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Homo sapiens (human) PCBP1 antisense RNA 1 (PCBP1-AS1) URS000075CE39_9606

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PCBP1-AS1: PCBP1-AS1 is a long non-coding RNA (lncRNA) that has been studied in relation to cervical cancer [1]. In a study by [1], cervical cancer samples were divided into two groups based on the median value of PCBP1-AS1 expression. The study found that higher expressions of PCBP1-AS1 were associated with poorer prognoses for sufferers of cervical cancer. Additionally, [2] found that PCBP1-AS1 may play a role in the deubiquitination of AR/AR-V7, a protein involved in the progression of prostate cancer. The lncRNA was found to stabilize the USP22-AR/AR-V7 complexes, preventing AR/AR-V7 degradation through the ubiquitin-proteasome pathway. Furthermore, upregulation of PCBP1-AS1 was shown to significantly increase NF-κB activity, while downregulation of TRAF5 (a protein involved in NF-κB signaling) decreased NF-κB activity [3]. These findings suggest that PCBP1-AS1 may have an impact on both prostate and cervical cancer progression through its interactions with AR/AR-V7 and NF-κB signaling pathways. Further research is needed to fully understand the mechanisms by which PCBP1-AS1 influences these processes and its potential as a therapeutic target for these types of cancers. References: [1] PMC8023048 [2] PMC9115606 [3] PMC8798148

Genome locations

Gene Ontology annotations

Sequence

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CGGGGGGGAGGGGCGGCGAGGCGAGGCCUGCGGAGCGGAGGAAGACAAACAUAAAGAUGAAGUGCUUAAUUCAAGGUCACACAAUGUCGGGGAUGGACCUCCAGAUUUCCUUACUGACCUGCAUUAUCUUGUGGAUACCUGAGUGAAUUCCACACCACCCAUUUUAUAGAUGAAACCACUGAGACAUGGAGCAAUUGACUGAGUAGUCACUGCCCCACCCCUGCCUGGAGCCUCACACAUGACUCGCCUCCUCUCAGUGACCACAGAUGGAGUCUUGCUGUGUCACCAGGAUGGAGUGCAGUGGCGCAAUCUCGGCUCACUGCAACCUCUGCUUCCCGGGUUCAAGUGAUUCUCCUGCCUCAGCAACCCGAGUAGCUGGCACUACAGGAAAACAAGCUCAGGGCUCCCACUGAUUGUACAUUAUGGUGAGACGUGGUCUUGUAACACAGUGGUUAAGAAUGUGACUUUGGAGCCAGCCUGCUAGGGGCUGAAUUCUGACUCAGCCAUUUACUAACUGUGUGACCUUAGGGAGGAGGACCUGGUUGAUAGAAGAAUUUAUCUCGUAGUCUUAACAUCCACUGUAAUUCCAAACUUUGAGGACGAUAGAGAUCAGUGGGCUUUGACUGCCCAGCAUGCAGUCUCCAUUCUUAGGUCACAGAAUUUUCCACACUCCUUGACAGAGGUGCUUAACCCUUAUCCAUCAGCAUUCUCAGACAGCACCUCCGGUUAGGGACAGUAUCUGACCGUCCGACAUCCCUGCAGCCCCCAUGUGUCACACAGACUCAGCCUCAGGUAGAUGGUUUCCGUAGAUGGUGGCUUUCUUUGGACCCUUGACAUCAACCAGUUACUAUUUGACUCUUCUGCAGAACCCCAUGUUGACCCCUGCUUUGAGGUGGCAGAGUUAACACUACUCUUCGUUAUAAGCUCUCGUCUGGGGCAACUCAGAAGAACCCAGAGACAGACUCCCAGACUCGGCCAGAGGCUGAUGCCAACUCCUUCCAGCUCUCACGGUAACCAUGAGGCCCCUGCGUGUUUCUGUUGUGGAGGUCCCAGAGGGAACUGUAUGGACAGACACAGCCCGAAGGGCCAUCUGCCUCAAGCCACAGCAGCACAGAAUUCUAAAGAUUGUGGGGAAGGAUGGGGCCAAGGGGACCAGAUGUGCAGAGGUAAUGAAUACCAGGGAAUCAGGAAACCACUGGAUCAGUUCUUUGAGCCACAGAACAACACUCAUCCCAGCAGCUGGGAAGCUAUCUGCAAAAGUCCAUCUGCAGAAAGGGCUUCCUGGUCUUGCGUGUGGCUGGGCCAUUUCUCUGGAUGCAGGUUUUUCAUUAUACAGUCUUCUCAAAGAACCACCUGCUCUCAACACCUUCUCGGUGACUCCAUUUCCCCUCCUCUGGGCUCCUGGAAUGCCACAAUGGCCCCACCUUAGCCAGGCAGCUGUGAUGAGAGGUGUUGACCCAACUGCCUCUCUGCUGGCUCACUGAAUCAGGUGGAAGGGGCUGGGGACAGCACAGUCUUGCAUUGUGGUUGGGGACCUGGGCCAUCCAGAGGCAGGACUGUCCAAAGGCAGGGUACUGCUGGGAUUCCGCCAGGCACUGGGUGAUGCAUGGCAUAGGGAGCUGAAGAGGGACAGGCUCUUGGCCAGGAAAAACAGCCCCAGAGCCACAGGUGUGCCAUCGAGUCUUCCUCCUCUCCCAUCCUUAAUCACUCCUGUUUGGUGACAGCACACAGCUAGGCCUGGAGCCCAGCAAAGAGCCCCUGGGUCCCAGAGGAAGUUGUUCUGGGGGCUGGAGACAAUCACAAAUGCCAGGUUUGUGAGCCCCAGACUCUGGUUCAUAGCAAGAGGCAGACUUGUGAACAAACCACCAGAUCACACCGUAAAACACGCUCAACGAGGAGUGGGUGCCCUUUCUAGGGACAGGCAGAAGGCUCCAUGGAGUGACCUUUGAAUGGGGACAUAAAAGUGGAUCCCUUCAACAGCCCCUGCACAGCCCCAAGUCAGGCCUCCAGCCCUUGGACUCACAGAUGUCCUCUGUAGACGACUGGAUGUCCUCCCGUGCUACCCUUUACCCCUGCAGCGAGGGGCACAGAGCCAGAGCCCUCCAGGUCCUCACCACUGGCAUCACCAACAUAGUGGACAUUUUCCCUCUCAGAAUGAAAAGGGAGUGAAAUUUCCCGUGAUCUUUCCACAAAUGACCAGCUUGGGGAGUGGGAGAGGAAGUGCUGCAGUGCCUGGGGAAGGGGCCCUGGAACAGUUCCUGGAAAUGGAGAGGGGUGGAUAGGGUGGAGACAAUGCUCAUGGAGUGCAGUAUGGGGCCUACCCAGAGUUGCUUGGCCACCCCUCUGCCUCUGAAUCAGGGGUGAUCAAUGAAGGAAAAUUACUGCAAAAAAAAAAA

Taxonomic tree

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Publications