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Homo sapiens (human) nuclear paraspeckle assembly transcript 1 (NEAT1) URS000075DAEC_9606

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NEAT1: NEAT1 is a long non-coding RNA (lncRNA) that has been shown to play a critical role in various biological processes and diseases. In a study investigating the protective effects of melatonin on hippocampal neurons, it was found that melatonin upregulated the expression of NEAT1 and 1810026B05Rik, but had no significant effect on SNHG12 [PMC9657978]. The knockdown of NEAT1 inhibited the protective action of melatonin, suggesting that NEAT1 is critical for melatonin's resistance to oxidative injury [PMC9657978]. Additionally, the knockdown of NEAT1 hindered the protective effect of melatonin by inhibiting the protein level of Slc38a2 [PMC9657978]. In another study, it was found that shikonin suppressed cell growth and induced apoptotic death in NEAT1 knockdown cells, indicating that NEAT1 is involved in shikonin's effects on cell survival [PMC7140387]. Furthermore, NEAT1 has been implicated in bone metastasis and cancer cell metastasis through m6A modification-dependent mechanisms [PMC10033960] [PMC8585929] [PMC9953056]. Additionally, NEAT1 has been shown to promote ferroptosis in hepatocellular carcinoma cells and regulate the expression of ferroptosis-related genes [PMC9433379] [PMC9480065]. Overall, these studies highlight the diverse roles and mechanisms by which NEAT1 contributes to various biological processes and diseases.

mRNA interactions 5 total

Genome locations

Gene Ontology annotations

Sequence

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GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAGGAAGUGGCUAGCUCAGGGCUUCAGGGGACAGACAGGGAGAGAUGACUGAGUUAGAUGAGACGAGGGGGCGGGCUGGGGGUGCGAGAAGGAAGCUUGGCAAGGAGACUAGGUCUAGGGGGACCACAGUGGGGCAGGCUGCAUGGAAAAUAUCCGCAGGGUCCCCCAGGCAGAACAGCCACGCUCCAGGCCAGGCUGUCCCUACUGCCUGGUGGAGGGGGAACUUGACCUCUGGGAGGGCGCCGCUCUUGCAUAGCUGAGCGAGCCCGGGUGCGCUGGUCUGUGUGGAAGGAGGAAGGCAGGGAGAGGUAGAAGGGGUGGAGGAGUCAGGAGGAAUAGGCCGCAGCAGCCCUGGAAAUGAUCAGGAAGGCAGGCAGUGGGUGCAGGGCUGCAGGAGGGCCGGGAGGGCUAAUCUUCAACUUGUCCAUGCCAGCAGCCCCUUUUUUUCCAGACCAAGGGCUGUGAACCCGCCUGGGGAUGAGGCCUGGUCUUGUGGAACUGAACUUAGCUCGACGGGGCUGACCGCUCUGGCCCAGGGUGGUAUGUAAUUUUCGCUCGGCCUGGGACGGGGCCCAGGCCGGGCCCAGCCUGGUGGAGCGUCCAGGUCUGGGUGCGAAGCCAGGCCCCUGGGCGGAGGUGAGGGGUGGUCUGAGGAGUGAUGUGGAGUUAAGGCGCCAUCCUCACCGGUGACUGGUGCGGCACCUAGCAUGUUUGACAGGCGGGGACUGCGAGGCACGCUGCUCGGGUGUUGGGGACAACAUUGACCAACGCUUUAUUUUCCAGGUGGCAGUGCUCCUUUUGGACUUUUCUCUAGGUUUGGCGCUAAACUCUUCUUGUGAGCUCACUCCACCCCUUCUUCCUCCCUUUAACUUAUCCAUUCACUUAAAACAUUACCUGGUCAUCUGGUAAGCCCGGGACAGUAAGCCGAGUGGCUGUUGGAGUCGGUAUUGUUGGUAAUGGUGGAGGAAGAGAGGCCUUCCCGCUGAGGCUGGGGUGGGGCGGAUCGGUGUUGCUUGCCUGCAGAGAGGGUGGGGAGUGAAUGUGCACCCUUGGGUGGGCCUGCAGCCAUCCAGCUGAAAGUUACAAAAAUGCUUCAUGGACCGUGGUUUGUUACUAUAGUGUUCCUCAUGGCGAGCAGAUGGAACCGGGAGACAUGGAGUCCCUGGCCAGUGUGAGUCCUAGCAUUGCAGGAGGGGAGACCCUGGAGGAGAGAGCCCGCCUCAAUUGAUGCCUGCAGAUUGAAUUUCCAGAGGCUUAGGAGGAGGAAGUUCUCCAAUGUUCUGUUUCCAGGCCUUGCUCAGGAAGCCCUGUAUUCAGGAGGCUACCAUUUAAAGUUUGCAGAUGAGCUUAUGGGGGGCAAUCUUAAAAAGUCCACAGCAGAUGCAUCCGGCUCGAGGGGCCAUCAGCUUUGAAUAAAUGCUUGUUCCAGAGCCCAUGAAUGCCAGCAGGCACCCCUCCUUUCCUGGGGUAAAGGUUUUCAGAUGCUGCAUCUUCUAAAUUGAGCCUCCGGUCAUACUAGUUUUGUGCUUGGAACCUUGCUUCAAGAAGAUCCCUAAGCUGUAGAACAUUUUAACGUUGAUGCCACAACGCAGAUUGAUGCCUUGUAGAUGGAGCUUGCAGAUGGAGCCCCGUGACCUCUCACCUACCCACCUGUUUGCCUGCCUUCUUGUGCGUUUCUCGGAGAAGUUCUUAGCCUGAUGAAAUAACUUGGGGCGUUGAAGAGCUGUUUAAUUUUAAAUGCCUUAGACUGGGGAUAUAUUAGAGGAAGCAGAUUGUCAAAUUAAGGGUGUCAUUGUGUUGUGCUAAACGCUGGGAGGGUACAAGUUGGUCAUUCCUAAAUCUGUGUGUGAGAAAUGGCAGGUCUAGUUUGGGCAUUGUGAUUGCAUUGCAGAUUACUAGGAGAAGGGAAUGGUGGGUACACCGGUAGUGCUCUUUUGUUCUUGCUUCGUUUUUUUAAACUUGAACUUUACUUCGUUAGAUUUCAUAAUACUUUCUUGGCAUUCUAGUAAGAGGACCCUGAGGUGGGAGUUGUGGGGGACGGGGAGAAGGGGACAGCUUGGCACCGGUCCCGUGGGCGUUGCAGUGUGGGGGAUGGGGGUAUGCAGCUUGGCACUGGUACUGGGAGGGAUGAGGGUGAAGAAGGGGAGAGGGUUGGUUAGAGAUACAGUGUGGGUGGUGGGGGUGGUAGGAAAUGCAGGUUGAAGGGAAUUCUCUGGGGCUUUGGGGAAUUUAGUGCGUGGGUGAGCCAAGAAAAUACUAAUUAAUAAUAGUAAGUUGUUAGUGUUGGUUAAGUUGUUGCUUGGAAGUGAGAAGUUGCUUAGAAACUUUCCAAAGUGCUUAGAACUUUAAGUGCAAACAGACAAACUAACAAACAAAAAUUGUUUUGCUUUGCUACAAGGUGGGGAAGACUGAAGAAGUGUUAACUGAAAACAGGUGACACAGAGUCACCAGUUUUCCGAGAACCAAAGGGAGGGGUGUGUGAUGCCAUCUCACAGGCAGGGGAAAUGUCUUUACCAGCUUCCUCCUGGUGGCCAAGACAGCCUGUUUCAGAGGGUUGUUUUGUUUGGGGUGUGGGUGUUAUCAAGUGAAUUAGUCACUUGAAAGAUGGGCGUCAGACUUGCAUACGCAGCAGAUCAGCAUCCUUCGCUGCCCCUUAGCAACUUAGGUGGUUGAUUUGAAACUGUGAAGGUGUGAUUUUUUCAGGAGCUGGAAGUCUUAGAAAAGCCUUGUAAAUGCCUAUAUUGUGGGCUUUUAACGUAUUUAAGGGACCACUUAAGACGAGAUUAGAUGGGCUCUUCUGGAUUUGUUCCUCAUUUGUCACAGGUGUCUUGUGAUUGAAAAUCAUGAGCGAAGUGAAAUUGCAUUGAAUUUCAAGGGAAUUUAGUAUGUAAAUCGUGCCUUAGAAACACAUCUGUUGUCUUUUCUGUGUUUGGUCGAUAUUAAUAAUGGCAAAAUUUUUGCCUAUCUAGUAUCUUCAAAUUGUAGUCUUUGUAACAACCAAAUAACCUUUUGUGGUCACUGUAAAAUUAAUAUUUGGUAGACAGAAUCCAUGUACCUUUGCUAAGGUUAGAAUGAAUAAUUUAUUGUAUUUUUAAUUUGAAUGUUUGUGCUUUUUAAAUGAGCCAAGACUAGAGGGGAAACUAUCACCUAAAAUCAGUUUGGAAAACAAGACCUAAAAAGGGAAGGGGAUGGGGAUUGUGGGGAGAGAGUGGGCGAGGUGCCUUUACUACAUGUGUGAUCUGAAAACCCUGCUUGGUUCUGAGCUGCGUCUAUUGAAUUGGUAAAGUAAUACCAAUGGCUUUUUAUCAUUUCCUUCUUCCCUUUAAGUUUCACUUGAAAUUUUAAAAAUCAUGGUUAUUUUUAUCGUUGGGAUCUUUCUGUCUUCUGGGUUCCAUUUUUUAAAUGUUUAAAAAUAUGUUGACAUGGUAGUUCAGUUCUUAACCAAUGACUUGGGGAUGAUGCAAACAAUUACUGUCGUUGGGAUUUAGAGUGUAUUAGUCACGCAUGUAUGGGGAAGUAGUCUCGGGUAUGCUGUUGUGAAAUUGAAACUGUAAAAGUAGAUGGUUGAAAGUACUGGUAUGUUGCUCUGUAUGGUAAGAACUAAUUCUGUUACGUCAUGUACAUAAUUACUAAUCACUUUUCUUCCCCUUUACAGCACAAAUAAAGUUUGAGUUCUAAACUCAUUAGAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications