v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) RASSF8 antisense RNA 1 (RASSF8-AS1) URS000075DAC8_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

RASSF8-AS1: RASSF8-AS1 is a long non-coding RNA (lncRNA) that plays a role in regulating autophagy in human aortic vascular smooth muscle cells (HA-VSMCs) [PMC9951013]. Knockdown of RASSF8-AS1 in HA-VSMCs treated with oxidized low-density lipoprotein (ox-LDL) resulted in decreased protein expression of ATG7 and Beclin-1, decreased ratio of LC3 II and LC3 I, and increased expression of P62 [PMC9951013]. These effects indicate that RASSF8-AS1 knockdown promotes autophagy in HA-VSMCs induced by ox-LDL by regulating ATG7 [PMC9951013]. On the other hand, overexpression of RASSF8-AS1 led to a significant reduction in the colony formation ability of cells compared to those transfected with empty vectors [PMC7551431]. This finding suggests that RASSF8-AS1 may have a suppressive effect on cell proliferation [PMC7551431]. Overall, these results highlight the role of RASSF8-AS1 in regulating autophagy and cell proliferation, providing insights into its potential as a therapeutic target for cardiovascular diseases associated with dysregulated autophagy and cell growth.

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
GUAUCUGACUCAGGACCUGAUUUAAGGUUUGGGGUUUUUUGGCCCUUUGUUUCUUCCUCUUGUUUUUUGACCUUUAGUUACUCCACACCUCAUUAGUUCCUUGACCUGCAGGUGGACUGAGAAGAGAGCCAUGGUAGCAGGCAAGAGUGUGGUUAUCGUUGGACCAGGAUUCAGGAUCUGACUGAGUAGCUGACUCUUAAUCCAGUUUGUGUUGAUCACCAGGAGGAUCUGGACCUCAGUAUUACCACAUCUAGAGCUAUAAUCACAUCCCUGUUAAGCCUUCCUGAGAUCACACCAAAUGUCCUUGAUGGGAAUUGUAAACAACCCUUACUUCUGGUUUCUAAUGAUAUUCCAGGAAAGGAGCCUAACUAGAGUCAGUGAUAUGCCAACUCCACCUUUGCCUUCCACCAUGUUUGGAAGCUCCCUGAGGCCUCACCAGGAGCAGAUGCUCGUCCCAUGCUUCCUAUAAGCCUGCAGAACUGUGAGCCAUAAUAAACUGUGAAUUAUAAAUUGCCUUUAUAGCAAUGCAAAUGGACCAGUACAGAUGGGAUGCUGGGAAGACAGUUGUUUCCACCUUCAGUAAAGUCCGUGGAACACAGUUGUGACUAUAUUCUAGGCCAGCCAAGAUGCUUGUACUCAGAAAGGAGUGGUCUCAGGACCAUAAGAAAGUGAAAAAAUAAAAAUAAGAAAAUAAAGAAGGGAUUGUCAAUGAAUCAGAAUUCAUCAAGGUCAAAGUCUUAGGAAAUUCCUUCAUGAGGAAGUCUAGGGGGGCUAUGGAAAUGAAAUUUUUAAACAAAUAGGUAUGUGGUGCUGGCAGGAAUAAAUUAUGGACUUAUGAAUAUAACAUAAGAUUCUUUAUUACCUGGUCUCACCCGUCUUUCCACCUCUGCCCCCCUUCUUGCCCGACUCUGUGUAUCACCCAUAAUAAACUACUUACAGCUUCCUAGUGUUAAAUUUACCCUAAAAAAAAAAAAAAA

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications