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Homo sapiens (human) p53 upregulated regulator of p53 levels (PURPL) URS000075D3F5_9606

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PURPL: PURPL is a long non-coding RNA (lncRNA) that has been studied in various cancer types. The PURPL-wide type (WT) reporter vector and the PURPL-mutated type (MUT) reporter vector were constructed by inserting the PURPL sequence, including a possible or mutated miR-363 binding site, into the psiCHECK-2 plasmid [PMC8536668]. It has been found that PURPL regulates the infiltration of monocytes and CD8 T cells [PMC9154001]. Knocking down the expression of PURPL using specific antisense oligonucleotides (ASOs) revealed its involvement in autophagy-related features [PMC8581000]. In ovarian cancer tissues, there was a significantly upregulated expression profile of PURPL [PMC8364645]. The localization of PURPL in the cytoplasm suggests that its role in melanoma differs from its role in colorectal cancer [PMC8581000]. Overexpression of PURPL, along with miR-137 mimics or si-ZBTB7A, was found to affect PI3K/AKT/NF-κB expression in an AGS cell model [PMC8805877]. The curcumin analog DA 0324 was shown to lower the profile of PURPL and impede malignant gastric cancer progression [PMC8805877]. Additionally, basal loss of PURPL led to an increase in p53 signaling and transcriptional activity [PMC6567798]. It has been identified that lncRNA p53 upregulated regulator of p53 levels (PURPL) can target miR-338-3p according to biomedical database queries [PMC8364645].

Genome locations

Gene Ontology annotations

Sequence

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CUGGGAAUCAAUGUGUGAGGUGGUGCUAUGUAGCAGGAACCCCUCUUGCUUUGCAAAUAGUUUUUUGUUUGUUUUCCUUUUUGCCCAAUAGAGCCCUGCUCUACUGACCCUUCAAUGUGCCCGUGUGCCUAAAUAUUCCUGGUCGUGUGAAAAGAACCCAGGUAUUAGCUGAACUAAGGAGCACAAUUCUGCAACAUUUUGGCACCCAAACACGGGGCUUGAGAAAUGAAUGCAAUUGGAGAAACUGGUUGUUUUACCAGGCGUUGAUUGGAAAUGUGUGCUUCCCUUUAAGCAGUCAAGCUCAACUUGCAGAACUGAUGGGAACCCCUUGGGAAAACUGGCCUCAAAUGUUUGUCUACACAGUCCACAUACAGGGUUCUUAACCUGCGAUGAGGGAAACUUCCCAGGGCUUGUCUGGGUAUGCCCACAGUGGACUGGAGCCCAAAAUGCACACUGGAGGAAGUGGAUGGAGCCACGUGGAUGUCAUGCCUUAUGCAGGGGAGGAGCCUGCUCUCUUCAGCUCCUGUGGUAAUGUGGGAAUCGAUCUGUGAGCAUAUUUAACUAUCCGGCUAUUUUGGAGAUUGAAAAAAGAAGACCUGAUUUAUCAUGUGCAAUAUCUCACACAUCUGUCAUUUCUAUUCUACCGCAAUUCGAUGGAGUCUUGUUCUGUGGUCCAGGCUAGAGGGCAGUGGCAUGAUCUCGGCUCACUACAAGCUCUGCCUCCCGGGUUCACGCCAUUCUCCUGCCUCAGCCUCCUGAGUAGCUGGGACUACAGGCGCCCGCCACCACGCCUGGCUAAUUUUUUGUAUAUUUACUAGAGAUGGCUAGUGUUAGCCAAGAUGGUCUCGAUCUCCUGACCUCGUGAUCUGCCCACCUCAGCCUGCCAAAGUGCUGGGAUUACUGGCGUGAGCCACCGUGCCUGGCCAGCAUCCUCUAAUUAUUAUUCAUAGUUUGUGAAUUUAGGCCUACGUGAAUAAUAAUAUAAUAUUUACUAUGAUGUUACUAUCUACCAACCUUAUUUUUCUUUUCUAUAAAAUAGGAGCCAAAAUAAUAUUUAUGUCAUACCUUAUGAAGUUAAAAUAAAAUAUAACGAAUGAGGGGCUUAAAAAAAAAAAAAAAA

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Publications