v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) HOXA distal transcript antisense RNA (HOTTIP) URS000075E1E7_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

HOTTIP: HOTTIP is a long non-coding RNA (lncRNA) that has been found to play a role in various biological processes and diseases. In the context of osteoarthritis (OA), the expression of HOTTIP was upregulated in OA cartilage compared to normal cartilage, while the expression of miR-455-3p was downregulated [PMC6716540]. HOTTIP was found to inhibit chondrogenic differentiation of human mesenchymal stem cells (hMSCs) by enhancing the expression of CCL3 and absorbing miR-455-3p, leading to cartilage degradation [PMC6716540]. In addition, HOTTIP has been implicated in gestational diabetes mellitus (GDM), where its overexpression was shown to alleviate insulin resistance and hepatic gluconeogenesis by modulating the miR-423-5p/WNT7A axis [PMC9275933]. Furthermore, HOTTIP has been associated with ovarian cancer, where it enhances interleukin 6 (IL-6) expression and promotes immune escape by upregulating programmed death-ligand 1 (PD-L1) in neutrophils [PMC7576285]. Overall, HOTTIP is a versatile lncRNA that can regulate gene expression and contribute to various biological processes and diseases.

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
CCCUUCCUUUAUCCCAGUGGGGCCCAGACCCGCGCAACCAGGCGGGGAGGGGAGGUGGGCGCGCGAUUGGGUUGCGAUCUGGAGCAGUGGGGACAGGUCAGGAACCGGCGCGUAUUUCUGCAGUGAGACCACAGGACGGACAUCGGCGCCUUCGGCUUCGAUGGAGUUGCGAUUUUGCUCUUUCCAGGGAAACAGUGGCAGGGUGUUUGCUGCUUAUCGGUUCCUGCGGAUAUGCCUGGGUCCCAGGACAUUCCACUGGAGGCUUGGACUGCAUUUAGGAGCCCCUAUCCCUUCCCUGUCCACACUGUUAGUGAGCAAUUUCAUAUGUUUGCAUUUAGACCCAUAGACUCAGAACGACUCAUCACACACACACACAGUGUACACUGACACACUCACAUUCGCACACUUAGGUAUACAGCCUGAUCCUUGCUCUGACCUGGUAACAACGCUUCCUCCUCCAGAGACUUUGAGAUAGAGCGAGCGAUCCCUGUGCACCAUUCAUCCAUGCUCCCACCUCGCCAGUAUGGCUGGCUUAGUUCUGGAAGGGGCUUAAGAGGAACAAGCCCCAGCUGUGCUUCUGGCUGGGACUUAAACCCCCCUUCUGGGCCCUAAAGCCACGCUUCUUUGUGGACCGGACCUGACUCUCCAGGAAUCUGGGAACCCGCUAUUUCACUCUAUUUUGGGACAAGAAAAAGGGGCUCUUUGGGGCCACUUCCUGCCUUCCCCUCAAGUAGGAUCUCCAGCCUGCAGAGGGUGCCUAGUCCUUCUUUGCCCAAGAACCAGUCCAAGAAGCCUUUCCUCUGUGCCUGGGAAAUGCAACCUUUUCUUGGGAGCAUGGUAGGGUGUUGGUGCUGAAGAACCAAGCAGCGACCCGUCUUGUAGCUGCCAUGUUUUGUCGAGGGGUUCUGGGGGUCCUGCUGCUUUAGAGCCACAUACUUCCACUUCCUGAUUCACUACUGUGAGCUGGUCAGAUGCCUAGAAGAGGAACAAGCGUUCAAAGUGAAAGUGGGCACAUUACCGGAAUAGUGCUGGGGAGAGUGCUGGAUUCUUUUCCACCCCAGGCGGACUGGUGAGAAGCCAGGCUUGGACCUGUCCUCUGCUCCUAGCUUGCACACUCAGCCCUAAACUCAGAGCAGCACGCAUACCACCCCUCACACACACCCCACCAUCUGCUGUCUAAGGCCCCUGGGCUUCCUGCAGGAUCCAGACCAAUGUGGCUGGGCUUGGGCUUUUAUCUGUCCUGAUCCUGGAUUUGUCCUGACCAAUGUAAGUGUCGCCCAAUAAAACCUUCUAUGACCCCCACACCAGCCACCCCCCCACCAAGUGUGCCCUUUCCUUCUUGACUUUUUAGCAGUUCUGGGUAAAUAUUGAUUUGCCCCCAGUUUACCUUCUCCCUGACUGGCCAUUUGCAGACUCAGGAACUAGCCUCUGUAGGGACUUGAUUUUUCUGUUACUUUCUGGCCGUUUCACCACCCCCCUUCCUCCCUCCAAGUGGCAUUGUAAAACUCACAGUGACAAAGAGACAGAGUAGGGUUCUAGGCCCCUGUUCCUGGGGACUUGAAGGCGGUUUUACAUACUGGUCAGACACGGCUGGAGGCCAAGGUCAAGUUGAAAGUUGCAGUCCAGCCAGCAUGAGAACUGCCAUGCGAGCGUAGAGACACAGGCAGCAGCAAAAGGCCCAUUGCCCACAUCCCCUCACUCUUAAUUUUCUCUCUCUUUUUAAAAUUCUCGCCUCUGACUCUGUUCGGCUGCCCAGAAUUUUUUGGUGCCUUCGUGGGGUUUUUGGGGCGGUGUUUACCGACUCUUCUCUGCCUCCGCCCUGCUCAGCCAGGGCUUUGAGCCUCUUCGGUUUUCCGGCCAGACCCGGAAAAACGAAAACACAGCUUGGGGAGCCCCCACUAGCCGGCGCCUGUGCCAGCUCACCUCUGGCCAUGGCGCAGCUGCCGGUGCACACGGCGGCCAAGGCCAGCUCCACAUUCUUCCCUCCCCCUCCCACUUCACCGUAGCCCCGAACCCUGCGCGCAGAGAAAGGGUCUCAGCUCCACAGACGACUGGGUCCCUCCUCACCAAAAAUGGUGAGACAAGAUUUCAUCUGUCGGCCGAGGAGCCACAAGCAGGUACCACAAAGCCACUAGUGCACAGGGACUCAGAAAAGACGGCAGGAGCCCAAGGAAAACUCCAAUUUGAGUACAGCCCUGCCUUGUUUCCCCCAGAGAGUCCCUGAGCAAGGAGACCUCCACCCCACACACACCAUUUCAGAACAACCAGGUUCCAGACUCCCAUGAGGAGCAUCUCCCACUGCAGAGCCUUGGCCAGCCGCGCCCGGACUCCUCAGAGCUGGCGCAAACUCCGUCCUCCAAAACUCGGCUCUGGGAGGCCUAAGUGACUCCGAAGCCGGCGGCAGCCGCGGCAGCGGCCGUGGUGGUGGAAGAGCUCUUUUCCCCGACAGUGCCACUGAUCGCUCUUCACUGGAGCUGGAAACAGCCUUCGCGGAAAGGACCGGAGCAUGCGUUAGAAGCAGAGGGAGCUUGGUGAAGGGCUCGGCUGGAAGGAGGAAACGCCUUCUCGCAGUGCGCGGCCAGCCCGCGGGGGACACCGGCUUGCUGGACUGCAGGGGCCCGUGCCACCCAGGAAGUGACCUGCGGGUCACUCAGCCGGGGCGCUGGGCGAGCGCGGGACGGCCCGGAGAAUUCCGUGCGGCUGCGACGGGAAAAGGACGAGGGGUCUCUGUACCCGACGCUGCCACUGGCCCAAAGGAAUUUUACCCGCGAGCGCCCACCCCACCCUAGCUUGAUGCUUACGCCCGCAACAAAACAGGAAACCAGGACUGGGCAGUGCAUUCUUUAAGUCAACAAAUACACUGAAGACUUCGAGCGUUUGAAGGAAGGAGGGGGUUUGCACGUAAGCCUGGCCCCGCCGGGCUCGGCUUUCUCGCUGAGAAAGCGGCGCAGGCAGCCAGGCGGCCUGGGCCCGCGGGGGUCCAUCUCGCCCUAGACUCCUAAGAACUCCCACGGCCCUGUUCCCAGCUGCGAAUUCUUAAUGCACAACGCGACGGAGGGAAGGAAAUUCACCAGCGCAGCGACGAGGAAGGGGAACUCAGGACCCCUUCAAGUACACACUGAGGUGUGAUCAGAGUUUUAUGGGCACUUUAUAUGCUGUAAUCAUAACGAUGUGUGUGCCUUGAUAUGCACGCAUAUUCACGCAUCAAACGUGCAUACACACACAGAGUGAAUGUGCGCAUCCAAUGUCAUGUGGGUGAAAUACAAGCAUCAUACCCAGCCCUACGAAAAAAAAAUUCACCCUGUCGGACCAGGCUGGUGACAUACUUCGCUGGCGCAUCUCCUUACUCACUCUUACUUUUCCGACCCCUCACCAUUCCCUCUCCUGUGGCUUGGUAAAUACACCUGCCCUCCGUGGAAGGUGAGUCCUGGACUGGCGUUGCCAGGUUCGCAUGUCCUCCCCAGAACCUCCGUCUGGCUCCAGGGACUCUCACUGAGCGGGUCUAGAGCACCCAGCACUUUUCAAGGAACAGCCGCGGUUCCUUUGUCCCGCGGCUCCAGCCCCGUUCGGCCCAGCUCUCAGGGAAACGAAGCGCUCAGUAAGAACUUUUGAUAUUAGUUUGUAUGGGUAUUUACACUCUGGUGAGGGGAGCUGAGUACGGAAGUUCCAUUAAUCAUACUCCAACCUUGGGUUUAGAUAUUCAGUUUAUGGGUUGGGAGAGGGAGUUUGCCGGAAAGAAAGCAUCAAGGUUGGCCGCUGACUCCAGAGAAAUGAAAAGGGAGCAAGGUCGUUUUCUGUUUCUGGAAAUCAAGAAUUAGGAAUGGGCAACUACAGGUGCUAACCAACAGACCACUUUUUUGUUUUUUGGUAGCCCUUUGGCAGGGAUAGUUUUUCCACCUUUGCCCGAUACAAUUUAAAAAAAAAAAUCCUUUUAUUAUGGAAUUUGUCAAACACACACACAAGCAUAACAAACCCCUAGGUACCCAUCUCCAAGUUUUGACCCCUAUUAUAAUUUCAUCUUCAGUGUUUUAUUAUCCACUUCCUCUCUCUCUAUCUUUAGUAUUUUAAAGUAAAUCCCAGAUAGCAUCACAUCAUUUCACCCCCACCAUAGGAUUUCAAAGAUCUGUUAUAUUUCAAGAUUGAGUAAAAGGGCUUGAAAUUGGGUUAUUGCAAUGAAACUCUAGAAAAAGCUUGAGGGUUCACCCAGGAGUAAGCUGGACAAAAAAGGGGUUUGAGGGGUGGACCCAUCUUGCCUAAAAAUCUUGUCUCAUCUUUCUAAAAAUUACAUAUGAAAGAGGAAGAUUUAUGUUACUUUUUUAUAUGAGAGAAUCGUCCUUUAAUAGAAAAUUUCUAUUGCUGCAUCAGAAUUAUGGAGGAACACAAAAAACAUACCUCAGUCCUUAGUGUGUCCUAAAUUAACACAUAUUCACUUAUUAGUGGGUAAAUGACUAUAUUUCAUUUCAGCACAACUUCUCCCCUGGUAGAAACACAAAAGAAAUUUCUAAUGAUUAAACUAGGAAAGUUUGCACUGAAUUGAUGGCUUAUCAGAGCAACCGCAGUUUUCAGGAAGAAAUUCAAUGCCAUGCGUUGAAAAUAUCCCCCUAGCAAUAAGGGAUUAUUUUUAAAAAAGAAUGAAUAAAGAUGUUCUGGUUUCUUUUGUUUUAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications