v24

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Homo sapiens (human) HAGLR opposite strand lncRNA (HAGLROS) URS000075CA0B_9606

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HAGLROS: HAGLROS is a long non-coding RNA (lncRNA) that is up-regulated in gastric cancer (GC) due to STAT3 activation during tumor progression [PMC5767073]. Overexpression of HAGLROS promotes breast cancer (BC) growth, while knockdown of HAGLROS inhibits BC development [PMC9159766]. HAGLROS is highly expressed in various tumors, including BC, lung squamous cell carcinoma, and cervical squamous cell carcinoma [PMC9159766]. However, HAGLROS is not associated with hepatocellular carcinoma-specific survival [PMC9208501]. In non-small cell lung cancer (NSCLC), high expression of HAGLROS is associated with certain clinicopathological characteristics [PMC9068548]. HAGLROS can regulate apoptosis and autophagy in WI-38 cells through the miR-100/NF-κB axis [PMC9068548]. The siRNA sequence for HAGLROS knockdown is not provided in the given context [PMC7499284]. In various cancers, other lncRNAs have been found to play important roles in tumor progression and regulation of gene expression [PMC6558462]. In BC, it is hypothesized that HAGLROS regulates growth and metastasis through a ceRNA-dependent mechanism [PMC9159766]. Additionally, HAGLROS can bind with mTORC1 components to activate the mTOR pathway in gastric cancer cells [PMC8247385]. Furthermore, it has been suggested that HAGLROS inhibits autophagy by activating mTORC1 signals at least partially [PMC5767073]. The effects of HAGLROS on nephroblastoma are being studied through cell apoptosis detection methods [PMC9208483].

Genome locations

Gene Ontology annotations

Sequence

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GCUCUCCGCGCCUCAGCGAGCGGCCAGGCUGCGGGCGGGGUGGGCUGGCGCUCCUGAUCCACCUGGAACACUUUUGCAAAGACAGACGCGGUUCCUCCUACUUCAGAGCAAGUCUGGGCCAGCUGGGAUCCGACCAGAAAUCGCAAGCGGAGGAGACGCAGUAGCGCAGGCUGAGCGCUAACUGAAGGCGCGACCUGAGCCCGGCGCCUGCUGGGGAGCUGCGCAGCCAGGACAGCGGUCGGCAGCACAGGGCCUGGGCGCAGGGCCCGCCGUCACCACCUCACGUCGGAAGCCAGCACUGCUGCCCGCCAGCCCUGCCGCCUGCCCUCGGACUUCCCAGGGCGCCCAGGGUCCUCCCAACGCGCCUGCACCCACACCCGCCCCUGAGCCACAGUGACCUUGCAUUCCCCGCCCCCUGCCACACCUCCUGCGUGCCCGAGUGUCACCCUUAAAUACCGCUCUACACCCAGAGAGGGACGAAUACACCUCUGAAGACAGGGCAAGACUAAUUUCAAUGGGUCAGAAGGUUCUUGCAGGCACUGUUUUAUUUAAGAGUGCCUAUUUACUGGCAGGAGUAUUUGUGUGGGAGGAAGUAGGCUAAGACUGCUGUUGAACUUGAAGCUAAACUUGAAUGCCAUUUAAAAUAACAAUAAAAAUAUACUUAAAACACCAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications