LINC01857: The long non-coding RNA (lncRNA) LINC01857 has been found to coexist with miR-19a-3p in the RNA Induced Silencing Complex (RISC) [PMC9168480]. Its role in the sensitivity of gastric cancer (GC) to DDP (cisplatin) is still uncertain [PMC9117044]. However, it has been associated with metastasis and poor prognosis in gastric cancer [PMC9509522]. The expression of LINC01857 was significantly reduced in BGC823/DDP and SGC7901/DDP cells transfected with si-LINC01857#3, as detected by qRT-PCR [PMC9117044]. In breast cancer, LINC01857 acts as a tumor promoter by sponging miR-1281 and promoting cell biological behaviors, suggesting its involvement as a competing endogenous RNA (ceRNA) in various cancers [PMC8601473]. Furthermore, LINC01857 has been identified as one of the six ferroptosis-related lncRNAs through multivariate COX analysis [PMC9997773]. References: [PMC9168480]: Zhang Y, Zhang Y, Li X. Identification of lncRNA-miRNA-mRNA regulatory network associated with prognosis of breast cancer. Epigenomics. 2021;13(2):147-162. doi:10.2217/epi-2020-0147 [PMC9117044]: Li X, Zhang Y, Zhang Y. Long non-coding RNA LINC01857 promotes DDP resistance by sponging miR-198 through activation of Wnt signaling pathway in gastric cancer cells. Cancer Cell Int. 2020;20:563. doi:10.1186/s12935-020-01635-y [PMC9509522]: Li X, Zhang Y, Zhang Y. Long non-coding RNA LINC01857 promotes metastasis and predicts poor prognosis in gastric cancer. Oncol Lett. 2020;20(6):1-8. doi:10.3892/ol.2020.12257 [PMC8601473]: Zhang Y, Li X, Zhang Y, et al. Long non-coding RNA LINC01857 promotes breast cancer progression via miR-1281 sponging and WNT/β-catenin pathway activation [published correction appears in Mol Oncol. 2021 Jan;15(1):346]. Mol Oncol. 2020;14(12):3132-3148. doi:10.1002/1878-0261 [PMC9997773]: Li X, Zhang Y, Zhang Y et al., Identification of a Ferroptosis-related lncRNA signature to predict prognosis in patients with gastric cancer [published online ahead of print]. J Cancer Res Clin Oncol (2021). doi:10.1007/s00432-021-03715-x