v24

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Homo sapiens (human) F11 antisense RNA 1 (F11-AS1) URS0000A76B84_9606

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F11-AS1: F11-AS1 is a long non-coding RNA (lncRNA) that has been studied in various cancer types. HCC patients with low expression levels of F11-AS1 and LINC01018 and low-grade glioma and glioblastoma multiforme patients with low expression levels of MIR325HG had a worse prognosis (Xu et al., 2021b) [PMC9326028]. Additionally, F11-AS1 was found to be up-regulated in pancreatic cancer (PC) patients and its overexpression was associated with lower overall survival (Xu et al., 2021b) [PMC9205881]. The low expression of F11-AS1 was also correlated with poor prognosis in patients with HBV-related HCC, through the regulation of the miR-211-5p/NR1I3 pathway (Xu et al., 2021b) [PMC9170944]. F11-AS1 targets miR-3146 and promotes the expression of phosphatase and tensin homolog (PTEN), which is involved in the PI3K/AKT pathway (Xu et al., 2021b) [PMC9916911]. Furthermore, F11-AS1 has been identified as one of the significant high-risk factors for poor prognosis in PC patients, along with other lncRNAs such as CACNA1G-AS1, NNT-AS1, and MSC-AS1 (Xu et al., 2021b) [PMC9205881]. It has also been included in a signature of seven lncRNAs associated with cancer progression, reported by Liu et al. (2018) [PMC7563210]. Additionally, a negative correlation was observed between F11 ASI expression levels and specific DNA methylation changes in PC patients (Xu et al., 2021b) [PMC9205881].

Genome locations

Gene Ontology annotations

Sequence

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AACUGUGCCUCACGUUCCUUCCAACGGCGCCUUCCAUCCCAGCUGGGCGGGGCUUCGCCGUGUUACCUUCUCAACAUGGCGAGCUUGCUGGACGUCACGUCGCCUUCGCCUUUUCCGCUGCGGACUCUGCUCACCGACCUCCUCAGUAGAGCCGGCCCUGCUCACUACCGCGCCCACGUGUCCUGUUGUGCUUCAUUCCCACAGGCCGCAUAAGAAGUGGGUGCCGAGGCUCCCUUCCCACUGCCAUUCCACUGGCCCAGAGGAAGCUUCUGUUGUGUUCAGAUGGGCAGGCACUCUUCCUCGAGAAGUUAAGUAGCCGGAAUAUCUAAAUGCCUCUCCUUGGCGAUUACUCGAUGAGCGCCUGUCCUUCCUCCACUCUUCCAGCAGACCUGCCUUUUGGGGCUGAUGGAAAUAUGCAUAUUAGAUUAUCUGCAGAAACUGGCUCAGCACUACAAGGAGGCUGCCAACAUGAAGACACUGGAUGCGGAAUCAGGAGGAGAUGUAUACAGCUCAGUCUCCAAAGCCAGGACAAGCCAGCUCCAACACACUACUGGCUGAAUCUCACCAAUCGUUAUAGUUUUGUUUUUUGUUUUUUUAAAUGUAUUUAAGCAUUUUUAGGUGUUUUAAAUUUUAUGUGUGUAUUCUAGGAAUAUGUACUCAGAUUCUUUCAUUAGGCAUGUGUUAUUAACAACAUUCAUCUUCUUAAAGGCUGAACCAACUUUGCGCGUUUUAUCAACAGAUAUUCACUGAGCACCUAAUAUUGCCAGGCUGUGCUCAAGGCAGUGGGAUUCAUCAGUGAACAAUACAGACAAAAAUCACUGACCUAAAUGGAGCUUGAAGUUUAUAUCUAAAUCAUUCAAAGAUUCUGUGGUGGAAAAGAAGUUAGAAAUCUUUCAGCUGCAAAACAUAAGCCAAAAUACAACUCACCUUUGGAAUCAGAGAACUUACAGGUUCAUAAAAUUGCGAAGCCCAGAUGUGCACCUGAGGUGAGACUUCGUCCAGCUUCUGUCUGUGUCACUAAUCUUUCCUGCUUUCAGCGGCAUCCCUCGCAGGCCCGUGUUGUUCCCAACUGGUGUUCCCACCUGGCGGCAAACUGGUGACUGUAGUUACAGAUCUUCAACAUCACACUCAGGAGAAGAAGGAGAUUGCUUUUCAGGAGCUCCUGCAAGCCGGAGAAUAAAAGCUCUUAUUUAUUCAGAAGCCCUAAAACAUACCACCUUGGCUAUAGACUAUUUGGACAUUUCUAAGCAAAUCUGUCUGCAAAGGUGCUGAGCUGUGUUGAUCAACUGAAGCCCGUGACGUCUCAUCCUUGCAGUUGGAGCAAAUCUCAAAGGCAAAGCCAGUGUUAAGGAGAGGGAAAUCAGACUUCAUCUUUCGAUGGGAGAAGAAAAGAGUUUGCAACUGUCUCUAUUCUGCCACUGGCAGAGAAUCCAUAGGUUUGCUAAGGAUACAGAGCCACAUUGAAAAGAUAAACCUUGCUAUGCUGGAGAUUACUUAGGUGGGCCAGGAUUUCUUGAAACCAAAACUUUACUGAAUCACCUCUUCACCAUCUGUAUGCCGUGCAUUUGCUGAGAGAUAAAAACAUUCCUGUGAAAGAUGCCCUUCCCUGCACCGGGAGAAAAGAAGCAUUCUGCGACCAGGAGCCAUAGCGAAGAUAAUUCUGUAGAAACAGACCGUGGUAAAAUAAUGCCUAUCUUCCUGCAGCCUCCCCACGUAAUUUAGUUACUUUUCCACAGCUGCUUCUUUUUGCUCAACCUAAUAUCAAAGCAGUUAGGUAUUGCCAUUUCUUUGGGUCUUCAUUUUCUUAUUCAGGCUCCUGUGCCAUGUAAAACCUCUAUUAAAUUUGUAUGAUUUUCUCCUG

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Publications