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Homo sapiens (human) NALCN antisense RNA 1 (NALCN-AS1) URS000075D232_9606

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NALCN-AS1: NALCN-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various diseases, including bladder cancer, lung cancer, and psychiatric disorders such as schizophrenia and bipolar disorder [PMC8186793] [PMC9172899] [PMC7191674] [PMC4626154] [PMC9691318] [PMC10154523] [PMC6863898]. In bladder cancer, NALCN-AS1 is one of the DElncRNAs that has been found to be related to overall survival and prognosis [PMC8186793]. It is also part of a nine-lncRNA signature that can predict the overall survival and prognosis of bladder cancer patients [PMC9172899]. In lung cancer, NALCN-AS1 is associated with certain single nucleotide polymorphisms (SNPs) that have not been previously linked to the disease. These SNPs include rs10508047 and rs4445762 on the NALCN-AS1 gene, as well as rs6558165 on the CCAR2 gene and rs2284985 on the SIM2 gene. These SNPs have significant p-values and odds ratios in relation to lung cancer risk [PMC7191674]. Furthermore, NALCN-AS1 has been found to be differentially expressed in tumors with specific pathological stages in bladder cancer. It is dysregulated in tumors with pathologic M stage and pathologic N stage. Additionally, it is one of the lncRNAs associated with overall survival in bladder cancer patients according to univariate Cox regression analysis [PMC6614857]. Overall, NALCN-AS1 plays a role in various diseases and can serve as a potential biomarker for prognosis prediction.

Genome locations

Gene Ontology annotations

Sequence

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CUCGCAAGACCUGGUUGUUUAAAAGUGGGCGGCACCUUCCCCUUCGCUCUUCCUCCUGCUCCUGCCCUGAUGUGUCUGGAUGGUGACAGAUGGGAAUCUUCUCCAGUGACCAGAAUCCAUGCCUUACCUUGGGAGCCCAAGCUGACUUCUCAAGCUCUGGGGAUGCCUCAGUGAUCUCUGAUGUGGAAUUAGUGGAGGCUGGCCGUUGCUCACCUCUACACAGCCUGCUGGUCGUUAGCGAGCAGGAGUUCUGAUGUUCCUCUCAUCUUGGAUGUCUUUCCUAGGAGAAUAUUUCUCACGUGUUUGACAGAAAACAUUAUCUGUCCAUCAUUUCCAUGGAUUCCUGGGUCUCACGGGCAGAAGGACAAGGCAGAUAUGAGGCGGAUCUGGUAAAACCAUAAACACCAUGAGAUCAGAGCAUCCAUCUGUAGACUCACAGAGCAAGAAGCGUGACUGCCCCAAUCUUGAAUGGAUGAGUAAGAUGAAAAUCAAUUUAUAAACAUCUUGUGACAAGCUGGAAUUCAGUUAUAGAUCAAUUACAGAUUGCUCACUGGACAAUCAAGGACAUUAUUAGAAAACGGUUUCCACCACUAGAAAUUCAUCUACAUUGACAUCCACCUAAAUAUCCAGAAGGUCAUCCCCACUUUCGUCGCUCUCCACAGUCAGCUGCCGGGUCCACCACUUCUUAACUUCAGAACCGCAGGAAGCCGCGUCAGUCAUGGGGUUCAUUUUGCACACGACAGAUUUCAUGGUUGUCCUUCCUCCAAACCGAGGAACCUAGAUCUUCUCUGAUCUCUGAAAAAUAAGUUCCUGGAUAUGAAAGGGGAUACUUUCCUUGGUGGUAGUCCCAGUGAAGACCCACUGAACAUCGUCAGCCUCAAAAUGUAAGCUGUGCUGUCAUCUGCUUUGUGGAACACAUAUGCUACACAUCUUCUCCUUUCAAUUGGGCUGAAGUUGGGGCACAGUUAAAGAGCAUUAUAAAGCUCCUGCUUUAGCAUGAACUUAGUUAUCUAUAGAAAAAAACAUGUACAAGGACACUGGGCUGUGGGGAGCAUUGCUCUCCCUCCAUUCCUGAGUGCUCUUAAUGGGAUUAUCCUGGCUUUCCAAAACCCUAUAGAGAAGAAGCUCAUAGAAGAAAAUUCUCUUACUGAAUCAGUAAAAUAUGGAAAAUAAUGGGACUGUUUAUUAAAGGAUUGAAUGAGAGAACACAAGUAAUGCACUUAGAAGAGUGACUGGCAUACAGUGAGUACUACGUGCUGGCUUCUCAACCAUGAUAGCCUGAAAUGUACCCGGAAAAUGGGGGCUAAUGUAAGUCAUAUUUAGAGAAGUUAUUUUGGGGGACAAUGUUUUUGACAAGACUACAUUUUUCAUUAUGUUGCUGUCUGUAAACAACUGUAGAUGCAGACUUGCAUUUUGAAAGGCAAGACCCAAAACACACAAACAGAGUAAAUACCUUUAAAAUGCCUCGAUCGCUGGAGAAAUGCCUGGAUGGACCUACCUGAGGGCAGACGCCACUGCCCAAAUUUCCUCUGGGGUUUCCCUGCGUCGGCUGCAUCUUGCCGACUUCCUCCUCGAUCCGACAGCGUGGGGCUCAGGAGCUGCUGCUGGCUGCUUGUCUGCAUGGGAGGAGAAGCACACAGUUACCGUCUUUUUAACCCUGCGCUCUCCUCCUUUUACUAUAAGAAAGGAAAACACAUGGCAGGAGGACAAGUGGGAAGAACAACAUGGACUCAGAGUGUCCACAAUGGGGAAAAGUGAAAAUGGGUAUAAAGGGUCACAGAAGAAAAAGAGCCACCACUGCACGCCCUGCUGAAGGAGACACCACUCUUCCUGGGACAUCUUGUCCUGGGUAACCCCCACUGCUUCGUUCCCCUCCAUGCCUGAGAAUGUCAUUGUUUCCCUUCAUAUCUUCGCUGGCAAACCAGGGGGUAAGGAAGGGGAACUGCAGGAAGGAAGGUGGGGCAGUGGGGACGGGCUGGGCGGGGGCAGUCUACUGUCACCAGCCUGGAGAUCCACACUUAGAGCUUCAGGGAAAGAGUUCUCUGCAGGCAAAGCUGUAUGAUGGGCCCUGGUGGAGGAUGGAGCUGAUAACAAUCUAAGCUACAGUGAAAGAAAGAGAGAUGCCAAGACUUCCCACACAUUUCACCUGUUCUCAGGUUCACCUGUCACCUCUCCCUUUCCUAACAAAAGCCUUGGUCUUCACAUCUCUUUAGUAUCCUUUUUUUUUUUUUUUUGUCACCUCUUUCUUUCUUAGGCUUUUUCAUCUAAAAACAGAGGGCUCUGAAAUCAUCACUUUCCCCAACCUCAUUAGCCCUGUCUCACUGUCUGUCCUGACUUCAGCCUGCCUCCCUCUCCCAUGCGAGACAUUGCCAACCAUCUUCAGGGUGACCAGUGGCAAGGCCACUGCAGAUGCCUCCCCUUGCCCCUUGGUUGACUAACUCCGCAGAAGUCCCUGCAGUCGGUGGCAGAUGAUUUCUAAAGGCUGGGGAGCCCAAAACAUGAGAUCUACUGAAAACUGAGCUAUGGCACCAGUGGGCCUCCUGGAGCACCCUGCUGGGCCGUGGAGCCUUAGGCUUCCAAAGGUACUCUGGCCCCUGGCUGCGUUGCUGCACACCAUGGAGCCUGGUGCUGCUGGGGGCUCUGCACAGAGCACGGGAUCAGCUCCACGUUGUUAACCUCAAAUCGUAAUUGCUGCCUCAUAAAGGGGCAGGUCCUCCCAGCCAGCUGCUUCUCACAGCACAGGACUCUCCAGGACGCUGAUAACUCCUUGUACUUUUUUAUAUAGACACAUACAUAGAGUUUGAAAAUGAAAAUAUGCUGUGACUUAAUAAAUAGAAACUCCUCAAAAAAAAAAAAAAAAA

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Publications