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Homo sapiens (human) PSMD6 antisense RNA 2 (PSMD6-AS2) URS000075EC82_9606

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PSMD6-AS2: PSMD6-AS2 is a gene that disrupts the expression of a proteasome subunit [PMC7874462]. It is one of the key long non-coding RNAs (lncRNAs) in a network that affects more than 200 mRNAs [PMC7667426]. PSMD6-AS2 is included in a competing endogenous RNA (ceRNA) network along with other lncRNAs, mRNAs, and miRNAs [PMC7667426]. PSMD6-AS2 is differentially expressed in cancer and normal tissues, making it a potential biomarker [PMC9271611]. It has also been observed that PSMD6-AS2 expression is induced by the drug ETOP [PMC5963631]. PSMD6-AS2 is one of the 11 lncRNAs identified as independent prognostic factors in cancer patients [PMC9271611]. Additionally, it has been identified as a COPD susceptibility biomarker [PMC6981099]. In late-relapse Hodgkin lymphoma (HL) samples, PSMD6-AS2 expression was found to be up-regulated compared to early-relapse HL samples [PMC7667426]. Patients with high PSMD6-AS2 expression have been associated with longer overall survival in certain contexts [PMC9271611]. Furthermore, PSMD6-AS2 has been found to be negatively co-expressed with hsa-miR-26a-5p and positively correlated with the transcriptional levels of GINS4 [PMC9462653].

Genome locations

Gene Ontology annotations

Sequence

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UGUUUGCAAAUAAACCAUUCUGAUAAAUUAUUUUUGUUGCUUAAAAUAAGAGGAGGAACCGCUGUGUGUUAGCAAGAAUGUCCAUACCUGAUAUGAAAGAGUCAUGUUGGCUUCAGUUCCUACUGCCCUGUGGACUUCCCAUUCCCUCCUUACUUGAGUCAACCAUCCACUCAGUACUUUCCACAAAUCUAAUAAUGAGGUGCUCUCUGUAGGUAAAUCCUUUCACUAUGGCUUGUCCUCAAACCUCCCAAGAAAAGGUUCAACUGCUCAAUCUCUUAACCUUUUUAAUUCCAUUCCCUUGCAGGUAUCCCGGCCCUGCAUAACAAGAUGAUCCCAACUCAAGGAAAGGGGUUUAGCAGUGUUGGAUCUUGGCGUAUGUGGGAUUUAACCAGGCAGAAAGGCAGACAAGAGUAAGAUUCUAGGCAGAGAGAGCAAAUGCGUCGAGCAUGGGUAUGAACAUGUGAGGGAUAGAGAAUAAUUCUGCAGGAAGUUUGCUGGAUGGAAGGGCCUUAUAGGGUUAGAAAAGCUGGUGUCAGAUUGUCAAGGACUUUGAAUGUCAUGGGGCUUCUCUUCCAGGAACACAUGGGAUCAGGCUUAGAUUAACCCAAAUGUAAUUGUCAGAGCCCAGAGAUAUUUCAUGGUCCAGUCCUAGCACUGUGCAGCUGCCAAAAGUCAAAGCCAUUCAAAUCUGUACUGAAAACUGUGGAAAAGCAAAGGAGCACUUAAGUCUCUUUCCCCAUGUCUUGCAUUCUCACUCUCUUUUGCUUCAAAGAUCUGUCUUUACCUGCCCCUGUCCCCAGUCCUAACAAAAAGCACUCCCCUAAAUCAACUCUUAAGUUCCUCUCCCUUCUCACUCCUUUCUUAGUCUCCUCUUUCUGUAAGAAGUUCUUGCUCCUGUUGUUAAUGGAAGUUAAUUAAAGUAGUAUUUCACCUUGUAAGGCUGUAAUUCUUGGCACUUGUUAUCCUCAUUUUCUACAUCCAAAGACCAUGGACCAGAAUAUCUCUUAGGAGGUAAGGGAGAGUGAGGCUAUCAGCCAAAGAAAAAGUCUCCAGGGGGAAGGGGAGAAUCACUUAUAAUUUAAUACUUUGUGGAAAAAACAUCUCUGCCACCUAUGGCCCUCCAAUAACAAUGGAAGACAGAAUCAACAGGUGAGAACCUUGGGACAAAAAUAAGUUACAAAGCUGUUGUAAUCCAGGUAAGAGCUAUUAAGUUUCCAAACGAAGGCUGACUGUGAGGAUAAGUGAUACUGAUUUCAGAAAUCUUUAAAAAGUAGAACCAACAAGCCUUGAGGUCUAACUCUGUUCAACAUUAAAGGGAAGAGUGAGUCUAAGAAGACUUCAGGUUUCUAGCUUGGCCAAACCAAUUGAGCUUUAAGUGAAAUGUGCGAUAUGGUAACAGAGAAGGAAAAAGACAUAACGAUAGAUUUGAGCUGCUGGUGGGAAAUUCUGGUUUAGUGCCCAGCUGGCUGUACAGGCUGGUUGGACUUUAGGAGGGAGGUUUGAGCUGGAAAAUAAAGAUGGAGAGUUGUCUUUCAGUUUUAGAUCAUCAGUGAGGUCAUAAGGGUAGAUGGAGUUUACCUGGGAAAAUUAAGUAGCUAUUCGAUUUGGCUUAUUAUUAUGUUAAAAUAAUACUUCUCUAGUGAAGUACUUAAUAUGCCAGAUACUGUGCCAAGCAUUUUAUAUACAUCCUCUCUUUUACUAAGCCCUCAUAGGGCAGGUAUUUUGAUUCCAAUCAUACUGAUUGGAACUCCUAAGAAGGUAUCUUGCUUAAGGUCCCACAACGAAUAGGUGGCAGAUCCAGGGUAAUUCAGGUCUGUCAGAACAGUGAUUCUUAAUUUUUUCCCUCCUCAGACUCCAGGAGUCACAUGAAGUUAUGCAUCCUGUCUGACCGAGGCACAGGCACACCACAUUUUUAUAUUCCGCUUCCAGGAUAUCACAAACCUGAAGCCCAUCCUCCAUGGCCCAGAGAGAAAACCCAGGACAAAACCUUGGAGAAGACUAUUUUCAUGAAGACAAAUGGAGAAGGAGCAGUAGAGUAAAAAGAGAGCAAAUCCAGCUGCCUGUACAAUCCAUGCCACCGAAUGCCGUAAGUGAGACGUAAAAGUUACGAUACUGAAGAGACGUAACCUGACCAAGGCCACAGAGCUGGAAAAAGAAGCAAAGCCAAGCCGUUUUUCUCAUGCACUGCUCACAACAAGCCCCUCCUUCCACUGACUCAUGAAAAACACACUCAUAAUGCCCAGCCCGCACCCUAAUGAACAGCCCUCUUAAGAGUGGUCAUCAGACUUCAAUUUCACAGACUAGAAUUGAGAAAUGGAACAAAACCUUGGGAUACCAGCCUUCCAUUUUGGUAGGGAUCAUUUAAAAAAUGGUAGGGAUCAUUUAAAAAAUGUGUUGGUGUCUGAAACUUACUUUGAAGUGGUUAAAAAACAUAAAAUGUAUAGAUUGUAACAAGCAAAUAUGUUAAAAUGUACUGUACAAUUCUUUCUUUACAAUUUUAUGGAUGUUCGAAAUUUAAAAAAUACUAGAAAGAGAAUGGUCUUAUUUAAAAAAAA

Taxonomic tree

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Publications