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Homo sapiens (human) lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interacting (LERFS) URS000075DE51_9606

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LERFS: The lncRNA lowly expressed in rheumatoid fibroblast-like synoviocytes (LERFS) is downregulated in synovial tissues and cells of rheumatoid arthritis (RA) patients compared to healthy controls [PMC6909907]. LERFS negatively regulates fibroblast-like synoviocyte (FLS) aggression and proliferation, and its downregulated expression contributes to synovial proliferation and joint destruction in RA [PMC6909907]. LERFS interacts with heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) to suppress FLS migration, invasion, and proliferation [PMC6909907]. LERFS is also downregulated in the post-mortem frontal medial cortex of subjects with bipolar disorder [PMC7549354]. In vitro and in vivo experiments have shown that LERFS negatively regulates RA FLS migration, invasion, and proliferation through its interaction with hnRNPQ [PMC9395482]. Microarray analysis has revealed significant downregulation of LERFS in RA FLSs compared to healthy controls [PMC9395482]. Other lncRNAs have also been found to be dysregulated in FLSs from RA patients [PMC8858953]. LERFS suppresses the expression of small GTPase proteins RhoA, Rac1, and CDC42 through its interaction with hnRNP Q [PMC7176443]. The decreased expression of LERFS negatively regulates the proliferation, migration, and invasion of RA FLSs [PMC7176443]. The decreased expression of LERFS contributes to synovial aggression and joint destruction in RA by increasing rheumatoid synovial aggression [PMC8718819][PMC7549350][PMC8974142][ PMC6627692][ PMC7388364][ PMC7994855][ PMC8479066].\

Genome locations

Gene Ontology annotations

Sequence

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AGUGAGGUCGGCGCCCGCCAGUAACAAACAUGGCUCCCUGAAGCCGCUCAGGCUCAAGAGCAACAUGGAGGUCUGCACUUAAUCGCUCCUCUCCGGGGGCGGCCAUACCGAGGAGGCGUCUCUUCCGUGCAGGCAGGCUCUCCUGGGGACCUCAGAGAUUCUCUCCAGCGGCAGCGGAAAACGGACAAUGGGUGGAUUCGGGUCCAGAUUCUGGUAGGAGGGAGUUUGGGAUCGAGAUCUGGAAAAAAGCACUAGACUGGAAGAGGACGCGAUGGAGUCGGAGCCGCUGGCGGGGACAAAAACCAGAGGCCGGGGAAGGCGCCGGUGGGAGGCAAGGCACGGAUGGACUUUACCUGCGCACGCGUCGCAGCCAUCUCCGCGCACAGUGGUGGCCACCGCGACUGGUGCUGAAGUGUUGGCGCGUGCCGGGCGCUCCGCUGGGACCCGGGUUGCUGGCCCUGAGUCUCAGCUUUCUCAUCUGUACGGUUGGGACAAGUACAGUAACCCUCGCCCGUCAAGACGGGCCAGGGCUGUGGCGAGGGUCCACGCCUUAGAGCAGGCAGGAGUAGGGCUGAUUGGAGCCAUUGUACAGUGUCGGGAACAUACCAGGACACUGAGAAUAGUGUCAUGUCAUAAGGACCCAGAGCAGAUGGACCCUGCUGUGAUGCACAAAGAAAUCAAUGGAGCCUAUUCUUCCAAAUAAUCCUUAAAUAUUACUUAUCUCAACUGAGAUUUUGGUGAAAAUUUAGCUUUAGAGCUUUUAUUGACCUGCCAAUGACCUGAAGUUAAGAUUAUUCUUUUCUACUGAAUGAAGACAAACUACCUUAUAAAAAUUAACCCAGAAGGCUGUAGAGGGAUGAAAUGGGAUUUUGUUGGCACCAAGACCUGAUUGCUUUGCCAGUUACCCUCACCCCUGGCUCACAAGGAAAGUGUAUGGAGGAGAUUCUCGAGGAACCACAUGAGUUUUAAUAUCAUAAGCUUCUGCCCUGAAUUGAAAGAUAGCAGCAUUUUAAUCAUCUCUUCCAUUAAACCAAGAUUACACAAAAGCGUUUGAGGACACUGAGGACUGGGACUUCUAAUUUUGCUUCAGAAACCAGUACUCAAAAUGUCUGGUUUGGAGGAGCUGGGCUGCUUGGAUCAGAGGUUCCAUGGUCUGAACUACUCCACUCUGGUGAAGGUUUCUUCCCCAAAGCCACUCCUCAAGCUGACUUAUAUUGUACCUGAGUUGCAUGCCUGUGCUCCAAGAGCAGACGUCCUUCCGCAGGAGCAGGUCAUUAAGAGUCACUGCGUUGAUCAUGUAGAAGAGCUGUUUGAAUACCUGCAGGAUGAUCUCAGGGUCCAAGCCCUGGUCACACAUGACUGUAUGAAAGGCAUUCAUCUGGCGGAUGAUAGCUUCCAGGCGGUAUGAGUUAUCCCCAUCUGCCAUGCUGGAGGAGUGCUUCUGGGAG

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Publications