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Homo sapiens (human) FAM181A antisense RNA 1 (FAM181A-AS1) URS0000CCDFA7_9606

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FAM181A-AS1: FAM181A-AS1 is a long non-coding RNA (lncRNA) that has been found to promote the growth of gliomas by increasing the expression of ZRANB2 through its interaction with miR-129-5p [PMC7655169]. This interaction suggests that FAM181A-AS1 acts as a sponge for miR-129-5p, preventing its binding to ZRANB2 and thereby increasing ZRANB2 expression [PMC7655169]. The upregulation of ZRANB2 by FAM181A-AS1 is believed to contribute to the growth and progression of gliomas [PMC7655169]. Furthermore, FAM181A-AS1 has been identified as a potential prognostic biomarker for glioma patients [PMC7655169]. This suggests that the expression level of FAM181A-AS1 could be used as an indicator for predicting the prognosis and outcome of glioma patients. The identification of prognostic biomarkers is crucial for guiding treatment decisions and improving patient outcomes in glioma cases [PMC7655169]. In experimental studies, biotinylated FAM181A-AS1 or a negative control was used to generate probe-coated beads by incubating them with Dynabeads M-280 Streptavidin. This technique allows for the specific capture and isolation of FAM181A-AS1 or control RNA molecules, enabling further investigation into their functional roles in glioma growth [PMC7655169]. Overall, these findings highlight the importance of FAM181A-AS1 in promoting glioma growth through its interaction with miR1295p and upregulation of ZRANB2 expression. Additionally, they suggest that FAM181A-AS1 could serve as a potential prognostic biomarker for predicting outcomes in glioma patients [PMC7655169].

Genome locations

Gene Ontology annotations

Sequence

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GUGCCAACGCCGGCGGGGCUGCAAGCAGGGCCACUCUGAGCAAGCAAGGGAGCCCAGAGCCGCUGUUGGCCCUGCCCACCAACUGGCCAGAGGGAAGGUGAGCUCCAGAAGGGAAGGGAGUUCUUUCACAGCUUUCUGUCUCUGUAUCUCCUGUGACUUGAAUGGACUCAGCACACAGCAGGCCUGAGUGAAGGAUGCUUGUGGUUGCUAUGGCUUACAUGACAACGAAUUGUCUGUAAUCCUACAGGACUAUGGCACAUGAAAGCUGGAAGCGCUUCUUUCCGACUGCAUCGCCCAGCACCAGAGCCCGAGUUCUGUAAAGCUCUGUUAAAGGCACAUGAGCUGUGCUGGCUUCAACUGCCCUGAACUUGGAUAAGCUGGGCCGCUGAUGGACCCUUCCCAACCGGUUGUUGCUGCCUUGGUUUCCCGACAGUCCACUGUGCUGACCCUGCAGCAGGGACUCCCAGCUUUGCAUCAACUCCAUUCAACACCUACUGUGUGCAGGGACCAGAGGGUGUGGAGGUGGCAUUCCCUGCUUUAUCUUGAUAAGUAAACGUUUGUCUCCUGCCCACUCAUCAGUGAAGCAGAACAACUACCUAGCAGUCUCCUGGGAGCCACCCCUCCAGAACCUCUGGAUGUCAACAGACACCAUCUACUUAUAGGAUUCAGCCAGCACAUGUGUAGACUGGAGCUGCAAGAUGGUCAUCAAAUGAAAGGAGUCCCUGGAGAAACUAUUACCUGGUCCCCACAGGAGUUAACCUGACUGCCCAAGUUCACCAGUCAGCAGCCUAGCGUGUCACCUUAAAAUUCAGUCCCAAAAGAUGGGCUGACUUCUCAUUUUAGAGAUGAAGACAGAGAGGCCCAGAGAGGGGAAGAGAUUCAUCCAAGGCAAAGCCAGGCAGAGCCAGGGGUGAGAGGCAGCAGUGAUGGCUACAGCCAUACCUUGAGUCAAGGCACUGAGACGGAGAGUGUUAGGCAUUUUGGAGAGCGGAGACAGUGAGAAGCUCAGUGCAGCGGCGAAGAGAGUUCGCUGCAGGGAGUGAGGAAAGGGGCAUUUGCAUCAUCAGCAAAAGGGCCAUUUUCACCUGCCUCAGCAUUCCAUUCCCGUGCUCCCUGACUUGGUCCUGGUGGGGCGUGCUGGGACUAUGAAGAGUUACUGCUGUGAGCGCUGCGGCCCCCCAUACCUCCACCCUAGCACCAAGGCCCUGAACAGAAUGGAUGGUGUCCACCUGCAUUGGGAAGGGCUAUCUGUCUUACAACCCAUGAGUAGAUACUAUUAGCAGCCCAUCUUAAGAUGAGGAAGCUAAGGGUCCUUCCUGAGGCAAAUCCUCAGCCGCUGUUGCACGGGCUCUAGGGGAAGCCAGCUGCCAUGUUGUGGGGAUGCUCAAGGAGCCCUGAGGAGAGGCCCAUGUGAUGAGGAGCUGAGAGGACUUGGGCCAAAAGCCAGUGGAGAAUUGAGGUCUCCUGUCAGUAGCCAUAUAAGCAAGUAUUCUGGAAGCACAUCCUCCAUUCCCAGUCAAUAUCUUAACUUCAACCUCAUGAAAGACCUUGAGCCUAGCUCAGCCACUCCCAGACUCCUGACCCACAGAUACUGUGUGAGACACCUUGAAUCACAGAUAGUUGGAGAUGAAAAGGACCUUAGAAACCAUGAGAAACACCAUGGGCGAGGAGACUGGGGAGCUCUGGAGCCAUAAACCUGGCUUCAGGUCCCAGUUCUGCCACUCACCAACUGAGUGGCCAAGGACGGCAUUUUUCAGAGAACAGGAGGGAGCUGCUUCCUUAAGUAUCGCCUGGGAUCACAUUCAGACUGGAGAUGUUGCCAGAAGCAAAUCCACCUCGGUGGGGAUUCUGGUUGACCCAGGAGACCCUCUGCUCCUGAGGGAACUGCUGAGGGGCUUGGGCUAUGACUCCAGGACCAAGAGUUUUGGGAGAGACUUUCCUUCCCUGGACAAGGAAAAGGAAGUGGAGCUACCAGCUGCUGCUCUGGGAGGCUAGAGGCUCAUCUCUCUACCAUGCACCCUUUCCGAAGCUCUGUUCUCUGAGGGCUUCUGGAAAUACCCGCUUUAAUCAGAGUUAAGCCGGAUUUGAAGGUUGCGAUGAUUAGAUGUGUCAAAAAAAUUUUACAUCUAAUAACACCCAACGCUGUCAAGAAUGUGGAAAAAAACAGACAUGUAUGCAUUGUUGAUGCGAGUGUCAAUUGGUACCCAUUUUUUGGAGGGAGUUUGCUAGUAUCAUUAGAAUGUGAAAUAGAUAUGCUUUCAGACUCAACAUUUCCACUUCUAAGAGUCAAUUCUAGAGAAAUAUGUGCACAUGGACACAAAGAGUCGGGCAUGAAGAUGUUUGCAGAAAUGUUGUUUGCAACUGCAAAAAACAGUAAAAUAAAAAGCCACCAAAUCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications