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Homo sapiens (human) long intergenic non-protein coding RNA 1140 (LINC01140) URS000075CD48_9606

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LINC01140: LINC01140 is a long non-coding RNA (lncRNA) that has been studied in various types of cancer. It has been reported to act as a tumor suppressor in breast cancer by downregulating its expression and affecting the epithelial-mesenchymal transition (EMT) process of cells through the adsorption of miR-200b and miR-200c [PMC8395365]. In glioma cells, LINC01140 has been found to inhibit the malignant phenotype by modulating the miR-199a-3p/ZHX1 signaling pathway [PMC6465406]. LINC01140 shares miRNA families, such as miR-200c and miR-200b, with PITX2 [PMC6955654]. In bladder cancer cells, knockdown of LINC01140 significantly inhibited cell viability, migration, and invasiveness [PMC7803526]. It has also been shown that LINC01140 is upregulated in breast cancer cell lines [PMC9592237]. However, there is no study showing a connection between LINC01140 and lung adenocarcinoma (LUAD) [PMC8004399]. In thyroid-associated ophthalmopathy (TAO), LINC01140 was identified as one of the differentially expressed lncRNAs in orbital tissue [PMC10067720]. Furthermore, LINC01140 directly inhibits the expression levels of miR-377-3p and miR-155-5p, leading to upregulation of their common downstream target PD-L1 [PMC9942365]. Additionally, higher levels of LINC01140 have been associated with decreased survival in gastric carcinoma patients [PMC7803526].

Genome locations

Gene Ontology annotations

Sequence

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GGAACAUCCUCGCGGCCCGAGGCGCGGUCGCAGCCGGGGAGCACUCGCCACGGUGCUGUGGAAUUCUCUGGUUUUUCACGCAAGGUCAGGCGUCCUGCUGGCGCCCUCUCGCCACCCUGCCCUCCCGUCAGAAGCCCGGCUCCUCGCCGGGGAAGGCCGGAUGCUGGCCCGCCGGGACCUGGGACUUGUGCCACAUGGAGUGUCGGGAGUCUCCAUUGCCGCGAGUUCUACACCACAGGGCCAGGCUGUUUGCUCCCCAUCGGUCGCUGCCCCCAGCACCCUGUUGUUAUUAAGGACUCAUUUGCUUGGAGCGGCAUCAUUACAAGGGUGUGGGGUCGCGGCUCCUUUGUCCAGGACUACGCAGGGGCUUGACCCCAGGGCGCUGGUUUAGGCCGGAUCUGGGGUCCCUUGUCACUCCCAGGCUUCUUCCACUUCCGAAUUCUGGAGAACCGGGAAUCAAGCCCUGCGCGUUCCUCUUCUUCCUCCUUCGUGCCGAAAGCACGCUUCAUGUCUGCCAGGGCAUCAGUUCUGAAACACCAGAUACUGCUACACCAUCUCAUCGGCAUGGACCUAUAUGUGGCAGCAAGUCCAUCUCAUCGCUUUUGGUGAAAGUCAGUCCAGUUUGUAAAGAUUCUCAUUGUCACUGUAGACGAGGAACUGGGACACCAAAAGGAGAAACUCUGGCCACGCUUGCACCCUGUUCCCAAUCCUGGUCCAGUGUCACCCACAGAUGGUAAGGAGCUCUAGAGACCUCACCAGCCCCUGGGAUUGGUCACCUCACUCUUCUAUGGACAGAGAUUCCUGCUGGGAUCCUUUGAGGGCAAGCAGACCCUUCUUCCAGCUCGGACUGUGAACUCCACUGCAGCCGUAAGGACUGUCUGUGACAGUGAGCCCGAGAUGACUGGGCUCUGUGCUCCCUCCCGGCCCUCCAAUCCUUGGCCUGCCACAGAGAACUGAGCUCUUUUAUUAGCACCAUGAAUGUGACUGAUACAGCUAGCCAUUCCCUUGUGCGAAUGACUCAGUUUAUUAAUGCUCUGCUAAAGAUGGCUUCUUUGCUUGCCAGCAGCCUUAAACAGUAUUUCAUUAAAACUGGCUUAAUUAUUUUGAGAAGACGGCCCAAUUAAAAGCUAUACACUCCCUCUAUGUGAGUGUUUAUACAUAGAGCUGUAUAUAUAAUACAUAUUUGUAAGUGUGUAUAUAUAUAUGUGUGUAUGUAUGUGUCUAUAAAUAUAUAGGCUUAGCAAUUUCAUUACAUGGGAUAAAUUGUUGGAAAAAAUACCCAGGAGCUGGUCCCCUUUCUGUUGCUAGAUUCAGAGUAGAGGCCACCCCUCCACUCUGGGAGAGGCUGGUGUUGGUGAUCUCUCAAUGACUCUGCAAUGGAAGUCCCAACUGCACAGAGCCCUGCCCCAGUUUCAGGAGCCAGCAGCCUCGGAGAGGCGGAUCCUGACCUCUGCUCUGCUCUUGGGAUAGCCUUUCCCUUCCCAGCAGGGUUGAGAUACUUGGGCCGGGAAAUGUUGUGGCAAAGUGUUUGCCAAAGCUCAGGAGAGACACAGACUUGGGGCUUUUGUUUCUUGAGCUGGCUGUCUAGCUUUCCUAAUGAGCAAAUAUGUUCUCUUUAAGGAAACAAACAAACAAAGCAAAAACACCAAUUCAUCUGGAUUUUAUUCAUUUGUUUUAAAUACAAACAAACAAAAGGAGAGUGGUUAUUUCUGCACCAACUAUUUCAAAUGCAAGUUACUCCAUCGCUCGGGGUGGUUGGAUGGUGCUUGUCACCAUAGGACCCACAGGGCUAGUUCCAACUGUUAUUCGGUAAGGCUUUUUUCUUUCCAAAAUUCCCAGUGUUCCUUUAAGGCCCAUUUAGCUGCGGGUUUUGUUUAUUCUCCCGGCAAUCAGCAUUUAAAAUAAGACAAACAAGCAUUUUUUCCUGGGCUGUGAAUCCCCCCGGCCAGCCUCCACCUGCACACCUGAAGCCAGCAUGUCCAAUCAAAUUUCUCUGUAACCCAUAUCCCCUUUAGAGACUUGCCCCCGUCGUAUACCAGGCUGGAAAUAGAGAACUUAAGCAGGGCAAAUGUAAUUUUAAGAAUUGCUAAUGAUGCUAGAAAUCUGCAAUGCAAUUAGCGUCAUUGGAUUUGGCGCUCCUCCGAAGGCACAAAACUCCUUGUCAUAGCGCAGUGGCAGCAGCGGCAAGUGCCUCCGCAUGUGCCGGGCUGUCCGGGUAUGCUGGCAGCCGCUUUGCACUGAGAUGUGAGCAGUUGGUUAGGCUUCCUCUCUUUCUUUCUCACAGAUACUGACUUCUUUGUCUCUUUUCUGGGUUGCAGAGGGAUGGGUAUUUUCCAUUGAUUAUUACUUUAGCAUUUGACCCUCCAGUGGAGUCACCCUGUUUUUUUUUUAGAAAACUGAGACUCUCACUUUGUGAAUUCACUGUGCUCUCUGGGAUUUCAGUGCUGUAGUUCAACCACCAAUCCCCCUGUCCUGAACUCCAGUACUUCUGAUGCUAUUAAUUGGUUCCUCAACAAUUGUGGCCUUUUCCAUCAUUGCCCACCAUAGUAUAUACUUUUUCUUUCUCUCUCUUUUUUCUAAUUUCCUUGUCUUCUUCACUCUCCAUGGAGCCAGAGGUAGUAUGAAGAGUUAAAAAUAGGAAUAUAAAGAAAGCCAGAGGGACAGAGGGAGUGAGAAAGAAAAAUUUUAAAAAGGGAGGAAAUGAAUUAUUGGAUUAAAAAUAAACUUUUACUUUUUUGCAGAAAAAUUAUUUUUGCUCUCUGGGAAAAUAACAUGGGCCAGGCAUAAAAAGCAUGUCAGCUGGCUAAAAGAUUGCAAAAUCCAGAAGAUGAUCUCGAUGUGUCUGUUCAAUUUAGCAAGGGUAUCUACUAGGGGAUCCUCUUUUAAAUAUGGAGGCCCAAAUCAGAAGCUUGUAGAGGGGAGCUAUUCUUCCAAGAUUCCAGAUGUGUCUGUGAGACAACACGUUAUGGGGCAAAUUGAUUUCACCCUUGGGAAACCAGGGAGAUUUUCAAAGUUAUGUCUGCAAAGCCAGCUAAUGCAAUUCCCCAUUAGUGCAUUAAAGUGCGCCCUUAUUAAUUCAAACAUAAAGGCAACAAAAUAAGCUUUUAAAUUUAAAAUAUAAUACAUAUAUAAUGAGCAUGUGUGAAAGCCUUAUUCAAAUGAAAAUACAGGAGUGUUUGAACUACUGAGGUAUCUUUUGUAUUGAAUUAUGAGCAUAUGUAAUAGAUUUAAUUAUUAAUUUCCCCAUUGUUCUAUGCACACAGACAGGGUUCAAGGCACAGUCAUUCUCUGGCUUUCAUAGAUCUAAUUUGUAUAAUUAUUGCCUGAAUAAAAAAUUGCUCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications