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Homo sapiens (human) papillary thyroid carcinoma susceptibility candidate 1 (PTCSC1) URS00008B234E_9606

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PTCSC1: Papillary thyroid carcinoma susceptibility candidate 1 (PTCSC1) is a long non-coding RNA (lncRNA) located in locus 8q24 and has been identified as a predisposing locus for papillary thyroid carcinoma (PTC) [PMC8918666]. PTCSC1 is one of several lncRNAs implicated in thyroid cancer and is significantly down-regulated in thyroid tumors, suggesting a role as a tumor suppressor [PMC8373968] [PMC9095586]. PTCSC1 has also been found to be upregulated in esophageal squamous cell carcinoma (ESCC) tissues and cells, indicating its potential as a therapeutic target for ESCC treatment [PMC9031703]. PTCSC1 has been shown to activate the Akt signaling pathway, promoting cell proliferation, migration, and invasion in ESCC cells [PMC9031703]. In addition to its role in PTC and ESCC, PTCSC1 has also been implicated in the pathogenesis of other malignancies such as melanoma [PMC7960606]. Furthermore, PTCSC1 is part of a class of lncRNAs called papillary thyroid cancer susceptibility candidates (PTCSCs), which may predispose individuals to thyroid cancer [PMC5787447]. Other lncRNAs associated with thyroid cancer include BANCR, FALEC, CNALPTC1, PVT1, NAMA, PTCSC2, PTCSC3, TNRC6C-AS110–21 [PMC8373968] and CASC2,PANDAR,MALAT1,PVT1,BANCR,HOTAIR,MALAT1,HOTAIR,MALAT2,PVT2,BANCR[PMC8268647].

Genome locations

Gene Ontology annotations

Sequence

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UUUGUCACUUCCAGUGCCCUGCCCAGCCCUACAGAAAAUACGUGAUUAUUUAAGGGUGAAGAAGCCAAAGCUGGGAGAGUUUUAGUCACCUAUCUAGGGGAAAGUGUGAAGAUUUCAAAGCCCAGGGUCCUUCACGGAGCCACACGGCUCUCCUUGGCACUUAAUCUUCAAGCUCUCCUCAGCCCACACUUGACCCUUAACAGGGGAGACAAAGGCAGACUCCAGGUAAGUUGUCAGGGUUAGCAUAAGCAGCUCAGGGCAACUGGUGGGUAGGGAGCUGUACAGCCCAGGGAUUGCAGCCUCUUGUUUUGCAUUUCCUGGAGUCAUGGCUAAACUCAUGGUCUCCUCAGGGGUCAAAGCAGGCCUGACUUUCAGUGUCAUCUUCAGGACACACACACGCACGCGCGCACACACACACACACACACACACACACACACACACACACACAGGAUUAUACAUGCAACUAACCAAUCACACAGAGCUGGACCAUCUAGCCUGGUAGAAGGUCUGCCGAGUUCUGCGGGUCACCAUGAACCAGGCUUGUGAGCCCUCUUAGUCAUAUGUAAAGGGCUGUGUUUGAGACCCGGUAGCCCACAAAGCUCUUUUCUGCCCAAGCCUUGGUUUUUCCGUAUGUUAGUGGGGACAGAUUGGAACUAAACAGACCUUGAGUCUUUUCAGGGUCAGUCUCAACUCUCUUAGAUGCUAGAGGGAUAUAGGCAGGGCUAGCACAGAACAGAAGCAAGAAAUAGUCAAAAUGAAUAUUUUGGACUGCAUAGACUCAGAAUGUGCUUUACUUGGGCACCCAGGGCUUCUCAGACUUCAGUUGUUUUCAUUCCACCAUUCCCUUCCUCCCCCUCCUCAUCACCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGGGCGCACAGCUCUGGGGGGAAUCAGGCACUGGGCUGUGGUGGUACCGAGGUUACCCCUGAAGUCCUCACGCCUCCCUGUGAGGUUGAUAGAUUGAAACUACCUUAUUUUGAGUAUGAGGAAAUAGAGGCACAGUGAGGUCCAGAGACCGCCCAAGAGCACACACCUAGGAAGCUGAGUGCCAGGUUUCAAAACCAGGUCUCCCUGGGCAGGGCAGGGCAUGGCUGUGUUUGAACCACUCAGGUCUCCUUUGACAUAGUUGACAGCACUAGUUACUUGAUAAUGUCUUUUUAAAAAUUAAUUUACUUAAAAAAACUUGAGUGCUAUUCUAAGCAAUGUGACAUCGUGGAUUUCUUGGGCUAGUUAUAUAUUUUAUGAUGUUCAUCAAUGUACAAUUAUGUAAAAGUUGAAUGAUCAAGUUCUGCCUAAGACCAUCUCAUGUACCAGCAGCGAGGUUAGAUUCAAAUAGAAAAAAGGGAUCUGGUCCAAGAUUUGACACGGAUUCACUGUCUGUGGGACCCCUUGCUAGGGCACUUGAUCAUCUGGGUCAUUAAAUCUGGGGGCCAGGCACAUUCUCAUUCAUUCGAGACGAGCCCAUCCUCUUCCAGAGCAUGGGGGCUUCUUGAAACCCUGUCCUUUCCAGGCACACACUGAGGUGGGGAGAGGGACCCUGGAGUCAGACCACCUGGCUUUGAAUCCCAGCUGUCUCCUCUGAGCUGUAUGGCCUAAGGCAAGUCAUUUAAGCUUCUUGUACCUCAGAUUCUCCAACUGCAAAACGGAGAUGAUAAUAGGCAGAAGCCUCGUGGGGCUGUGAGAAUCGAGUCUGCAUAUGUAAAGCACUGGGCACUGUGUCUGGAGGCUGUGAGCACCAAGCGGCUCUAAUCAUUCCCGUUUUACAAAGGAGGACAGAGAGACUAAGGAGAUAAACUCUUUCUCAUCUCUCGUUGUGUGUCAGUGCAGGGGCAGGACUAAAAGCUGGUCUGUGGUCUGCAAGCUUUAGGGGUUACAGAGUCCCCAGGAACUCCUAGGAAAUUCAGCUGGCGGCUACCUUCCACCAUCCCCAGGUUCUGAUUCGUGGGCCUGGGGUGGGACCCAGGAAUCUGCAUUUCAGUUACUUCCCAGGGGAUUCUGAUGCAGGUGGUGCGAAGACCACUUACUGAGAAGCUGCAAGCUGGGUUUGAGAGGUCCCUACCUCCUUCUUCCUUCCCCGAGCCCCACCCGCCCCCUUCUUUCCACUGGGCAACUAUGUAAACAGCAUUAUUUCUACCCUUGCACGGACAGAAAGGGGUCUGUGCUGCUGCCUCUGUUGGUGCCUCUUCAGGUCAGGGUGAUAAGAAGAGAAGGAACAAAGAGGGGAAAAAGAUCACAGCAGAGAGACAGAGUGCUCAUUUUAAGGUGGAAAUAUGCCAUUUCCUGACCACAGCGGGACUUCCCUAGGUUGUAUUAAAAAAUCCUGUACUGCCCAUGUCUGGUACAGAAGUAUGUAUAGAAUUGUAGAGAAAAUGAACACUUUGGGAUGAUUUGAAAGCAAAUUACAGAACUACCAGUUUCACCACUUUAAAACUUUUGGGGAAUGGCCAUUUAGAUAUAACCUGGUGCAGUCAGGUAACCCCAAACAGAGUUUUUAAAAGUUUCCACACCCUUCUUUGCUGGUGCCUGCCCUGCAUCAUGCUGUCGCUGUGAGGAGGGACUUGUUCCAGAUCUCUGGGGCAGCCCGAGUGACUCACCUAAAGUCACACAGCUUCCACGGAACAUUACUGGAAGCUCAGUGAGGGCCUUCUGCCUCUGAAACUUGCUCUAUUUCCCUCAAGUCCUGCUUCCUUUUGUAGGUUUAAGACAUUAGUUCCUGAGAAAUUGACUAAUCAAGAAUAUUCUGGAAAUCUUAGUUUAGCAAAAC

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Publications