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Homo sapiens (human) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) URS0000A77400_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

MALAT1: MALAT1, a long non-coding RNA (lncRNA), has been extensively studied in various diseases, including osteoporosis [PMC10059267]. It is highly expressed in proliferating and differentiating myoblasts [PMC6755471]. Researchers have systematically screened for therapeutic approaches targeting MALAT1 and its associated factors, such as KDM5B, to improve clinical outcomes [PMC4768424]. MALAT1 has been implicated in various cancers, including osteosarcoma and breast cancer, where it promotes cell proliferation and metastasis through the PI3K/AKT signaling pathway [PMC6006327] [PMC6110141] [PMC8349266]. It has also been suggested that MALAT1 modulates the expression of genes involved in cell cycle regulation [PMC7531330]. In HIV-1 infection, MALAT1 expression is up-regulated and associated with viral reactivation [PMC6451131]. Additionally, MALAT1 has been implicated in hepatocellular carcinoma (HCC) progression through mTOR activation and SRSF1 elevation [PMC8352691]. In drug resistance studies, MALAT1 has been shown to alter drug distribution by regulating ABC proteins [PMC9960193]. Furthermore, downregulation of MALAT1 expression alleviates neuronal apoptosis and inhibits HIV-1 transcription by preventing polycomb repressive complex 2-mediated H3K27me3 at the HIV- 5′-LTR promoter region[ PMC8635732] . Overall, these studies highlight the diverse roles of MALAT1 in various diseases and its potential as a therapeutic target.

mRNA interactions 9 total

Genome locations

Gene Ontology annotations

Localisation

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset 

CGCAGCCUGCAGCCCGAGACUUCUGUAAAGGACUGGGGCCCCGCAACUGGCCUCUCCUGCCCUCUUAAGCGCAGCGCCAUUUUAGCAACGCAGAAGCCCGGCGCCGGGAAGCCUCAGCUCGCCUGAAGGCAGGUCCCCUCUGACGCCUCCGGGAGCCCAGGUUUCCCAGAGUCCUUGGGACGCAGCGACGAGUUGUGCUGCUAUCUUAGCUGUCCUUAUAGGCUGGCCAUUCCAGGUGGUGGUAUUUAGAUAAAACCACUCAAACUCUGCAGUUUGGUCUUGGGGUUUGGAGGAAAGCUUUUAUUUUUCUUCCUGCUCCGGUUCAGAAGGUCUGAAGCUCAUACCUAACCAGGCAUAACACAGAAUCUGCAAAACAAAAACCCCUAAAAAAGCAGACCCAGAGCAGUGUAAACACUUCUGGGUGUGUCCCUGACUGGCUGCCCAAGGUCUCUGUGUCUUCGGAGACAAAGCCAUUCGCUUAGUUGGUCUACUUUAAAAGGCCACUUGAACUCGCUUUCCAUGGCGAUUUGCCUUGUGAGCACUUUCAGGAGAGCCUGGAAGCUGAAAAACGGUAGAAAAAUUUCCGUGCGGGCCGUGGGGGGCUGGCGGCAACUGGGGGGCCGCAGAUCAGAGUGGGCCACUGGCAGCCAACGGCCCCCGGGGCUCAGGCGGGGAGCAGCUCUGUGGUGUGGGAUUGAGGCGUUUUCCAAGAGUGGGUUUUCACGUUUCUAAGAUUUCCCAAGCAGACAGCCCGUGCUGCUCCGAUUUCUCGAACAAAAAAGCAAAACGUGUGGCUGUCUUGGGAGCAAGUCGCAGGACUGCAAGCAGUUGGGGGAGAAAGUCCGCCAUUUUGCCACUUCUCAACCGUCCCUGCAAGGCUGGGGCUCAGUUGCGUAAUGGAAAGUAAAGCCCUGAACUAUCACACUUUAAUCUUCCUUCAAAAGGUGGUAAACUAUACCUACUGUCCCUCAAGAGAACACAAGAAGUGCUUUAAGAGGUAUUUUAAAAGUUCCGGGGGUUUUGUGAGGUGUUUGAUGACCCGUUUAAAAUAUGAUUUCCAUGUUUCUUUUGUCUAAAGUUUGCAGCUCAAAUCUUUCCACACGCUAGUAAUUUAAGUAUUUCUGCAUGUGUAGUUUGCAUUCAAGUUCCAUAAGCUGUUAAGAAAAAUCUAGAAAAGUAAAACUAGAACCUAUUUUUAACCGAAGAACUACUUUUUGCCUCCCUCACAAAGGCGGCGGAAGGUGAUCGAAUUCCGGUGAUGCGAGUUGUUCUCCGUCUAUAAAUACGCCUCGCCCGAGCUGUGCGGUAGGCAUUGAGGCAGCCAGCGCAGGGGCUUCUGCUGAGGGGGCAGGCGGAGCUUGAGGAAACCGCAGAUAAGUUUUUUUCUCUUUGAAAGAUAGAGAUUAAUACAACUACUUAAAAAAUAUAGUCAAUAGGUUACUAAGAUAUUGCUUAGCGUUAAGUUUUUAACGUAAUUUUAAUAGCUUAAGAUUUUAAGAGAAAAUAUGAAGACUUAGAAGAGUAGCAUGAGGAAGGAAAAGAUAAAAGGUUUCUAAAACAUGACGGAGGUUGAGAUGAAGCUUCUUCAUGGAGUAAAAAAUGUAUUUAAAAGAAAAUUGAGAGAAAGGACUACAGAGCCCCGAAUUAAUACCAAUAGAAGGGCAAUGCUUUUAGAUUAAAAUGAAGGUGACUUAAACAGCUUAAAGUUUAGUUUAAAAGUUGUAGGUGAUUAAAAUAAUUUGAAGGCGAUCUUUUAAAAAGAGAUUAAACCGAAGGUGAUUAAAAGACCUUGAAAUCCAUGACGCAGGGAGAAUUGCGUCAUUUAAAGCCUAGUUAACGCAUUUACUAAACGCAGACGAAAAUGGAAAGAUUAAUUGGGAGUGGUAGGAUGAAACAAUUUGGAGAAGAUAGAAGUUUGAAGUGGAAAACUGGAAGACAGAAGUACGGGAAGGCGAAGAAAAGAAUAGAGAAGAUAGGGAAAUUAGAAGAUAAAAACAUACUUUUAGAAGAAAAAAGAUAAAUUUAAACCUGAAAAGUAGGAAGCAGAAGAAAAAAGACAAGCUAGGAAACAAAAAGCUAAGGGCAAAAUGUACAAACUUAGAAGAAAAUUGGAAGAUAGAAACAAGAUAGAAAAUGAAAAUAUUGUCAAGAGUUUCAGAUAGAAAAUGAAAAACAAGCUAAGACAAGUAUUGGAGAAGUAUAGAAGAUAGAAAAAUAUAAAGCCAAAAAUUGGAUAAAAUAGCACUGAAAAAAUGAGGAAAUUAUUGGUAACCAAUUUAUUUUAAAAGCCCAUCAAUUUAAUUUCUGGUGGUGCAGAAGUUAGAAGGUAAAGCUUGAGAAGAUGAGGGUGUUUACGUAGACCAGAACCAAUUUAGAAGAAUACUUGAAGCUAGAAGGGGAAGUUGGUUAAAAAUCACAUCAAAAAGCUACUAAAAGGACUGGUGUAAUUUAAAAAAAACUAAGGCAGAAGGCUUUUGGAAGAGUUAGAAGAAUUUGGAAGGCCUUAAAUAUAGUAGCUUAGUUUGAAAAAUGUGAAGGACUUUCGUAACGGAAGUAAUUCAAGAUCAAGAGUAAUUACCAACUUAAUGUUUUUGCAUUGGACUUUGAGUUAAGAUUAUUUUUUAAAUCCUGAGGACUAGCAUUAAUUGACAGCUGACCCAGGUGCUACACAGAAGUGGAUUCAGUGAAUCUAGGAAGACAGCAGCAGACAGGAUUCCAGGAACCAGUGUUUGAUGAAGCUAGGACUGAGGAGCAAGCGAGCAAGCAGCAGUUCGUGGUGAAGAUAGGAAAAGAGUCCAGGAGCCAGUGCGAUUUGGUGAAGGAAGCUAGGAAGAAGGAAGGAGCGCUAACGAUUUGGUGGUGAAGCUAGGAAAAAGGAUUCCAGGAAGGAGCGAGUGCAAUUUGGUGAUGAAGGUAGCAGGCGGCUUGGCUUGGCAACCACACGGAGGAGGCGAGCAGGCGUUGUGCGUAGAGGAUCCUAGACCAGCAUGCCAGUGUGCCAAGGCCACAGGGAAAGCGAGUGGUUGGUAAAAAUCCGUGAGGUCGGCAAUAUGUUGUUUUUCUGGAACUUACUUAUGGUAACCUUUUAUUUAUUUUCUAAUAUAAUGGGGGAGUUUCGUACUGAGGUGUAAAGGGAUUUAUAUGGGGACGUAGGCCGAUUUCCGGGUGUUGUAGGUUUCUCUUUUUCAGGCUUAUACUCAUGAAUCUUGUCUGAAGCUUUUGAGGGCAGACUGCCAAGUCCUGGAGAAAUAGUAGAUGGCAAGUUUGUGGGUUUUUUUUUUUUACACGAAUUUGAGGAAAACCAAAUGAAUUUGAUAGCCAAAUUGAGACAAUUUCAGCAAAUCUGUAAGCAGUUUGUAUGUUUAGUUGGGGUAAUGAAGUAUUUCAGUUUUGUGAAUAGAUGACCUGUUUUUACUUCCUCACCCUGAAUUCGUUUUGUAAAUGUAGAGUUUGGAUGUGUAACUGAGGCGGGGGGGAGUUUUCAGUAUUUUUUUUUGUGGGGGUGGGGGCAAAAUAUGUUUUCAGUUCUUUUUCCCUUAGGUCUGUCUAGAAUCCUAAAGGCAAAUGACUCAAGGUGUAACAGAAAACAAGAAAAUCCAAUAUCAGGAUAAUCAGACCACCACAGGUUUACAGUUUAUAGAAACUAGAGCAGUUCUCACGUUGAGGUCUGUGGAAGAGAUGUCCAUUGGAGAAAUGGCUGGUAGUUACUCUUUUUUCCCCCCACCCCCUUAAUCAGACUUUAAAAGUGCUUAACCCCUUAAACUUGUUAUUUUUUACUUGAAGCAUUUUGGGAUGGUCUUAACAGGGAAGAGAGAGGGUGGGGGAGAAAAUGUUUUUUUCUAAGAUUUUCCACAGAUGCUAUAGUACUAUUGACAAACUGGGUUAGAGAAGGAGUGUACCGCUGUGCUGUUGGCACGAACACCUUCAGGGACUGGAGCUGCUUUUAUCCUUGGAAGAGUAUUCCCAGUUGAAGCUGAAAAGUACAGCACAGUGCAGCUUUGGUUCAUAUUCAGUCAUCUCAGGAGAACUUCAGAAGAGCUUGAGUAGGCCAAAUGUUGAAGUUAAGUUUUCCAAUAAUGUGACUUCUUAAAAGUUUUAUUAAAGGGGAGGGGCAAAUAUUGGCAAUUAGUUGGCAGUGGCCUGUUACGGUUGGGAUUGGUGGGGUGGGUUUAGGUAAUUGUUUAGUUUAUGAUUGCAGAUAAACUCAUGCCAGAGAACUUAAAGUCUUAGAAUGGAAAAAGUAAAGAAAUAUCAACUUCCAAGUUGGCAAGUAACUCCCAAUGAUUUAGUUUUUUUCCCCCCAGUUUGAAUUGGGAAGCUGGGGGAAGUUAAAUAUGAGCCACUGGGUGUACCAGUGCAUUAAUUUGGGCAAGGAAAGUGUCAUAAUUUGAUACUGUAUCUGUUUUCCUUCAAAGUAUAGAGCUUUUGGGGAAGGAAAGUAUUGAACUGGGGGUUGGUCUGGCCUACUGGGCUGACAUUAACUACAAUUAUGGGAAAUGCAAAAGUUGUUUGGAUAUGGUAGUGUGUGGUUCUCUUUUGGAAUUUUUUUCAGGUGAUUUAAUAAUAAUUUAAAACUACUAUAGAAACUGCAGAGCAAAGGAAGUGGCUUAAUGAUCCUGAAGGGAUUUCUUCUGAUGGUAGCUUUUGUAUUAUCAAGUAAGAUUCUAUUUUCAGUUGUGUGUAAGCAAGUUUUUUUUUAGUGUAGGAGAAAUACUUUUCCAUUGUUUAACUGCAAAACAAGAUGUUAAGGUAUGCUUCAAAAAUUUUGUAAAUUGUUUAUUUUAAACUUAUCUGUUUGUAAAUUGUAACUGAUUAAGAAUUGUGAUAGUUCAGCUUGAAUGUCUCUUAGAGGGUGGGCUUUUGUUGAUGAGGGAGGGGAAACUUUUUUUUUUUCUAUAGACUUUUUUCAGAUAACAUCUUCUGAGUCAUAACCAGCCUGGCAGUAUGAUGGCCUAGAUGCAGAGAAAACAGCUCCUUGGUGAAUUGAUAAGUAAAGGCAGAAAAGAUUAUAUGUCAUACCUCCAUUGGGGAAUAAGCAUAACCCUGAGAUUCUUACUACUGAUGAGAACAUUAUCUGCAUAUGCCAAAAAAUUUUAAGCAAAUGAAAGCUACCAAUUUAAAGUUACGGAAUCUACCAUUUUAAAGUUAAUUGCUUGUCAAGCUAUAACCACAAAAAUAAUGAAUUGAUGAGAAAUACAAUGAAGAGGCAAUGUCCAUCUCAAAAUACUGCUUUUACAAAAGCAGAAUAAAAGCGAAAAGAAAUGAAAAUGUUACACUACAUUAAUCCUGGAAUAAAAGAAGCCGAAAUAAAUGAGAGAUGAGUUGGGAUCAAGUGGAUUGAGGAGGCUGUGCUGUGUGCCAAUGUUUCGUUUGCCUCAGACAGGUAUCUCUUCGUUAUCAGAAGAGUUGCUUCAUUUCAUCUGGGAGCAGAAAACAGCAGGCAGCUGUUAACAGAUAAGUUUAACUUGCAUCUGCAGUAUUGCAUGUUAGGGAUAAGUGCUUAUUUUUAAGAGCUGUGGAGUUCUUAAAUAUCAACCAUGGCACUUUCUCCUGACCCCUUCCCUAGGGGAUUUCAGGAUUGAGAAAUUUUUCCAUCGAGCCUUUUUAAAAUUGUAGGACUUGUUCCUGUGGGCUUCAGUGAUGGGAUAGUACACUUCACUCAGAGGCAUUUGCAUCUUUAAAUAAUUUCUUAAAAGCCUCUAAAGUGAUCAGUGCCUUGAUGCCAACUAAGGAAAUUUGUUUAGCAUUGAAUCUCUGAAGGCUCUAUGAAAGGAAUAGCAUGAUGUGCUGUUAGAAUCAGAUGUUACUGCUAAAAUUUACAUGUUGUGAUGUAAAUUGUGUAGAAAACCAUUAAAUCAUUCAAAAUAAUAAACUAUUUUUAUUAGAGAAUGUAUACUUUUAGAAAGCUGUCUCCUUAUUUAAAUAAAAUAGUGUUUGUCUGUAGUUCAGUGUUGGGGCAAUCUUGGGGGGGAUUCUUCUCUAAUCUUUCAGAAACUUUGUCUGCGAACACUCUUUAAUGGACCAGAUCAGGAUUUGAGCGGAAGAACGAAUGUAACUUUAAGGCAGGAAAGACAAAUUUUAUUCUUCAUAAAGUGAUGAGCAUAUAAUAAUUCCAGGCACAUGGCAAUAGAGGCCCUCUAAAUAAGGAAUAAAUAACCUCUUAGACAGGUGGGAGAUUAUGAUCAGAGUAAAAGGUAAUUACACAUUUUAUUUCCAGAAAGUCAGGGGUCUAUAAAUUGACAGUGAUUAGAGUAAUACUUUUUCACAUUUCCAAAGUUUGCAUGUUAACUUUAAAUGCUUACAAUCUUAGAGUGGUAGGCAAUGUUUUACACUAUUGACCUUAUAUAGGGAAGGGAGGGGGUGCCUGUGGGGUUUUAAAGAAUUUUCCUUUGCAGAGGCAUUUCAUCCUUCAUGAAGCCAUUCAGGAUUUUGAAUUGCAUAUGAGUGCUUGGCUCUUCCUUCUGUUCUAGUGAGUGUAUGAGACCUUGCAGUGAGUUUAUCAGCAUACUCAAAAUUUUUUUCCUGGAAUUUGGAGGGAUGGGAGGAGGGGGUGGGGCUUACUUGUUGUAGCUUUUUUUUUUUUUACAGACUUCACAGAGAAUGCAGUUGUCUUGACUUCAGGUCUGUCUGUUCUGUUGGCAAGUAAAUGCAGUACUGUUCUGAUCCCGCUGCUAUUAGAAUGCAUUGUGAAACGACUGGAGUAUGAUUAAAAGUUGUGUUCCCCAAUGCUUGGAGUAGUGAUUGUUGAAGGAAAAAAUCCAGCUGAGUGAUAAAGGCUGAGUGUUGAGGAAAUUUCUGCAGUUUUAAGCAGUCGUAUUUGUGAUUGAAGCUGAGUACAUUUUGCUGGUGUAUUUUUAGGUAAAAUGCUUUUUGUUCAUUUCUGGUGGUGGGAGGGGACUGAAGCCUUUAGUCUUUUCCAGAUGCAACCUUAAAAUCAGUGACAAGAAACAUUCCAAACAAGCAACAGUCUUCAAGAAAUUAAACUGGCAAGUGGAAAUGUUUAAACAGUUCAGUGAUCUUUAGUGCAUUGUUUAUGUGUGGGUUUCUCUCUCCCCUCCCUUGGUCUUAAUUCUUACAUGCAGGAACACUCAGCAGACACACGUAUGCGAAGGGCCAGAGAAGCCAGACCCAGUAAGAAAAAAUAGCCUAUUUACUUUAAAUAAACCAAACAUUCCAUUUUAAAUGUGGGGAUUGGGAACCACUAGUUCUUUCAGAUGGUAUUCUUCAGACUAUAGAAGGAGCUUCCAGUUGAAUUCACCAGUGGACAAAAUGAGGAAAACAGGUGAACAAGCUUUUUCUGUAUUUACAUACAAAGUCAGAUCAGUUAUGGGACAAUAGUAUUGAAUAGAUUUCAGCUUUAUGCUGGAGUAACUGGCAUGUGAGCAAACUGUGUUGGCGUGGGGGUGGAGGGGUGAGGUGGGCGCUAAGCCUUUUUUUAAGAUUUUUCAGGUACCCCUCACUAAAGGCACCGAAGGCUUAAAGUAGGACAACCAUGGAGCCUUCCUGUGGCAGGAGAGACAACAAAGCGCUAUUAUCCUAAGGUCAAGAGAAGUGUCAGCCUCACCUGAUUUUUAUUAGUAAUGAGGACUUGCCUCAACUCCCUCUUUCUGGAGUGAAGCAUCCGAAGGAAUGCUUGAAGUACCCCUGGGCUUCUCUUAACAUUUAAGCAAGCUGUUUUUAUAGCAGCUCUUAAUAAUAAAGCCCAAAUCUCAAGCGGUGCUUGAAGGGGAGGGAAAGGGGGAAAGCGGGCAACCACUUUUCCCUAGCUUUUCCAGAAGCCUGUUAAAAGCAAGGUCUCCCCACAAGCAACUUCUCUGCCACAUCGCCACCCCGUGCCUUUUGAUCUAGCACAGACCCUUCACCCCUCACCUCGAUGCAGCCAGUAGCUUGGAUCCUUGUGGGCAUGAUCCAUAAUCGGUUUCAAGGUAACGAUGGUGUCGAGGUCUUUGGUGGGUUGAACUAUGUUAGAAAAGGCCAUUAAUUUGCCUGCAAAUUGUUAACAGAAGGGUAUUAAAACCACAGCUAAGUAGCUCUAUUAUAAUACUUAUCCAGUGACUAAAACCAACUUAAACCAGUAAGUGGAGAAAUAACAUGUUCAAGAACUGUAAUGCUGGGUGGGAACAUGUAACUUGUAGACUGGAGAAGAUAGGCAUUUGAGUGGCUGAGAGGGCUUUUGGGUGGGAAUGCAAAAAUUCUCUGCUAAGACUUUUUCAGGUGAACAUAACAGACUUGGCCAAGCUAGCAUCUUAGCGGAAGCUGAUCUCCAAUGCUCUUCAGUAGGGUCAUGAAGGUUUUUCUUUUCCUGAGAAAACAACACGUAUUGUUUUCUCAGGUUUUGCUUUUUGGCCUUUUUCUAGCUUAAAAAAAAAAAAAGCAAAAGAUGCUGGUGGUUGGCACUCCUGGUUUCCAGGACGGGGUUCAAAUCCCUGCGGCGUCUUUGCUUUGACUACUAAUCUGUCUUCAGGACUCUUUCUGUAUUUCUCCUUUUCUCUGCAGGUGCUAGUUCUUGGAGUUUUGGGGAGGUGGGAGGUAACAGCACAAUAUCUUUGAACUAUAUACAUCCUUGAUGUAUAAUUUGUCAGGAGCUUGACUUGAUUGUAUAUUCAUAUUUACACGAGAACCUAAUAUAACUGCCUUGUCUUUUUCAGGUAAUAGCCUGCAGCUGGUGUUUUGAGAAGCCCUACUGCUGAAAACUUAACAAUUUUGUGUAAUAAAAAUGGAGAAGCUCUAAAUUGUUGUGGUUCUUUUGUGAAUAAAAAAAUCUUGAUUGGGGAAAAAA

Taxonomic tree

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Publications