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Homo sapiens (human) small nucleolar RNA host gene 15 (SNHG15) URS0000CCE070_9606

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SNHG15: Serum exosomal lncRNA SNHG15 has been suggested as a promising diagnostic and prognostic marker in non-small cell lung cancer (NSCLC) [PMC8605147]. SNHG15 overexpression has been found to block cell proliferation in thyroid papillary carcinoma [PMC10086267]. SNHG15 has also been shown to improve papillary thyroid carcinoma (PTC) progression through the miR-200a-3p/YAP1/Hippo pathway [PMC6148237]. In osteoarthritis (OA) chondrocytes, SNHG15 overexpression promotes chondrocyte proliferation [PMC7370589]. Knockdown of SNHG15 inhibits cell proliferation and induces G0/G1 phase block in pancreatic cancer and ovarian cancer cells [PMC10086267]. SNHG15 is overexpressed in gastric cancer, NSCLC, breast cancer, and colorectal cancer (CRC), where it promotes cell proliferation [PMC6536931][PMC9942365][PMC9979449][PMC6983676]. In gastric cancer tissues, SNHG15 is highly expressed [PMC6406837]. Upregulating SNHG15 enhances drug resistance in epithelial ovarian cancer cells and breast cancer cells [PMC7711482][PMC6801192]. In NSCLC, high expression levels of SNHG15 correlate with tumor size and lymph node metastasis [PMC8605147]. In hepatocellular carcinoma (HCC), upregulation of SNHG15 weakens the suppressive effect of miR-490-3p on migration and invasion of HCC cells [PMC6801192]. Knockdown of SNHG15 ameliorates the proliferation, apoptosis, invasion abilities of osteosarcoma (OS) cells, enhances DXR sensitivity in DXR-resistant OS cells, and is involved in the regulation of osteoclast differentiation [PMC7874646][PMC7874549][PMC9206997].

Genome locations

Gene Ontology annotations

Sequence

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GGGACUACGCGGUGACGUCGAGGUGCGCGGCGCAGCGCGCGGCGUCAGUCUUGGCUGGCAGACCUGUACUCCGUACUCCGUACUUCGUAGUCGCAGCGGCGCGGUCUUCGGCAGUCUAGUCAUCCACCGCCAUCCUGGGCCCCACGUGUUGCCUGACCAUUCCUGAGCCCAGGUGGGAGCCGUGGCUGAGGUGACGGUCUCAAAGUGGAAGAGCUUACUGUCACAGCAACUCCUUUGCAAGAUGCCCCGGCCAGGAAUAGUUGCUGAACACCCCAGGCCUGCUGAGGUCCCUCCUUGAGUCUCAUGUUCAAGCAGUCUUUGUCCAUGAAACUGGGAGGCGACCGUGUUAGCUGCCAGUUCCUGACAGCCACCUCUCACCAGUGGCUUCACUCUGUGUCCCUGACCCAGCACAUGGCACAAGAGUGCCUGCCAUCCGUCAGUGUUUCUACAGCAGCAAUCCCAAGAUGCUGGAGCUAGAGGGGACCUGACCUGAGAGAAGAUACCUUCAGUGGCUGCCAGGCUGUUCCUUGGAACCUGUGCAGGGAUGAGGCCUGCCUGUGUUAAUACACCUAGUGAGGAGUGGAGCUGAAUUUGAAUGCAAGCCUUGGCACCUUAAUUGAGCAAGUUUGAAACCUCGCUUGUUGCCCUUCUGGAAGGAGUCAGGAAUUUCCAGUUCUGGGCCUGGGCUGUGGGUCUGGCAGACAGACCUCUGGCCCUAGGUUUGGGUGCCAGGUUCUCUGCUUCCAGAAUGAGAAGCUUUGCUGUGCACCAGGACCUGGGCCCUUCUGGUAUCUCCUGAAUGAAAAACAAGGGAUAUUUAAUAAAUAUGGAUUUAAAUAUGUGAAAAAAAAAAAAAAAAA

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Publications