v24

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Homo sapiens (human) long intergenic non-protein coding RNA 690 (LINC00690) URS000075D67C_9606

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LINC00690: LINC00690 is a long non-coding RNA (lncRNA) that has been found to be downregulated in the blood of individuals with Parkinson's disease with dementia (PDC) [PMC8683173]. It has been identified as a nearby targeted mRNA of upregulated RFTN1 [PMC8683173]. The downregulation of LINC00690 and the upregulation of RFTN1 have been shown to play a significant role in the metabolic disorders associated with PDC [PMC8683173]. However, further research is needed to fully understand the functions of LINC00690 and RFTN1 in PDC [PMC8683173]. To date, there have been only a few articles that have investigated the role of LINC00690 in PDC, highlighting the need for more studies on this topic [PMC8683173]. In addition to LINC00690, other genes such as CA3, ORAI3, PIP4K2A, RP11-317J10.2, and AC135048.13 have also shown significant downregulation in the blood of individuals with PDC compared to those with normal brain cognition (BC) [PMC8683173]. In conclusion, LINC00690 is a downregulated lncRNA in individuals with PDC and is associated with metabolic disorders. It is targeted by upregulated RFTN1 and further research is needed to fully understand its functions in PDC. The dysregulation of other genes such as CA3, ORAI3, PIP4K2A, RP11-317J10.2, and AC135048.13 also contributes to the pathogenesis of PDC [PMC8683173].

Genome locations

Gene Ontology annotations

Sequence

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CCGCCUUCCGGAUGGAUGAAAGCAGAAGCAGUGGCUGGAGCUAGAGCAGCUAUUUAGGACUAUGAGAUGGAAGAAAUGUGGUGACAAUAGCAGAACAAAAAUAUAGAAAUCUUGGGUACUUGAUGACCACGGAGCCGCCAUACAAACUCUGGACUAUAAUUUCCAGAGACUGUUUAUAGAAUGAAGAUACUGUCAUUACCUCUGCAAAGAAUGCAUCCUAGCACAGAUCAAAGAUCUUCCAAGUCCAGCCACACCAUUUUACAGUUCUGAACCUCGACUUAGGAAAGCAGUGGAUCUUUAUACAUUUGACACAUCCCUUCCCUCUAGGAUCUCUGUGGCUAUUGAAAAUGGACUGGAGAAGAUGAGUGGGAGUGAGAAGAGGAUAACAGAAUCAGAUAAAAACCUGUCAUGUUACUAAGAGCAGGAGAUGAGGCAGCCUGGACCAAGAUGGUGGCAGAGAGAAGAAAAUUGCUUGAGAGAAUUGAUUAAACUACUUGGUUAGCACAGAUAGAGCUGAAUCAAAAAUUAGGAUGGUAAGCUAAGUAAUUUUACACACAAAAAGGCAGAGUUGCAUUCAUAAUUAGUCUCUCCUUCAGACUGAAUAUUACAGACAAAAUAUAGCCAUUGGUGUUGCAAUCACUUCCUUUGGGUUUGUAUCCAAGGUUAAGAAUGUCAGCAUCCAAAGACCCAAAUUCUUAAUGUUUUUAGUUGAUAAAGUUUAUUCAAGGUAGACAGCCUGUGUUGAAUAACUUAGUCUUCCACAAAUUUCAAGAAAAAUCCAUUGUCCCUCUUCUCCGCCACAGACACACUUUAGUUGAACAUUAAGCAUAUUUAUUAAAGAAACAUUCUCCUUGUGCUUUUUCUCCCAAGAUGGAUGGUGUUCUUACUUAGAGUUAUAAGUGUCAGAAUAAAAAUGCCCAUGAGGUUGAAUUGUAUGAUGUUAUAGUAAAGUGAGAUAAACAUUCUCAGAAACAUGAUUGUGACUUAAAAAAAAAAAAAACCAACAAACCACUUUCUGUAGAGGAAUUAUGCUUUGGGGACAGAAACUUUCCUUUAUAAUUUUUACAGCUGCACGCAGAUAAAGUGUAUUAAAAAGGCACAACACAUCAAUUAUGAAAACAUGGCUACCCUUUAAGAGAACACAGACUUUUUCCAGAUCCAUCUUAAAUCUCAGGAAUUCUAGAUCGAGACAGGCAUGAAUGCUCCUGUUGCUGAAAUCACUCUGAUUUCCUUCUUGUUAAACACUUCACUCAGCAACAUUAUAGAUUAGCACCAAAAAAGUUGUUUGUAGGUGAAAAACUGUUCAGAAAAGGACACCUUAUUAGGCAGGCUGUCGAUUUACAAAUAAAAGCCGAUUCUGGCUCUCCAAAAAAAAAAAAAAAA

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Publications