUGGUUCCUGCUCACCCUCAGCCACAGCCCUCUCUUCUUCCAGGACGUAGAGCCAGCCAGGUACCACCCCUCCUUCGCCCUGCCUUCCCCAGGAAGCUCACUCUUUGAGGGCCUUCUCUGGCAGCGGCAGCAUGAGAGCCUGCGUCUUCACCCACUGGGGACAGCAUGCAAAGGGCAGGUAUUUGCCCCCACCACCAACCAACUCAAGAGCCUGGAUCUGGAACCCAAACUGCCUGCACUCAAGUCCCAGCUCUGCCCAUCACUAGCUGUGUGACAUCGGGCAAGUUCUCACUGUGAACUGGAGAUGGCAAUAGGACCUACCUCAGAGUCGUAAAAUGCAGGAUUUUAUGAAAAGUGCUUAAAGAGGGUCUGCCCCAUUAAUGGCUAUGUAAAUGUGAACCACGAUUUUCAUCAUAUUAUGUAUGCUAUCACCACUAA

Taxonomic tree

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2D structure Publications