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Homo sapiens (human) long intergenic non-protein coding RNA 2076 (LINC02076) URS000075DCEC_9606

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LINC02076: LINC02076 is a long non-coding RNA (lncRNA) that has been studied in the context of neuroblastoma (NB) prognosis. In a study, four lncRNAs, including LINC02076, were identified as having the best prognostic value for progression-free survival (PFS) in NB patients [PMC9753905]. Among these four lncRNAs, LINC02076 was found to be a risk factor for PFS [PMC9753905]. The expression levels of AL356599.1, AC022075.1, AC020928.1, and LINC02076 were found to be higher in NB cell lines compared to HEK293 cells [PMC9753905]. High expression of AL356599.1 and AC022075.1 was associated with relatively good PFS, while high expression of AC020928.1 and LINC02076 was associated with relatively poor PFS [PMC9753905]. The prognostic role of these lncRNAs was found to be independent of MYCN amplification status [PMC9753905]. LINC02076 was significantly positively correlated with the autophagy-related gene MAP2K7 [PMC9753905]. The expression levels of AL356599.1, AC022075.1, AC020928.1, and LINC02076 were significantly increased in NB cells after the addition of an mTOR inhibitor [PMC9753905]. In addition to NB, the expression levels of these lncRNAs have been found to exhibit significant differences between normal and tumor tissues in various types of cancer [PMC9753905]. However, specific roles for AC020928.1 (updated as LOC728485) and LINC02076 in cancers including NB have not been reported in the literature [PMC9753905].

Genome locations

Gene Ontology annotations

Sequence

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AACGUCUUCCCACCUUUUUCUCCCCUCUCCGUCUUCUCCCCUCCUUCUUCCCCACUGCGGUCUUCCCGCAUCCUCUUCUGCCGUCUCCCUACUGUCUUCUUCCCGCACCUUCUUCUCCCCCGCAGUUUUUUUUUCCCCUUCCCCACCGUUUUCUUCCCCUCAGUCUCUCCCAUUCCUCGCAGCACGGGUUCCUGUGGCGGCAGCUUUUCCUUCCAUCUCCUUCUCUCCACCCGCUGGCUUCCAGUCUCCACCUUCCCGCCUAUUCCCCCAGCAGCGUCUUCCCGCCGCUCCCUCUUCUCCCCUCCCCCUCCUCACCGUCUUCUCCCGGCCUAUUACCGCCAACCGUUUUCUUCCUCAUCCCGCACCCUUUUCUUCCCAUGUCUGCCUUAGUCUUCUUCCCACCCUCUUCUCCUCUCCCCAUCGCCUUCUUCCCACCCUCUUCUCCUCUCCCCAUCGCCUUCUUCCCACCCUCUUCUCCUCUCCCAAUCGUCUUCUUUCCCAGCCUCUUCUCCAUUUUCUUGCCGCCUCCAUAUCCCCACCUUCUUCUCGCAGCAGCGUCUUCCUGCCGCGCUUUUCUCUCCCCUCACCAUCUUCUCUUCCUCUUCCCCACCGUCCUCUCCCCACGCCCUCUUCUCCUCACUGUCUUCUCCCCGCGCCUUCCCCACAACCGUUUUCUCCCCCGUUUUCUUCCCCUCACACCGUUUUCUUCCCAUGUCCUCCCACCGUCUCGCAGCAGCGUCUGUCAGUCGCAAUCUUCUUCCCACUUUCUUCUCUCCCCCUCCCAUCGUCUUUUUUCCCCAGCCUCUUAUUCUCCGCCAUCUUCUUCCCCUCCCCACCUUCUCGCAGCAGCGACUUCCUGCCGCGUUUUUCUCUCCCCGCACCCUCUUCUCCCCUCUUCCACUCCCCACCGUCUUCGCCCCCGAUCGUCUUCUUGCCCACCCCCUUCUCGCGCUCUCCAACUGCCUUUCACCUAGAAGCGCUCCACGCGUGCGCCCGCCUGUGUCCCUGCGCCUGGUGUGUCUGUGCGCCCAGCCAGCCCCAUGAGCUGGGCCCCUGAGCUCCGCCCCAACAGCCAACAGGAGACCCAGGAGAGUCGCUGCCAGGGCCAUCACGGCUGCCGCCGCCCCCGCCCCCGCCGCUACCUCAGAACUGAACAGUGUUGGCUGCGGGCGAAAGGCAGUGGGGCCCGGAAGACUGCGGGGAGAGGGGGAGGAGGGGACGGAGAGGGUGGGAAAGACCUUGGAAAGUGGGAUGGGGAGAAAGGUGGGGAAGAAGACAGUGGGGAGAAAGUGCAGGGAGAAGACAGUGUGGUAGAGAAGACAGUGGAGGAAAACGGUGAGGAGAAAGGAGGGUGGAAAAGAAGACGAUGAGGACAAGGCCGGGCGCGGUGGCUCACGCCUGUAAUCCCAGCACUUUGGGAGGCUGAUGCGGGCGGAUCACAAGGUCAGGAGUUCGAGACCUGCCUGACCAACAUGCUGAAACCCAGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCGUGAUGGCGAGCGCCUGUAAUCCAGCUACUCCAGCGCCUGAGGCAGGAGAAUCGCUUGAACCCCGGAGGCGGAGGUUGCAGUGAGCUGAGAACUCACCAUUGCACUCCAGCCUGGAUGACAGAGAAGGUCAUGGGAACAUACAGAGACCUACAGGGAAGACGGCCAUGGGACAAGGGAGGCAGAGUCUGGAGUUACGCUGCCUACAGUCACGGAAUGCCAAGGACAGCUGGAAACCACCAGAAGCUAAGAAGGAGAUUUUACCUGAAAGCCUCUCAAAGAAAUCAAUCAUACUCACACCUCCUUUUUGAAUUUCUGGCCUCGUGAAUGGUGAAAAAAUAAAUUUCUGUCGUCUUAAGCCCCA

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Publications