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Homo sapiens (human) long intergenic non-protein coding RNA 2190 (LINC02190) URS0000BC4404_9606

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LINC02190: LINC02190 is a long non-coding RNA (lncRNA) that has been implicated in the regulation of embryo-endometrial attachment and recurrent implantation failure (RIF) [PMC8859920]. SiRNA treatment resulted in decreased levels of LINC02190 in all groups [PMC8859920]. Overexpression of LINC02190 in Ishikawa cells led to a significant reduction in the adhesion rate of Ishikawa and JAR cells [PMC8859920]. The dual-luciferase reporter assay confirmed that LINC02190 directly regulated ITGAD mRNA expression [PMC8859920]. LINC02190 was found to bind to the 150-250 bp region of the ITGAD promoter, leading to decreased ITGAD expression and inhibition of embryo-endometrial attachment, potentially contributing to RIF [PMC8859920]. Both ITGAD mRNA and protein levels were significantly decreased in the LINC02190 group compared to the vector group [PMC8859920]. Knockdown of LINC02190 resulted in a significant increase in adhesion rate between Ishikawa and JAR cells [PMC8859920]. Overexpression of LINC02190 was shown to reduce ITGAD expression, while co-overexpression with ITGAD partially reversed the inhibition of adhesion between Ishikawa cells and JAR cells [PMC8859920]. The upregulation of LINC02190 and downregulation of ITGAD observed in RIF endometrium compared with controls suggest that high expression levels of LINC02190 may decrease ITGAD expression, leading to impaired endometrial remodeling due to inflammatory response disorder and vascularization abnormalities [PMC8859920].

Genome locations

Gene Ontology annotations

Sequence

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ACUUGGCUGAAGAUACUAAAGAGAACUAGAUGUUAUCUAGUGUUAUCCUGCUGAUCCCAAUUUCCUAUAGUUCUGGCACCAGAAAAUCCUGAAUGAUAGGUUUUUCUGAAGCUGCUGACAUCGGGUCAGCCCUCAACACCAUCACCUUUGGCCAUGUUCAGGAAGUACUCAAAGGUAACACUGGCAGCCAAGAGCAGGCCAAUCAAUGUCUGGCCACCACCCUAAUCCCACCUGGACAGUCACACCCCACCUCCCUAUGUGUGUUCGCACAGUGGGGGUGAUAUCAUGUGGGUCUGGCCUGUCCUGAGCAGAACCUGGUGUUGGGUUGUCAGAAACCCAGUGACCCAUCACGUUCACUCUUCAGAUCAUGGCUCAAAAGUCUGCAGAGCAGAGACAAGAGAUUGACAAAGAGGUGUUGAUGAGUGAGAUGUUACUGUUCUGCUCUGGAGAAGAUACUGUCAGAUAAUGUCCCGCAUUUCCAUCAGCUGGCAUGCAUGCCUUUGGACUCGGACAGGGUUCUUUGGAUUGUAGCUGAAUUUUCAAUGUUUAGUCAAUAUGGAUCUGAUCUCCGCAUGAUCUUUUUUGUGAAUGCCAACACCAUUUUGUAACUUUUUUCCAUUCUAAACAUUUUUCUUUUCACUGCCAACCCUCUGCCUUGUGAUUUUAUUGGAAAUCAAGGACCUGCUAUUAUUUGUUAAUUUGCCAUCAUUUAUGUGUAUAUUGAAAGGUACGAAACCCACAAGCACAAUGAUCAUUUUUAUUUGUUUGAAACUUCAGCAGAAUAGAUAUCUGCAUGCUUUAUGAAGUUGCUUCGAUAGCAGCCCCUGGGAUGCCAGAAAUUAGCAUUUCUUUGCUGCCAUGGGCUGAUGAUACUGCUGCUAUUAGAGAAAGUUUAGCUGUGGCACCAACUCACAGCAUUUUCAUAGAAAAAGAUUACUUGUAGCUUAUUUUAGAAGUAGGAACAUUUGGUCUAUUCGACUAGACUUGCAAUUUUAAAAAAAAAAGGUUGCAUUCAUUAAAGAAAAAAUGAAUUUAAGGUAAAAUGACAAAACCUGAUCUUUAACAUCCUGAAGGAUCUGAUACAUUAUUUUCCCUCCAACUCCAUCCCAGGCCUGGUGGUAGAACUGCUAUUUUUCCUUCUUACCUUUUAGAAAAGUAUGCAUCUAGAUUUUAUUCAAAAAUAGAAGAAACAACAGUAGAAUCAUAUAAAUAGCAAAAAUUUGAAACUCAAAAUAUUAAGCGUAAGUUACAAAAAAACAUAUAAACAACAGAAUAUGUGGGAUAAAUACCAAUUUUGAUACAAUUAGUCUGGAUUAAAAGGCUGAAAGUUCAGGUGAAGGAGCAGAGAAUGCUCCUUCAAAACCAAAAGAGAGAAAAUCUUCGUAUAAGAAGCAUGAACAUAGGAUCUACACAUCAGAAAAUUUAUAGAAGGACAGAAUUAUUUUUAAAUAAUCAAAAACUAGUCUCAUUAAAAUAAAGUAUAAUCAUCAAGGACAAAAAGAAAAUUCUACAACUUGAAAAUGGGAAAAAAAUGAAGAUUAAUUCAAAACAAAAAAUGGCGUGAACUAUGACUUUCUUCUCACUUUCUUCAUUGAUCAUCACUUAAAGCUUCUUUACUUCAUUAAACUUUUCUUACACUGCUGUGCCCAGUUAAUUCCAUGACAUUUUUUACUAAUUGGUUAAAAUUGCACUGUUACAAAUUAUUAGAGGCCCACAUUUAAUGAAUAAUUUGCCUCUAAACUUCUCCAUUGCAACAUUAACAAAAUGAAAAUUAUGAAUGCCCUUUGCAAAACAUUUCAUCUGUAACUGUCGUUUAUGAUACAUGAAAAAUCCUUGAAGGGCAAAGACAGAUUCUGAGUCUUACACACACUUUGCAAUUGACUGCCAAUUGUGGUGCUUAACCUUCUGCAGGAAGAAAUCAACAAAUGGCCAUUCAUUGUACAGAAAGAAGACAAUCCACAUAAAUCGGAGAACUAUCUGAUCAGCUUAGGCAACUGUGGAUUCCUUCCACAGCAAGCAGAGCCCAGCCUGGCUAUUCUGGGAUGGCUGCUCAUGAGCACAAAGGGGCUGACCGUGGGAAAACAGGCAGUGAUCAGUGCCAAGGUGUUCAACAGCCACCAACUGGGAUUAGGAAAAAGACGUGUAAAGAUGGAGGAGAGCGAGUAAAAUAACACAAGGUGCUCACCAGGACCAGGAUGCUUUGGGUGACUCUGGACUCAGGGGAGGAUCUGGGGGAGAGGUUGGUCCCAUGAAUGUGCUGGACCUGCUGCUUGAGCCUGUGCAGGAUAAAAACCAUGGAGCCACUGGCCAAGGCCAUGAGCCCCAAACACAAAACAUCAAGGGAUGAUAACAAGACAAUAUGUAAUGACUGUAGAAUUCUGCUCCUACCUCUUCCAGAACAAUACUUAUAAUCAUUUGUCUUUGUGCUAUUUAUGCUGUUCCACUUGCCAGUCACAUGUAGAGGAACAGUAAUAUUUACCAGCGUGUUCAGAAUCCAGCACAGGACCAGGAUGUUGAAGGACCUGAUGUAUCUGGGAGCAUGUAGUUUAAGCUGUGCCCACCUGAAUUCGCUGGGGCUGAUGGUGAUGACCUGGAAGACACUCAGGAGGCAGGCAUUGCCAACGCACACAGCCCUGCCCACUCUGUGAACAUAAAACACAAGUUUGCAUCCAAUAUCACUGAGGGAAUCUUUCGACCCAAAAGCAGCCAUUGUUUGUGGGAUUCCUUUAGAGUAUAACCUAGGAGUUGGCUAUGGUCAGGUGCUUGAGAAUCAGAUCUGUGGACCAUAACAUACCUCUGGUGAAACAAAGGAAACUAUAGUGGUAAAGAAGAAAGAAAUUCCCCAGGAAUCCAACUAUGAUCUGAGAUAAGAAGAUCAUGCCUAUUGAAAAAUCCCUGGAGGCCAUUUGUCAUUUUUCAGUGUCUGAUAAUUACAUUCAAAGUGAGAGAACCCUGCGUGGAAACAUAAACUCUGUUUCACUUUUGCAAAUAAAAUCCACUAUUGUCCACUUAC

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Publications