v24

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Homo sapiens (human) long intergenic non-protein coding RNA 513 (LINC00513) URS000075E2F6_9606

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LINC00513: LINC00513 is a long non-coding RNA (lncRNA) that is induced in response to type I interferon (IFN) treatment and is not limited to specific cell types [PMC6305415]. MIAT has been shown to participate in negative feedback loops of the VEGF and TGFb1 pathways, by inhibiting microRNAs miR-150-5p and miR-24, respectively, resulting in the regulation of endothelial cell proliferation, migration, and apoptosis [61–63]. A novel lncRNA, termed LINC00513, was recently associated with increased susceptibility to systemic lupus erythematosus (SLE) [PMC9985893]. Two variants located in the promoter region of the lncRNA, rs205764 and rs547311, were demonstrated to upregulate its expression and increase STAT1 and STAT2 phosphorylation with further activation of the IFN pathway [PMC7309355]. However, there is currently no evidence linking LINC00513 with multiple sclerosis (MS) according to the most recent MS genetic map [PMC9985893].

Genome locations

Gene Ontology annotations

Sequence

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AAAACUCCCUUCUGUUCAAAAACCCUAUGAUCCAUGCACCCUCUGUCUAAUCCUCUGCGAUGGGGCCAGUCUGCAGAUCCGUCUGGGCGGGCUGCGGUAGCAUUCUCCACCUGCCAACACUCAGUUGCUGGUGAGUAACCAGCAUACGGACUCUCACUUCCUAGAUGACGCCUUGCUGUGUUGCCCAGGGUGGUCUCUAAUUCCUGGCCUUUAGCAAUUCUCCCGCCUUGGCCUCCUAAAGCACUGGGGUUACAGGCAUGAACCACUGUGCCCAGCCUGCAUGAUGUAAUCUCCAAAUUGAGGGCAGGAGAGAGAGUGGUCUCACAACGGAAGGGCACCAGCCACUGAGAAGUCCUAAGGCCGUGUUUGAGUUCUGGCUCAUCUUUUUUGCUAAUUUGCUCUUAUGCAUAUCACCCAACCUCGCUAAGCCAGUUUCAUCAUCAGCGAGAACAGCACACUGACAUGCAGGGCCAGCUCAGGCGCUACCACAAGCUACACAUCCGUCCAUUCGUUUAAUCUUCACAGCAGCCCUGGAGGUCACCCAGGCAUGGAAUGCACAGCUCUGCCAGACAGAAAGCGCUUUGGAUGCCUGAGAAACAACAGCUUGUCCGGGCUACUGAUGCGAAGAGAGGCCAUGGUUUCCUUUUUCUCUGCUCUGAAUGGCAGCCUUGACGUCACAACAGCUAGGAACCACUGGAGGGACAAAUAACAAGGCGCAAGCCAGAAGCGCCCUGCUCUGUCGCAGGGGCAGGGCCAUUUUCAUCCAGUUCUGAUGUCUUCUGUGGCCGCUGCGAGUCGGCGGGAGUAGAGACAAAUGACUGGAGCUUUAGGCGUAAAGGCGGUCUCUCUCUAGGCUGAUCAAACAGCCCUUUGCCCAGUGCUAAUUGCCUUCACGGAACCUGGAUAAACUACAGUUCCCGAAUUAAACUUGUUUCUGAUGAACUAGAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications